Reviewed, UniProtKB/Swiss-Prot Q9PKT7 (TRXB_CHLMU)

Names and origin

Protein names

Recommended name:
    Thioredoxin reductase
      Short name=TRXR
    EC=1.8.1.9

Gene names

Name:	trxB
Ordered Locus Names:	TC_0375

Organism

Chlamydia muridarum [Complete proteome] [HAMAP]

Taxonomic identifier

83560 [NCBI]

Taxonomic lineage

Bacteria › Chlamydiae › Chlamydiales › Chlamydiaceae › Chlamydia

Protein attributes

Sequence length	312 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Thioredoxin + NADP+ = thioredoxin disulfide + NADPH.
Cofactor	Binds 1 FAD per subunit By similarity.
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm By similarity.
Miscellaneous	The active site is a redox-active disulfide bond.
Sequence similarities	Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Domain	Redox-active center
Ligand	FAD Flavoprotein NADP
Molecular function	Oxidoreductase
PTM	Disulfide bond
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW removal of superoxide radicals Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	FAD binding Inferred from electronic annotation. Source: InterPro electron carrier activity Inferred from electronic annotation. Source: InterPro thioredoxin-disulfide reductase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 312	312	Thioredoxin reductase		PRO_0000166724
Regions
	Nucleotide binding	33 – 43	11	FAD By similarity
	Nucleotide binding	283 – 292	10	FAD By similarity
Amino acid modifications
	Disulfide bond	138 ↔ 141		Redox-active By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9PKT7-1 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: 53824B207C24158D	FASTA	312	33,556
	10 20 30 40 50 60 MTHVKLAIIG SGPAGYTAAI YASRALLTPI LFEGFFSGIA GGQLMTTTEV ENFPGFPQGV 70 80 90 100 110 120 LGHQLMENMK MQAQRFGTQV IAKDITSVDF SVRPFVLKSG EDTFTCDACI IATGASAKRL 130 140 150 160 170 180 SIPGAGDNEF WQKGVTACAV CDGASPIFRD RDLFVIGGGD SALEEAMFLT RYGKRVFVVH 190 200 210 220 230 240 RRDTLRASKA MVNKAQANEK IVFLWNSEVV KILGDSLVRS IDIFNNVEKT TVTMEAAGVF 250 260 270 280 290 300 FAIGHQPNTA FLGGQLSLDE NGYIITEKGS SRTSVPGVFA AGDVQDKYYR QAITSAGSGC 310 MAALDAERFL EK

References

[1]

"Genome sequences of Chlamydia trachomatis MoPn and Chlamydia pneumoniae AR39." Read T.D., Brunham R.C., Shen C., Gill S.R., Heidelberg J.F., White O., Hickey E.K., Peterson J.D., Utterback T.R., Berry K.J., Bass S., Linher K.D., Weidman J.F., Khouri H.M., Craven B., Bowman C., Dodson R.J., Gwinn M.L. , Nelson W.C., DeBoy R.T., Kolonay J.F., McClarty G., Salzberg S.L., Eisen J.A., Fraser C.M. Nucleic Acids Res. 28:1397-1406(2000) [PubMed: 10684935] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MoPn / Nigg.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE002160 Genomic DNA. Translation: AAF39233.1.
PIR	C81710.
RefSeq	NP_296753.1.
3D structure databases
HSSP	HSSP built from PDB template 1VDC based on UniProtKB Q39243.
ModBase	Search...
Genome annotation databases
GeneID	1245727.
GenomeReviews	Gene locus TC_0375 in contig AE002160_GR.
KEGG	cmu:TC0375.
TIGR	TC_0375.
Phylogenomic databases
HOGENOM	Q9PKT7.
OMA	Q9PKT7. PSCGPCH.
Enzyme and pathway databases
BioCyc	CMUR243161:TC_0375-MON.
BRENDA	1.8.1.9. 256349.
Family and domain databases
InterPro	IPR013027. FAD_pyr_nucl-diS_OxRdtase. IPR008255. Pyr_nucl-diS_OxRdtase_2_AS. IPR001327. Pyr_OxRdtase_NAD_bd. IPR000103. Pyridine_nuc-diS_OxRdtase_2. IPR005982. Thioredox_Rdtase. [Graphical view]
Pfam	PF00070. Pyr_redox. 1 hit. PF07992. Pyr_redox_2. 1 hit. [Graphical view]
PRINTS	PR00368. FADPNR. PR00469. PNDRDTASEII.
ProDom	PD000139. FAD_pyr_redox. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR01292. TRX_reduct. 1 hit.
PROSITE	PS00573. PYRIDINE_REDOX_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TRXB_CHLMU

Accession

Primary (citable) accession number: Q9PKT7

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 2001
Last sequence update:	October 1, 2000
Last modified:	June 16, 2009
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)