Q9PKP3 (PKN1_CHLMU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Serine/threonine-protein kinase pkn1
EC=2.7.11.1

Gene names

Name:	pkn1
Ordered Locus Names:	TC_0422

Organism

Chlamydia muridarum (strain MoPn / Nigg) [Complete proteome] [HAMAP]

Taxonomic identifier

243161 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Chlamydiae/Verrucomicrobia group › Chlamydiae › Chlamydiia › Chlamydiales › Chlamydiaceae › Chlamydia/Chlamydophila group › Chlamydia › Chlamydia muridarum

Protein attributes

Sequence length	614 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Together with the serine/threonine kinase PknD, may play a role in the specific interactions with host proteins during intracellular growth.
Catalytic activity	ATP + a protein = ADP + a phosphoprotein.
Post-translational modification	Autophosphorylated on serine and threonine residues By similarity.
Sequence similarities	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Contains 1 protein kinase domain.
Caution	Gln-136 is present instead of the conserved Asp which is expected to be an active site residue.

Ontologies

Keywords
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW protein serine/threonine kinase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 614	614	Serine/threonine-protein kinase pkn1		PRO_0000171187
Regions
	Domain	13 – 302	290	Protein kinase
	Nucleotide binding	19 – 27	9	ATP By similarity
Sites
	Binding site	42	1	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9PKP3 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: A24D888E70258B75	FASTA	614	69,782
	10 20 30 40 50 60 MEEQSTVEYW GDYKVIAELE QGLWSRDVLT EHRFIKKRYV LKILPSELSL SEDFMKVFQK 70 80 90 100 110 120 VIVQLATIRH PSLVAIENVS QEKDRYFIVT EENSGTISLA KYLSGRKLSE EEIVYLIQQL 130 140 150 160 170 180 CEVLELVHEI GLAHGQINLH SVHVSFINGV ANIYLPEVGF ASLLRERMFS SIMQKASMQE 190 200 210 220 230 240 SVECIRDLLV FEAPEEKSTN HRATDAYSVG VLAYYLLVGA FPWGAFPKPS SCIPDSIYDW 250 260 270 280 290 300 DSFILSCLQQ QQQARPKRLR DALKKKTLGE QLQSTIDHCR ESLRAMEVQE EVSEPIAPTS 310 320 330 340 350 360 LIREGEKLFE GKEEQQAFVL VEAKSIDEAM VTTVDSEEVS ESGEGYVNPL QSLLAREPVV 370 380 390 400 410 420 SRYVEIEREE VKPQPLSTEM VFIEGGDFSR GSRDGQRDEL PVHNITLPGF LLDIHPVTNE 430 440 450 460 470 480 HFVRFLEFIG GEQDEHYNEL IRLKDSRIQR RSGRLIIEPG YAKHPVVGVT WYGASSYASW 490 500 510 520 530 540 IGKRLPSEAE WEVAAAGGKL GMRYPTGEDV DKSKANFFSS DTTPVMSYPA NILGLYDMAG 550 560 570 580 590 600 NIYEWCQDWY SYDFYENSAL EPDSPQGPPQ GVYRVLRGGC WKSLKEDLRC AHRHRNNPGA 610 INSTYGFRCA KDVK

References

[1]

"Genome sequences of Chlamydia trachomatis MoPn and Chlamydia pneumoniae AR39." Read T.D., Brunham R.C., Shen C., Gill S.R., Heidelberg J.F., White O., Hickey E.K., Peterson J.D., Utterback T.R., Berry K.J., Bass S., Linher K.D., Weidman J.F., Khouri H.M., Craven B., Bowman C., Dodson R.J., Gwinn M.L. , Nelson W.C., DeBoy R.T., Kolonay J.F., McClarty G., Salzberg S.L., Eisen J.A., Fraser C.M. Nucleic Acids Res. 28:1397-1406(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MoPn / Nigg.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE002160 Genomic DNA. Translation: AAF39278.1.
PIR	H81703.
RefSeq	NP_296799.1. NC_002620.2.
3D structure databases
ProteinModelPortal	Q9PKP3.
ModBase	Search...
Protein-protein interaction databases
STRING	243161.TC0422.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAF39278; AAF39278; TC_0422.
GeneID	1245775.
KEGG	cmu:TC0422.
PATRIC	20372250. VBIChlMur19118_0447.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0515.
OMA	EGYVNPL.
ProtClustDB	CLSK871217.
Enzyme and pathway databases
BioCyc	CMUR243161:GHYU-415-MONOMER.
Family and domain databases
Gene3D	3.90.1580.10. 1 hit.
InterPro	IPR016187. C-type_lectin_fold. IPR005532. FGE_dom. IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. [Graphical view]
Pfam	PF03781. FGE-sulfatase. 1 hit. PF00069. Pkinase. 1 hit. [Graphical view]
SUPFAM	SSF56436. C-type_lectin_fold. 1 hit. SSF56112. Kinase_like. 1 hit.
PROSITE	PS50011. PROTEIN_KINASE_DOM. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PKN1_CHLMU

Accession

Primary (citable) accession number: Q9PKP3

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 9, 2004
Last sequence update:	October 1, 2000
Last modified:	May 1, 2013
This is version 69 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program