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Protein

Glucose-6-phosphate 1-dehydrogenase

Gene

zwf

Organism
Chlamydia muridarum (strain MoPn / Nigg)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.UniRule annotation

Catalytic activityi

D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei57 – 571NADPUniRule annotation
Binding sitei168 – 1681NADPUniRule annotation
Binding sitei198 – 1981SubstrateUniRule annotation
Binding sitei202 – 2021SubstrateUniRule annotation
Binding sitei236 – 2361SubstrateUniRule annotation
Binding sitei255 – 2551SubstrateUniRule annotation
Active sitei260 – 2601Proton acceptorUniRule annotation
Binding sitei356 – 3561SubstrateUniRule annotation

GO - Molecular functioni

  1. glucose-6-phosphate dehydrogenase activity Source: UniProtKB-HAMAP
  2. NADP binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. pentose-phosphate shunt Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Carbohydrate metabolism, Glucose metabolism

Keywords - Ligandi

NADP

Enzyme and pathway databases

BioCyciCMUR243161:GHYU-474-MONOMER.
UniPathwayiUPA00115; UER00408.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate 1-dehydrogenaseUniRule annotation (EC:1.1.1.49UniRule annotation)
Short name:
G6PDUniRule annotation
Gene namesi
Name:zwfUniRule annotation
Ordered Locus Names:TC_0457
OrganismiChlamydia muridarum (strain MoPn / Nigg)
Taxonomic identifieri243161 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
ProteomesiUP000000800: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 507507Glucose-6-phosphate 1-dehydrogenasePRO_0000068115Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi243161.TC0457.

Structurei

3D structure databases

ProteinModelPortaliQ9PKK8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glucose-6-phosphate dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0364.
KOiK00036.
OMAiTIFEPIW.
OrthoDBiEOG61308Z.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_00966. G6PD.
InterProiIPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR23429. PTHR23429. 1 hit.
PfamiPF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000110. G6PD. 1 hit.
PRINTSiPR00079. G6PDHDRGNASE.
TIGRFAMsiTIGR00871. zwf. 1 hit.
PROSITEiPS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9PKK8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEEIKEMGPT LPACPPCVMV IFGATGDLTA RKLFPALYNL TKEGRLSENF
60 70 80 90 100
VCVGFARRPK SHEQFREEMR QAIQNFSHSS EIDIRVWESL EHRIFYHQAN
110 120 130 140 150
FSEAEGYSSL RSFLESVDQK YGTKGNRLFY LSTPPDYFQE IIRNLNRHQL
160 170 180 190 200
FYHEQGAQQP WSRLIIEKPF GVDLQTAQEL QQCIDANINE ESVYRIDHYL
210 220 230 240 250
GKETVQNILT IRFANTLFES CWNSQYIDHV QISVSESIGI GSRGNFFEKS
260 270 280 290 300
GMLRDMVQNH LMQLLCLLTM EPPSEFSSAE IKKEKIKILK KILPIREEDV
310 320 330 340 350
IRGQYGEGVV QGVSVSGYRE EENVDPNSLV ETYVALKLFI DNPRWKGVPF
360 370 380 390 400
YLQAGKRLPK RTTDIAVIFK KSSYDLFNSE NCPLCPLEND LLIIRIQPDE
410 420 430 440 450
GVALQFNCKV PGTNKLVRPV KMDFRYDSYF NTVTPEAYER LLCDCILGDR
460 470 480 490 500
TLFTSNEEVL ASWELFSPLL EQWSKIRPIF PNYIAGSLRP QGADELLSRD

GRAWRSY
Length:507
Mass (Da):58,548
Last modified:October 1, 2000 - v1
Checksum:iC66F3FE1562391A6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE002160 Genomic DNA. Translation: AAF73556.1.
RefSeqiNP_296834.1. NC_002620.2.
WP_010230499.1. NZ_ACOV01000003.1.

Genome annotation databases

EnsemblBacteriaiAAF73556; AAF73556; TC_0457.
GeneIDi1245812.
KEGGicmu:TC_0457.
PATRICi20372332. VBIChlMur19118_0486.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE002160 Genomic DNA. Translation: AAF73556.1.
RefSeqiNP_296834.1. NC_002620.2.
WP_010230499.1. NZ_ACOV01000003.1.

3D structure databases

ProteinModelPortaliQ9PKK8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243161.TC0457.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAF73556; AAF73556; TC_0457.
GeneIDi1245812.
KEGGicmu:TC_0457.
PATRICi20372332. VBIChlMur19118_0486.

Phylogenomic databases

eggNOGiCOG0364.
KOiK00036.
OMAiTIFEPIW.
OrthoDBiEOG61308Z.

Enzyme and pathway databases

UniPathwayiUPA00115; UER00408.
BioCyciCMUR243161:GHYU-474-MONOMER.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_00966. G6PD.
InterProiIPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR23429. PTHR23429. 1 hit.
PfamiPF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000110. G6PD. 1 hit.
PRINTSiPR00079. G6PDHDRGNASE.
TIGRFAMsiTIGR00871. zwf. 1 hit.
PROSITEiPS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MoPn / Nigg.

Entry informationi

Entry nameiG6PD_CHLMU
AccessioniPrimary (citable) accession number: Q9PKK8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: October 1, 2000
Last modified: February 4, 2015
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.