Reviewed, UniProtKB/Swiss-Prot Q9PKK8 (G6PD_CHLMU)

Names and origin

Protein names

Recommended name:
    Glucose-6-phosphate 1-dehydrogenase
      Short name=G6PD
    EC=1.1.1.49

Gene names

Name:	zwf
Ordered Locus Names:	TC_0457

Organism

Chlamydia muridarum [Complete proteome] [HAMAP]

Taxonomic identifier

83560 [NCBI]

Taxonomic lineage

Bacteria › Chlamydiae › Chlamydiales › Chlamydiaceae › Chlamydia

Protein attributes

Sequence length	507 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	D-glucose 6-phosphate + NADP(+) = D-glucono-1,5-lactone 6-phosphate + NADPH.
Pathway	Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3.
Sequence similarities	Belongs to the glucose-6-phosphate dehydrogenase family.

Ontologies

Keywords
Biological process	Carbohydrate metabolism Glucose metabolism
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 507	507	Glucose-6-phosphate 1-dehydrogenase		PRO_0000068115
Sites
	Active site	260	1	Proton acceptor By similarity
	Binding site	25	1	NADP By similarity
	Binding site	57	1	NADP By similarity
	Binding site	198	1	Substrate By similarity
	Binding site	202	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9PKK8-1 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: C66F3FE1562391A6	FASTA	507	58,548
	10 20 30 40 50 60 MEEIKEMGPT LPACPPCVMV IFGATGDLTA RKLFPALYNL TKEGRLSENF VCVGFARRPK 70 80 90 100 110 120 SHEQFREEMR QAIQNFSHSS EIDIRVWESL EHRIFYHQAN FSEAEGYSSL RSFLESVDQK 130 140 150 160 170 180 YGTKGNRLFY LSTPPDYFQE IIRNLNRHQL FYHEQGAQQP WSRLIIEKPF GVDLQTAQEL 190 200 210 220 230 240 QQCIDANINE ESVYRIDHYL GKETVQNILT IRFANTLFES CWNSQYIDHV QISVSESIGI 250 260 270 280 290 300 GSRGNFFEKS GMLRDMVQNH LMQLLCLLTM EPPSEFSSAE IKKEKIKILK KILPIREEDV 310 320 330 340 350 360 IRGQYGEGVV QGVSVSGYRE EENVDPNSLV ETYVALKLFI DNPRWKGVPF YLQAGKRLPK 370 380 390 400 410 420 RTTDIAVIFK KSSYDLFNSE NCPLCPLEND LLIIRIQPDE GVALQFNCKV PGTNKLVRPV 430 440 450 460 470 480 KMDFRYDSYF NTVTPEAYER LLCDCILGDR TLFTSNEEVL ASWELFSPLL EQWSKIRPIF 490 500 PNYIAGSLRP QGADELLSRD GRAWRSY

References

[1]

"Genome sequences of Chlamydia trachomatis MoPn and Chlamydia pneumoniae AR39." Read T.D., Brunham R.C., Shen C., Gill S.R., Heidelberg J.F., White O., Hickey E.K., Peterson J.D., Utterback T.R., Berry K.J., Bass S., Linher K.D., Weidman J.F., Khouri H.M., Craven B., Bowman C., Dodson R.J., Gwinn M.L. , Nelson W.C., DeBoy R.T., Kolonay J.F., McClarty G., Salzberg S.L., Eisen J.A., Fraser C.M. Nucleic Acids Res. 28:1397-1406(2000) [PubMed: 10684935] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MoPn / Nigg.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE002160 Genomic DNA. Translation: AAF73556.1.
RefSeq	NP_296834.1.
3D structure databases
HSSP	HSSP built from PDB template 1QKI based on UniProtKB P11413.
ModBase	Search...
Genome annotation databases
GeneID	1245812.
GenomeReviews	Gene locus TC_0457 in contig AE002160_GR.
KEGG	cmu:TC0457.
TIGR	TC_0457.
Phylogenomic databases
HOGENOM	Q9PKK8.
Enzyme and pathway databases
BioCyc	CMUR243161:TC_0457-MON.
Family and domain databases
InterPro	IPR001282. Glc-6-P_DHase. IPR016040. NAD(P)-bd. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHER	PTHR23429. G6PDH. 1 hit.
Pfam	PF02781. G6PD_C. 1 hit. PF00479. G6PD_N. 1 hit. [Graphical view]
PIRSF	PIRSF000110. G6PD. 1 hit.
PRINTS	PR00079. G6PDHDRGNASE.
ProDom	PD001129. G6PD. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00871. zwf. 1 hit.
PROSITE	PS00069. G6P_DEHYDROGENASE. 1 hit. [Graphical view]
BLOCKS	Search...
ProtoNet	Search...

Entry information

Entry name

G6PD_CHLMU

Accession

Primary (citable) accession number: Q9PKK8

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 2001
Last sequence update:	October 1, 2000
Last modified:	November 4, 2008
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)