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Q9PKK8

- G6PD_CHLMU

UniProt

Q9PKK8 - G6PD_CHLMU

Protein

Glucose-6-phosphate 1-dehydrogenase

Gene

zwf

Organism
Chlamydia muridarum (strain MoPn / Nigg)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.UniRule annotation

    Catalytic activityi

    D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei57 – 571NADPUniRule annotation
    Binding sitei168 – 1681NADPUniRule annotation
    Binding sitei198 – 1981SubstrateUniRule annotation
    Binding sitei202 – 2021SubstrateUniRule annotation
    Binding sitei236 – 2361SubstrateUniRule annotation
    Binding sitei255 – 2551SubstrateUniRule annotation
    Active sitei260 – 2601Proton acceptorUniRule annotation
    Binding sitei356 – 3561SubstrateUniRule annotation

    GO - Molecular functioni

    1. glucose-6-phosphate dehydrogenase activity Source: UniProtKB-HAMAP
    2. NADP binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. pentose-phosphate shunt Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Carbohydrate metabolism, Glucose metabolism

    Keywords - Ligandi

    NADP

    Enzyme and pathway databases

    BioCyciCMUR243161:GHYU-474-MONOMER.
    UniPathwayiUPA00115; UER00408.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glucose-6-phosphate 1-dehydrogenaseUniRule annotation (EC:1.1.1.49UniRule annotation)
    Short name:
    G6PDUniRule annotation
    Gene namesi
    Name:zwfUniRule annotation
    Ordered Locus Names:TC_0457
    OrganismiChlamydia muridarum (strain MoPn / Nigg)
    Taxonomic identifieri243161 [NCBI]
    Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
    ProteomesiUP000000800: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 507507Glucose-6-phosphate 1-dehydrogenasePRO_0000068115Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi243161.TC0457.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9PKK8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glucose-6-phosphate dehydrogenase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0364.
    KOiK00036.
    OMAiCIDANIN.
    OrthoDBiEOG61308Z.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    HAMAPiMF_00966. G6PD.
    InterProiIPR001282. G6P_DH.
    IPR019796. G6P_DH_AS.
    IPR022675. G6P_DH_C.
    IPR022674. G6P_DH_NAD-bd.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR23429. PTHR23429. 1 hit.
    PfamiPF02781. G6PD_C. 1 hit.
    PF00479. G6PD_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000110. G6PD. 1 hit.
    PRINTSiPR00079. G6PDHDRGNASE.
    TIGRFAMsiTIGR00871. zwf. 1 hit.
    PROSITEiPS00069. G6P_DEHYDROGENASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9PKK8-1 [UniParc]FASTAAdd to Basket

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    MEEIKEMGPT LPACPPCVMV IFGATGDLTA RKLFPALYNL TKEGRLSENF    50
    VCVGFARRPK SHEQFREEMR QAIQNFSHSS EIDIRVWESL EHRIFYHQAN 100
    FSEAEGYSSL RSFLESVDQK YGTKGNRLFY LSTPPDYFQE IIRNLNRHQL 150
    FYHEQGAQQP WSRLIIEKPF GVDLQTAQEL QQCIDANINE ESVYRIDHYL 200
    GKETVQNILT IRFANTLFES CWNSQYIDHV QISVSESIGI GSRGNFFEKS 250
    GMLRDMVQNH LMQLLCLLTM EPPSEFSSAE IKKEKIKILK KILPIREEDV 300
    IRGQYGEGVV QGVSVSGYRE EENVDPNSLV ETYVALKLFI DNPRWKGVPF 350
    YLQAGKRLPK RTTDIAVIFK KSSYDLFNSE NCPLCPLEND LLIIRIQPDE 400
    GVALQFNCKV PGTNKLVRPV KMDFRYDSYF NTVTPEAYER LLCDCILGDR 450
    TLFTSNEEVL ASWELFSPLL EQWSKIRPIF PNYIAGSLRP QGADELLSRD 500
    GRAWRSY 507
    Length:507
    Mass (Da):58,548
    Last modified:October 1, 2000 - v1
    Checksum:iC66F3FE1562391A6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE002160 Genomic DNA. Translation: AAF73556.1.
    RefSeqiNP_296834.1. NC_002620.2.

    Genome annotation databases

    EnsemblBacteriaiAAF73556; AAF73556; TC_0457.
    GeneIDi1245812.
    KEGGicmu:TC_0457.
    PATRICi20372332. VBIChlMur19118_0486.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE002160 Genomic DNA. Translation: AAF73556.1 .
    RefSeqi NP_296834.1. NC_002620.2.

    3D structure databases

    ProteinModelPortali Q9PKK8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 243161.TC0457.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAF73556 ; AAF73556 ; TC_0457 .
    GeneIDi 1245812.
    KEGGi cmu:TC_0457.
    PATRICi 20372332. VBIChlMur19118_0486.

    Phylogenomic databases

    eggNOGi COG0364.
    KOi K00036.
    OMAi CIDANIN.
    OrthoDBi EOG61308Z.

    Enzyme and pathway databases

    UniPathwayi UPA00115 ; UER00408 .
    BioCyci CMUR243161:GHYU-474-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    HAMAPi MF_00966. G6PD.
    InterProi IPR001282. G6P_DH.
    IPR019796. G6P_DH_AS.
    IPR022675. G6P_DH_C.
    IPR022674. G6P_DH_NAD-bd.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR23429. PTHR23429. 1 hit.
    Pfami PF02781. G6PD_C. 1 hit.
    PF00479. G6PD_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000110. G6PD. 1 hit.
    PRINTSi PR00079. G6PDHDRGNASE.
    TIGRFAMsi TIGR00871. zwf. 1 hit.
    PROSITEi PS00069. G6P_DEHYDROGENASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MoPn / Nigg.

    Entry informationi

    Entry nameiG6PD_CHLMU
    AccessioniPrimary (citable) accession number: Q9PKK8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 2001
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 91 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3