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Protein

Glucose-6-phosphate 1-dehydrogenase

Gene

zwf

Organism
Chlamydia muridarum (strain MoPn / Nigg)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.UniRule annotation

Catalytic activityi

D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH.UniRule annotation

Pathwayi: pentose phosphate pathway

This protein is involved in step 1 of the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage).UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Glucose-6-phosphate 1-dehydrogenase (zwf)
  2. 6-phosphogluconolactonase (pgl)
  3. 6-phosphogluconate dehydrogenase, decarboxylating (gnd)
This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei57NADPUniRule annotation1
Binding sitei168NADPUniRule annotation1
Binding sitei198SubstrateUniRule annotation1
Binding sitei202SubstrateUniRule annotation1
Binding sitei236SubstrateUniRule annotation1
Binding sitei255SubstrateUniRule annotation1
Active sitei260Proton acceptorUniRule annotation1
Binding sitei356SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processCarbohydrate metabolism, Glucose metabolism
LigandNADP

Enzyme and pathway databases

UniPathwayiUPA00115; UER00408

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate 1-dehydrogenaseUniRule annotation (EC:1.1.1.49UniRule annotation)
Short name:
G6PDUniRule annotation
Gene namesi
Name:zwfUniRule annotation
Ordered Locus Names:TC_0457
OrganismiChlamydia muridarum (strain MoPn / Nigg)
Taxonomic identifieri243161 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
Proteomesi
  • UP000000800 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000681151 – 507Glucose-6-phosphate 1-dehydrogenaseAdd BLAST507

Proteomic databases

PRIDEiQ9PKK8

Interactioni

Protein-protein interaction databases

STRINGi243161.CmurN_010100002308

Structurei

3D structure databases

ProteinModelPortaliQ9PKK8
SMRiQ9PKK8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glucose-6-phosphate dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105D8W Bacteria
COG0364 LUCA
KOiK00036
OMAiVEICVYE

Family and domain databases

HAMAPiMF_00966 G6PD, 1 hit
InterProiView protein in InterPro
IPR001282 G6P_DH
IPR019796 G6P_DH_AS
IPR022675 G6P_DH_C
IPR022674 G6P_DH_NAD-bd
IPR036291 NAD(P)-bd_dom_sf
PANTHERiPTHR23429 PTHR23429, 1 hit
PfamiView protein in Pfam
PF02781 G6PD_C, 1 hit
PF00479 G6PD_N, 1 hit
PIRSFiPIRSF000110 G6PD, 1 hit
PRINTSiPR00079 G6PDHDRGNASE
SUPFAMiSSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR00871 zwf, 1 hit
PROSITEiView protein in PROSITE
PS00069 G6P_DEHYDROGENASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q9PKK8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEIKEMGPT LPACPPCVMV IFGATGDLTA RKLFPALYNL TKEGRLSENF
60 70 80 90 100
VCVGFARRPK SHEQFREEMR QAIQNFSHSS EIDIRVWESL EHRIFYHQAN
110 120 130 140 150
FSEAEGYSSL RSFLESVDQK YGTKGNRLFY LSTPPDYFQE IIRNLNRHQL
160 170 180 190 200
FYHEQGAQQP WSRLIIEKPF GVDLQTAQEL QQCIDANINE ESVYRIDHYL
210 220 230 240 250
GKETVQNILT IRFANTLFES CWNSQYIDHV QISVSESIGI GSRGNFFEKS
260 270 280 290 300
GMLRDMVQNH LMQLLCLLTM EPPSEFSSAE IKKEKIKILK KILPIREEDV
310 320 330 340 350
IRGQYGEGVV QGVSVSGYRE EENVDPNSLV ETYVALKLFI DNPRWKGVPF
360 370 380 390 400
YLQAGKRLPK RTTDIAVIFK KSSYDLFNSE NCPLCPLEND LLIIRIQPDE
410 420 430 440 450
GVALQFNCKV PGTNKLVRPV KMDFRYDSYF NTVTPEAYER LLCDCILGDR
460 470 480 490 500
TLFTSNEEVL ASWELFSPLL EQWSKIRPIF PNYIAGSLRP QGADELLSRD

GRAWRSY
Length:507
Mass (Da):58,548
Last modified:October 1, 2000 - v1
Checksum:iC66F3FE1562391A6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE002160 Genomic DNA Translation: AAF73556.1

Genome annotation databases

EnsemblBacteriaiAAF73556; AAF73556; TC_0457
KEGGicmu:TC_0457

Similar proteinsi

Entry informationi

Entry nameiG6PD_CHLMU
AccessioniPrimary (citable) accession number: Q9PKK8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: October 1, 2000
Last modified: May 23, 2018
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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