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Q9PKK4

- GYRA_CHLMU

UniProt

Q9PKK4 - GYRA_CHLMU

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Protein

DNA gyrase subunit A

Gene

gyrA

Organism
Chlamydia muridarum (strain MoPn / Nigg)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings.UniRule annotation

Catalytic activityi

ATP-dependent breakage, passage and rejoining of double-stranded DNA.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei122 – 1221O-(5'-phospho-DNA)-tyrosine intermediateUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. DNA binding Source: UniProtKB-HAMAP
  3. DNA topoisomerase type II (ATP-hydrolyzing) activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. DNA-dependent DNA replication Source: UniProtKB-HAMAP
  2. DNA topological change Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Isomerase, Topoisomerase

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCMUR243161:GHYU-478-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA gyrase subunit AUniRule annotation (EC:5.99.1.3UniRule annotation)
Gene namesi
Name:gyrAUniRule annotation
Ordered Locus Names:TC_0461
OrganismiChlamydia muridarum (strain MoPn / Nigg)
Taxonomic identifieri243161 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
ProteomesiUP000000800: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. chromosome Source: InterPro
  2. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 833833DNA gyrase subunit APRO_0000145228Add
BLAST

Proteomic databases

PRIDEiQ9PKK4.

Interactioni

Subunit structurei

Heterotetramer, composed of two GyrA and two GyrB chains. Within the heterotetramer, GyrA contains the active site tyrosine that forms a covalent intermediate with the DNA, while GyrB contributes the cofactor binding sites and catalyzes ATP hydrolysis.UniRule annotation

Protein-protein interaction databases

STRINGi243161.TC0461.

Structurei

3D structure databases

ProteinModelPortaliQ9PKK4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the topoisomerase GyrA/ParC subunit family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0188.
KOiK02469.
OMAiMPIKVFR.
OrthoDBiEOG661H5V.

Family and domain databases

Gene3Di3.30.1360.40. 1 hit.
3.90.199.10. 2 hits.
HAMAPiMF_01897. GyrA.
InterProiIPR024946. Arg_repress_C-like.
IPR005743. GyrA.
IPR006691. GyrA/parC_pinwhl.
IPR002205. Topo_IIA_A/C.
IPR013758. Topo_IIA_A/C_ab.
IPR013760. Topo_IIA_like_dom.
[Graphical view]
PfamiPF03989. DNA_gyraseA_C. 6 hits.
PF00521. DNA_topoisoIV. 1 hit.
[Graphical view]
SMARTiSM00434. TOP4c. 1 hit.
[Graphical view]
SUPFAMiSSF56719. SSF56719. 1 hit.
TIGRFAMsiTIGR01063. gyrA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9PKK4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLNKEEIIVP KNLEEEMKES YLRYSMSVII SRALPDVRDG LKPSQRRILY
60 70 80 90 100
AMKQLNLTPG AKHRKCAKIC GDTSGDYHPH GEAVIYPTLV RMAQDWAMRY
110 120 130 140 150
PLVDGQGNFG SIDGDPAAAM RYTEARLTHS SIFLLEDLDK DTVDMVPNYD
160 170 180 190 200
ETKYEPVVFP SKFPNLLCNG SSGIAVGMAT NIPPHNLGEL IEATLLVLAN
210 220 230 240 250
PQTSIEEILE VMPGPDFPTG GIICGTEGIR STYYTGRGKL RLRARIHVEE
260 270 280 290 300
NSDKQRENII LTEMPYNVNK SRLVEQIAEL INEKTLTGIS DVRDESDKDG
310 320 330 340 350
IRVVLELKKG ESSEVIINRL YKFTDVQVTF GANMLALDKN LPRTMSIHRM
360 370 380 390 400
ISAWIRHRMD VIRRRTRYEL NKAETRAHIL EGFLKALSCM DEVVKTIRES
410 420 430 440 450
SNKEHAKQQL VELFGFSEAQ SLAILELRLY QLTGLEIDKV QKEYNELLEK
460 470 480 490 500
IAYYRRVLAE EELVKDIIRE ELQELHKVHK TPRRTTIEMD AGDVRDIEDI
510 520 530 540 550
IADESVIITI SGDDYVKRMP VKVFREQKRG GQGVTGFDMK KGSDFLKAVY
560 570 580 590 600
SASTKDYLLI FTNMGQCYWL KVWQLPEGER RAKGKPIINF LEGIRPGEQV
610 620 630 640 650
AAVLNVKRFE QGEYLLLATK KGVVKKVSLD AFGSPRKKGI RALEIDDGDE
660 670 680 690 700
LIAARHIVND EEKVMLFTRL GMAVRFPHDK VRPMGRAARG VRGVSLKNEE
710 720 730 740 750
DFVVSCQVVT DDQSVLVVCD NGFGKRSLVC DFRETNRGSV GVRSILINQR
760 770 780 790 800
NGDVLGAISV TDFDSILLMS AQGQAIRINM QDVRVMGRAT QGVRLVNLRE
810 820 830
GDTLVAMEKL SVNTESGETE ESVSIQVGHA VEE
Length:833
Mass (Da):93,884
Last modified:October 1, 2000 - v1
Checksum:iD168FE5950D8D221
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE002160 Genomic DNA. Translation: AAF39312.1.
PIRiH81700.
RefSeqiNP_296838.1. NC_002620.2.

Genome annotation databases

EnsemblBacteriaiAAF39312; AAF39312; TC_0461.
GeneIDi1245816.
KEGGicmu:TC_0461.
PATRICi20372340. VBIChlMur19118_0490.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE002160 Genomic DNA. Translation: AAF39312.1 .
PIRi H81700.
RefSeqi NP_296838.1. NC_002620.2.

3D structure databases

ProteinModelPortali Q9PKK4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243161.TC0461.

Proteomic databases

PRIDEi Q9PKK4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAF39312 ; AAF39312 ; TC_0461 .
GeneIDi 1245816.
KEGGi cmu:TC_0461.
PATRICi 20372340. VBIChlMur19118_0490.

Phylogenomic databases

eggNOGi COG0188.
KOi K02469.
OMAi MPIKVFR.
OrthoDBi EOG661H5V.

Enzyme and pathway databases

BioCyci CMUR243161:GHYU-478-MONOMER.

Family and domain databases

Gene3Di 3.30.1360.40. 1 hit.
3.90.199.10. 2 hits.
HAMAPi MF_01897. GyrA.
InterProi IPR024946. Arg_repress_C-like.
IPR005743. GyrA.
IPR006691. GyrA/parC_pinwhl.
IPR002205. Topo_IIA_A/C.
IPR013758. Topo_IIA_A/C_ab.
IPR013760. Topo_IIA_like_dom.
[Graphical view ]
Pfami PF03989. DNA_gyraseA_C. 6 hits.
PF00521. DNA_topoisoIV. 1 hit.
[Graphical view ]
SMARTi SM00434. TOP4c. 1 hit.
[Graphical view ]
SUPFAMi SSF56719. SSF56719. 1 hit.
TIGRFAMsi TIGR01063. gyrA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MoPn / Nigg.

Entry informationi

Entry nameiGYRA_CHLMU
AccessioniPrimary (citable) accession number: Q9PKK4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: October 1, 2000
Last modified: October 29, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3