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Q9PKK4

- GYRA_CHLMU

UniProt

Q9PKK4 - GYRA_CHLMU

Protein

DNA gyrase subunit A

Gene

gyrA

Organism
Chlamydia muridarum (strain MoPn / Nigg)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings.UniRule annotation

    Catalytic activityi

    ATP-dependent breakage, passage and rejoining of double-stranded DNA.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei122 – 1221O-(5'-phospho-DNA)-tyrosine intermediateUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. DNA binding Source: UniProtKB-HAMAP
    3. DNA topoisomerase type II (ATP-hydrolyzing) activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. DNA-dependent DNA replication Source: UniProtKB-HAMAP
    2. DNA topological change Source: InterPro

    Keywords - Molecular functioni

    Isomerase, Topoisomerase

    Keywords - Ligandi

    ATP-binding, DNA-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciCMUR243161:GHYU-478-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA gyrase subunit AUniRule annotation (EC:5.99.1.3UniRule annotation)
    Gene namesi
    Name:gyrAUniRule annotation
    Ordered Locus Names:TC_0461
    OrganismiChlamydia muridarum (strain MoPn / Nigg)
    Taxonomic identifieri243161 [NCBI]
    Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
    ProteomesiUP000000800: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. chromosome Source: InterPro
    2. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 833833DNA gyrase subunit APRO_0000145228Add
    BLAST

    Proteomic databases

    PRIDEiQ9PKK4.

    Interactioni

    Subunit structurei

    Heterotetramer, composed of two GyrA and two GyrB chains. Within the heterotetramer, GyrA contains the active site tyrosine that forms a covalent intermediate with the DNA, while GyrB contributes the cofactor binding sites and catalyzes ATP hydrolysis.UniRule annotation

    Protein-protein interaction databases

    STRINGi243161.TC0461.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9PKK4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the topoisomerase GyrA/ParC subunit family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0188.
    KOiK02469.
    OMAiMPIKVFR.
    OrthoDBiEOG661H5V.

    Family and domain databases

    Gene3Di3.30.1360.40. 1 hit.
    3.90.199.10. 2 hits.
    HAMAPiMF_01897. GyrA.
    InterProiIPR024946. Arg_repress_C-like.
    IPR005743. GyrA.
    IPR006691. GyrA/parC_pinwhl.
    IPR002205. Topo_IIA_A/C.
    IPR013758. Topo_IIA_A/C_ab.
    IPR013760. Topo_IIA_like_dom.
    [Graphical view]
    PfamiPF03989. DNA_gyraseA_C. 6 hits.
    PF00521. DNA_topoisoIV. 1 hit.
    [Graphical view]
    SMARTiSM00434. TOP4c. 1 hit.
    [Graphical view]
    SUPFAMiSSF56719. SSF56719. 1 hit.
    TIGRFAMsiTIGR01063. gyrA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9PKK4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLNKEEIIVP KNLEEEMKES YLRYSMSVII SRALPDVRDG LKPSQRRILY    50
    AMKQLNLTPG AKHRKCAKIC GDTSGDYHPH GEAVIYPTLV RMAQDWAMRY 100
    PLVDGQGNFG SIDGDPAAAM RYTEARLTHS SIFLLEDLDK DTVDMVPNYD 150
    ETKYEPVVFP SKFPNLLCNG SSGIAVGMAT NIPPHNLGEL IEATLLVLAN 200
    PQTSIEEILE VMPGPDFPTG GIICGTEGIR STYYTGRGKL RLRARIHVEE 250
    NSDKQRENII LTEMPYNVNK SRLVEQIAEL INEKTLTGIS DVRDESDKDG 300
    IRVVLELKKG ESSEVIINRL YKFTDVQVTF GANMLALDKN LPRTMSIHRM 350
    ISAWIRHRMD VIRRRTRYEL NKAETRAHIL EGFLKALSCM DEVVKTIRES 400
    SNKEHAKQQL VELFGFSEAQ SLAILELRLY QLTGLEIDKV QKEYNELLEK 450
    IAYYRRVLAE EELVKDIIRE ELQELHKVHK TPRRTTIEMD AGDVRDIEDI 500
    IADESVIITI SGDDYVKRMP VKVFREQKRG GQGVTGFDMK KGSDFLKAVY 550
    SASTKDYLLI FTNMGQCYWL KVWQLPEGER RAKGKPIINF LEGIRPGEQV 600
    AAVLNVKRFE QGEYLLLATK KGVVKKVSLD AFGSPRKKGI RALEIDDGDE 650
    LIAARHIVND EEKVMLFTRL GMAVRFPHDK VRPMGRAARG VRGVSLKNEE 700
    DFVVSCQVVT DDQSVLVVCD NGFGKRSLVC DFRETNRGSV GVRSILINQR 750
    NGDVLGAISV TDFDSILLMS AQGQAIRINM QDVRVMGRAT QGVRLVNLRE 800
    GDTLVAMEKL SVNTESGETE ESVSIQVGHA VEE 833
    Length:833
    Mass (Da):93,884
    Last modified:October 1, 2000 - v1
    Checksum:iD168FE5950D8D221
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE002160 Genomic DNA. Translation: AAF39312.1.
    PIRiH81700.
    RefSeqiNP_296838.1. NC_002620.2.

    Genome annotation databases

    EnsemblBacteriaiAAF39312; AAF39312; TC_0461.
    GeneIDi1245816.
    KEGGicmu:TC_0461.
    PATRICi20372340. VBIChlMur19118_0490.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE002160 Genomic DNA. Translation: AAF39312.1 .
    PIRi H81700.
    RefSeqi NP_296838.1. NC_002620.2.

    3D structure databases

    ProteinModelPortali Q9PKK4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 243161.TC0461.

    Proteomic databases

    PRIDEi Q9PKK4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAF39312 ; AAF39312 ; TC_0461 .
    GeneIDi 1245816.
    KEGGi cmu:TC_0461.
    PATRICi 20372340. VBIChlMur19118_0490.

    Phylogenomic databases

    eggNOGi COG0188.
    KOi K02469.
    OMAi MPIKVFR.
    OrthoDBi EOG661H5V.

    Enzyme and pathway databases

    BioCyci CMUR243161:GHYU-478-MONOMER.

    Family and domain databases

    Gene3Di 3.30.1360.40. 1 hit.
    3.90.199.10. 2 hits.
    HAMAPi MF_01897. GyrA.
    InterProi IPR024946. Arg_repress_C-like.
    IPR005743. GyrA.
    IPR006691. GyrA/parC_pinwhl.
    IPR002205. Topo_IIA_A/C.
    IPR013758. Topo_IIA_A/C_ab.
    IPR013760. Topo_IIA_like_dom.
    [Graphical view ]
    Pfami PF03989. DNA_gyraseA_C. 6 hits.
    PF00521. DNA_topoisoIV. 1 hit.
    [Graphical view ]
    SMARTi SM00434. TOP4c. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56719. SSF56719. 1 hit.
    TIGRFAMsi TIGR01063. gyrA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MoPn / Nigg.

    Entry informationi

    Entry nameiGYRA_CHLMU
    AccessioniPrimary (citable) accession number: Q9PKK4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 27, 2001
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 85 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3