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Q9PKK4 (GYRA_CHLMU) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
DNA gyrase subunit A
EC=5.99.1.3
Gene names
Name:gyrA
Ordered Locus Names:TC_0461
OrganismChlamydia muridarum (strain MoPn / Nigg) [Complete proteome] [HAMAP]
Taxonomic identifier243161 [NCBI]
Taxonomic lineageBacteria › Chlamydiae › Chlamydiales › Chlamydiaceae › Chlamydia/Chlamydophila group › Chlamydia ›

Protein attributes

Sequence length833 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings By similarity. HAMAP-Rule MF_01897

Catalytic activity

ATP-dependent breakage, passage and rejoining of double-stranded DNA. HAMAP-Rule MF_01897

Subunit structure

Heterotetramer, composed of two GyrA and two GyrB chains. Within the heterotetramer, GyrA contains the active site tyrosine that forms a covalent intermediate with the DNA, while GyrB contributes the cofactor binding sites and catalyzes ATP hydrolysis By similarity.

Subcellular location

Cytoplasm Potential HAMAP-Rule MF_01897.

Sequence similarities

Belongs to the topoisomerase GyrA/ParC subunit family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 833833DNA gyrase subunit A HAMAP-Rule MF_01897
PRO_0000145228

Sites

Active site1221O-(5'-phospho-DNA)-tyrosine intermediate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9PKK4 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: D168FE5950D8D221

FASTA83393,884
        10         20         30         40         50         60 
MLNKEEIIVP KNLEEEMKES YLRYSMSVII SRALPDVRDG LKPSQRRILY AMKQLNLTPG 

        70         80         90        100        110        120 
AKHRKCAKIC GDTSGDYHPH GEAVIYPTLV RMAQDWAMRY PLVDGQGNFG SIDGDPAAAM 

       130        140        150        160        170        180 
RYTEARLTHS SIFLLEDLDK DTVDMVPNYD ETKYEPVVFP SKFPNLLCNG SSGIAVGMAT 

       190        200        210        220        230        240 
NIPPHNLGEL IEATLLVLAN PQTSIEEILE VMPGPDFPTG GIICGTEGIR STYYTGRGKL 

       250        260        270        280        290        300 
RLRARIHVEE NSDKQRENII LTEMPYNVNK SRLVEQIAEL INEKTLTGIS DVRDESDKDG 

       310        320        330        340        350        360 
IRVVLELKKG ESSEVIINRL YKFTDVQVTF GANMLALDKN LPRTMSIHRM ISAWIRHRMD 

       370        380        390        400        410        420 
VIRRRTRYEL NKAETRAHIL EGFLKALSCM DEVVKTIRES SNKEHAKQQL VELFGFSEAQ 

       430        440        450        460        470        480 
SLAILELRLY QLTGLEIDKV QKEYNELLEK IAYYRRVLAE EELVKDIIRE ELQELHKVHK 

       490        500        510        520        530        540 
TPRRTTIEMD AGDVRDIEDI IADESVIITI SGDDYVKRMP VKVFREQKRG GQGVTGFDMK 

       550        560        570        580        590        600 
KGSDFLKAVY SASTKDYLLI FTNMGQCYWL KVWQLPEGER RAKGKPIINF LEGIRPGEQV 

       610        620        630        640        650        660 
AAVLNVKRFE QGEYLLLATK KGVVKKVSLD AFGSPRKKGI RALEIDDGDE LIAARHIVND 

       670        680        690        700        710        720 
EEKVMLFTRL GMAVRFPHDK VRPMGRAARG VRGVSLKNEE DFVVSCQVVT DDQSVLVVCD 

       730        740        750        760        770        780 
NGFGKRSLVC DFRETNRGSV GVRSILINQR NGDVLGAISV TDFDSILLMS AQGQAIRINM 

       790        800        810        820        830 
QDVRVMGRAT QGVRLVNLRE GDTLVAMEKL SVNTESGETE ESVSIQVGHA VEE

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE002160 Genomic DNA. Translation: AAF39312.1.
PIRH81700.
RefSeqNP_296838.1. NC_002620.2.

3D structure databases

ProteinModelPortalQ9PKK4.
ModBaseSearch...

Protein-protein interaction databases

STRING243161.TC0461.

Proteomic databases

PRIDEQ9PKK4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAF39312; AAF39312; TC_0461.
GeneID1245816.
KEGGcmu:TC0461.
PATRIC20372340. VBIChlMur19118_0490.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0188.
KOK02469.
OMAIAQEDVV.
ProtClustDBPRK05560.

Enzyme and pathway databases

BioCycCMUR243161:GHYU-454-MONOMER.

Family and domain databases

Gene3D3.30.1360.40. 1 hit.
3.90.199.10. 2 hits.
HAMAPMF_01897. GyrA.
InterProIPR024946. Arg_repress_C-like.
IPR005743. GyrA.
IPR006691. GyrA/parC_pinwhl.
IPR002205. Topo_IIA_A/C.
IPR013758. Topo_IIA_A/C_ab.
IPR013760. Topo_IIA_like_dom.
[Graphical view]
PfamPF03989. DNA_gyraseA_C. 6 hits.
PF00521. DNA_topoisoIV. 1 hit.
[Graphical view]
SMARTSM00434. TOP4c. 1 hit.
[Graphical view]
SUPFAMSSF56719. Topo_IIA_cen. 1 hit.
TIGRFAMsTIGR01063. gyrA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGYRA_CHLMU
AccessionPrimary (citable) accession number: Q9PKK4
Entry history
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: October 1, 2000
Last modified: May 1, 2013
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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