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Q9PKI4

- SYL_CHLMU

UniProt

Q9PKI4 - SYL_CHLMU

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Chlamydia muridarum (strain MoPn / Nigg)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei603 – 6031ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciCMUR243161:GHYU-500-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:TC_0481
    OrganismiChlamydia muridarum (strain MoPn / Nigg)
    Taxonomic identifieri243161 [NCBI]
    Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
    ProteomesiUP000000800: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 819819Leucine--tRNA ligasePRO_0000151997Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi243161.TC0481.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9PKI4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi40 – 5112"HIGH" regionAdd
    BLAST
    Motifi600 – 6045"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    KOiK01869.
    OMAiERYWMNV.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9PKI4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRYDPSLIEE KWQKFWKEEQ TFRAEEDETK TKYYVLDMFP YPSGAGLHVG    50
    HLIGYTATDI VARYKRAKGF SVLHPMGWDS FGLPAEQYAI RTGTHPRETT 100
    EKNIANFKQQ LTSMGFSYDE SREFATSDPE YYKWTQKLFL ILYEKGLAYM 150
    ADMAVNYCPE LGTVLSNEEV ENGFSVEGGY PVERRMLRQW VLRITAFADQ 200
    LLGGLDELDW PESVKQLQRN WIGKSVGASV HFETEHGVLE VFTTRPDTLI 250
    GVSFLVLAPE HPLVDLLTSD EQKTIVAQYV KETQSKSERD RISEMKTKSG 300
    VFTGAYAKHP VTQNPIPIWI ADYVLMGYGS GAVMGVPAHD DRDLLFAQQF 350
    DLPIISVVSE DGVCINSCHE DFSLDGLSGE EAKQYVINFL EKNNLGSAKV 400
    AYKLRDWLFS RQRYWGEPIP VIHFEDGSCR PLKDDELPLL PPEIQDYRPE 450
    GVGQGPLAKV KEWVNVFDSE TQKEGKRETH TMPQWAGSCW YYLRFCDAHN 500
    SCAPWAEEKE QYWMPVDLYI GGAEHAVLHL LYARFWHQVF YEAGIVSTPE 550
    PFKKLVNQGL VLSTSYRIPG KGYIAPEMAK EENGQWISPS GELLDVRQEK 600
    MSKSKLNGVD PKVLIDEFGA DAVRMYAMFS GPLDKNKLWS NQGVAGCRRF 650
    LNRFYEMATS SRVKDEDIFE GMSLAHKLVQ RVTDDIEKLS LNTITSSFME 700
    FINEFVKLPV YPKNAVEMAV RALAPIAPHI SEELWVLLGN ASGIEKAGWP 750
    KALPEYLEGK IVTIVVQVNG KLRARLDISK DAIEEEVVAL AKEAVSKYLE 800
    GGVVRKTIFV LNRLVNFVI 819
    Length:819
    Mass (Da):93,015
    Last modified:October 1, 2000 - v1
    Checksum:i024D7E1BD2E900B4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE002160 Genomic DNA. Translation: AAF39327.1.
    PIRiG81698.
    RefSeqiNP_296858.1. NC_002620.2.

    Genome annotation databases

    EnsemblBacteriaiAAF39327; AAF39327; TC_0481.
    GeneIDi1245839.
    KEGGicmu:TC_0481.
    PATRICi20372394. VBIChlMur19118_0515.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE002160 Genomic DNA. Translation: AAF39327.1 .
    PIRi G81698.
    RefSeqi NP_296858.1. NC_002620.2.

    3D structure databases

    ProteinModelPortali Q9PKI4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 243161.TC0481.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAF39327 ; AAF39327 ; TC_0481 .
    GeneIDi 1245839.
    KEGGi cmu:TC_0481.
    PATRICi 20372394. VBIChlMur19118_0515.

    Phylogenomic databases

    eggNOGi COG0495.
    KOi K01869.
    OMAi ERYWMNV.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci CMUR243161:GHYU-500-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MoPn / Nigg.

    Entry informationi

    Entry nameiSYL_CHLMU
    AccessioniPrimary (citable) accession number: Q9PKI4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 27, 2001
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 94 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3