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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Chlamydia muridarum (strain MoPn / Nigg)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei603ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:TC_0481
OrganismiChlamydia muridarum (strain MoPn / Nigg)
Taxonomic identifieri243161 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
Proteomesi
  • UP000000800 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001519971 – 819Leucine--tRNA ligaseAdd BLAST819

Proteomic databases

PRIDEiQ9PKI4

Interactioni

Protein-protein interaction databases

STRINGi243161.CmurN_010100002438

Structurei

3D structure databases

ProteinModelPortaliQ9PKI4
SMRiQ9PKI4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi40 – 51"HIGH" regionAdd BLAST12
Motifi600 – 604"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C8T Bacteria
COG0495 LUCA
KOiK01869
OMAiTFMVLAP

Family and domain databases

Gene3Di3.40.50.620, 2 hits
3.90.740.10, 1 hit
HAMAPiMF_00049_B Leu_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002302 Leu-tRNA-ligase
IPR025709 Leu_tRNA-synth_edit
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR015413 Methionyl/Leucyl_tRNA_Synth
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR43740 PTHR43740, 1 hit
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF13603 tRNA-synt_1_2, 1 hit
PF09334 tRNA-synt_1g, 2 hits
PRINTSiPR00985 TRNASYNTHLEU
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 1 hit
TIGRFAMsiTIGR00396 leuS_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

Q9PKI4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRYDPSLIEE KWQKFWKEEQ TFRAEEDETK TKYYVLDMFP YPSGAGLHVG
60 70 80 90 100
HLIGYTATDI VARYKRAKGF SVLHPMGWDS FGLPAEQYAI RTGTHPRETT
110 120 130 140 150
EKNIANFKQQ LTSMGFSYDE SREFATSDPE YYKWTQKLFL ILYEKGLAYM
160 170 180 190 200
ADMAVNYCPE LGTVLSNEEV ENGFSVEGGY PVERRMLRQW VLRITAFADQ
210 220 230 240 250
LLGGLDELDW PESVKQLQRN WIGKSVGASV HFETEHGVLE VFTTRPDTLI
260 270 280 290 300
GVSFLVLAPE HPLVDLLTSD EQKTIVAQYV KETQSKSERD RISEMKTKSG
310 320 330 340 350
VFTGAYAKHP VTQNPIPIWI ADYVLMGYGS GAVMGVPAHD DRDLLFAQQF
360 370 380 390 400
DLPIISVVSE DGVCINSCHE DFSLDGLSGE EAKQYVINFL EKNNLGSAKV
410 420 430 440 450
AYKLRDWLFS RQRYWGEPIP VIHFEDGSCR PLKDDELPLL PPEIQDYRPE
460 470 480 490 500
GVGQGPLAKV KEWVNVFDSE TQKEGKRETH TMPQWAGSCW YYLRFCDAHN
510 520 530 540 550
SCAPWAEEKE QYWMPVDLYI GGAEHAVLHL LYARFWHQVF YEAGIVSTPE
560 570 580 590 600
PFKKLVNQGL VLSTSYRIPG KGYIAPEMAK EENGQWISPS GELLDVRQEK
610 620 630 640 650
MSKSKLNGVD PKVLIDEFGA DAVRMYAMFS GPLDKNKLWS NQGVAGCRRF
660 670 680 690 700
LNRFYEMATS SRVKDEDIFE GMSLAHKLVQ RVTDDIEKLS LNTITSSFME
710 720 730 740 750
FINEFVKLPV YPKNAVEMAV RALAPIAPHI SEELWVLLGN ASGIEKAGWP
760 770 780 790 800
KALPEYLEGK IVTIVVQVNG KLRARLDISK DAIEEEVVAL AKEAVSKYLE
810
GGVVRKTIFV LNRLVNFVI
Length:819
Mass (Da):93,015
Last modified:October 1, 2000 - v1
Checksum:i024D7E1BD2E900B4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE002160 Genomic DNA Translation: AAF39327.1
PIRiG81698
RefSeqiWP_010230558.1, NZ_ACOV01000003.1

Genome annotation databases

EnsemblBacteriaiAAF39327; AAF39327; TC_0481
GeneIDi1245839
KEGGicmu:TC_0481

Similar proteinsi

Entry informationi

Entry nameiSYL_CHLMU
AccessioniPrimary (citable) accession number: Q9PKI4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: October 1, 2000
Last modified: May 23, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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