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Q9PKI4 (SYL_CHLMU) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 93. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Leucine--tRNA ligase

EC=6.1.1.4
Alternative name(s):
Leucyl-tRNA synthetase
Short name=LeuRS
Gene names
Name:leuS
Ordered Locus Names:TC_0481
OrganismChlamydia muridarum (strain MoPn / Nigg) [Complete proteome] [HAMAP]
Taxonomic identifier243161 [NCBI]
Taxonomic lineageBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia

Protein attributes

Sequence length819 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu). HAMAP-Rule MF_00049

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00049.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processleucyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

aminoacyl-tRNA editing activity

Inferred from electronic annotation. Source: InterPro

leucine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 819819Leucine--tRNA ligase HAMAP-Rule MF_00049
PRO_0000151997

Regions

Motif40 – 5112"HIGH" region HAMAP-Rule MF_00049
Motif600 – 6045"KMSKS" region HAMAP-Rule MF_00049

Sites

Binding site6031ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9PKI4 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: 024D7E1BD2E900B4

FASTA81993,015
        10         20         30         40         50         60 
MRYDPSLIEE KWQKFWKEEQ TFRAEEDETK TKYYVLDMFP YPSGAGLHVG HLIGYTATDI 

        70         80         90        100        110        120 
VARYKRAKGF SVLHPMGWDS FGLPAEQYAI RTGTHPRETT EKNIANFKQQ LTSMGFSYDE 

       130        140        150        160        170        180 
SREFATSDPE YYKWTQKLFL ILYEKGLAYM ADMAVNYCPE LGTVLSNEEV ENGFSVEGGY 

       190        200        210        220        230        240 
PVERRMLRQW VLRITAFADQ LLGGLDELDW PESVKQLQRN WIGKSVGASV HFETEHGVLE 

       250        260        270        280        290        300 
VFTTRPDTLI GVSFLVLAPE HPLVDLLTSD EQKTIVAQYV KETQSKSERD RISEMKTKSG 

       310        320        330        340        350        360 
VFTGAYAKHP VTQNPIPIWI ADYVLMGYGS GAVMGVPAHD DRDLLFAQQF DLPIISVVSE 

       370        380        390        400        410        420 
DGVCINSCHE DFSLDGLSGE EAKQYVINFL EKNNLGSAKV AYKLRDWLFS RQRYWGEPIP 

       430        440        450        460        470        480 
VIHFEDGSCR PLKDDELPLL PPEIQDYRPE GVGQGPLAKV KEWVNVFDSE TQKEGKRETH 

       490        500        510        520        530        540 
TMPQWAGSCW YYLRFCDAHN SCAPWAEEKE QYWMPVDLYI GGAEHAVLHL LYARFWHQVF 

       550        560        570        580        590        600 
YEAGIVSTPE PFKKLVNQGL VLSTSYRIPG KGYIAPEMAK EENGQWISPS GELLDVRQEK 

       610        620        630        640        650        660 
MSKSKLNGVD PKVLIDEFGA DAVRMYAMFS GPLDKNKLWS NQGVAGCRRF LNRFYEMATS 

       670        680        690        700        710        720 
SRVKDEDIFE GMSLAHKLVQ RVTDDIEKLS LNTITSSFME FINEFVKLPV YPKNAVEMAV 

       730        740        750        760        770        780 
RALAPIAPHI SEELWVLLGN ASGIEKAGWP KALPEYLEGK IVTIVVQVNG KLRARLDISK 

       790        800        810 
DAIEEEVVAL AKEAVSKYLE GGVVRKTIFV LNRLVNFVI 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE002160 Genomic DNA. Translation: AAF39327.1.
PIRG81698.
RefSeqNP_296858.1. NC_002620.2.

3D structure databases

ProteinModelPortalQ9PKI4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING243161.TC0481.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAF39327; AAF39327; TC_0481.
GeneID1245839.
KEGGcmu:TC_0481.
PATRIC20372394. VBIChlMur19118_0515.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0495.
KOK01869.
OMAERYWMNV.
OrthoDBEOG63Z74X.

Enzyme and pathway databases

BioCycCMUR243161:GHYU-500-MONOMER.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPMF_00049_B. Leu_tRNA_synth_B.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSPR00985. TRNASYNTHLEU.
SUPFAMSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsTIGR00396. leuS_bact. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYL_CHLMU
AccessionPrimary (citable) accession number: Q9PKI4
Entry history
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: October 1, 2000
Last modified: May 14, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries