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Q9PKI4

- SYL_CHLMU

UniProt

Q9PKI4 - SYL_CHLMU

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Protein

Leucine--tRNA ligase

Gene
leuS, TC_0481
Organism
Chlamydia muridarum (strain MoPn / Nigg)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei603 – 6031ATP By similarity

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCMUR243161:GHYU-500-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:TC_0481
OrganismiChlamydia muridarum (strain MoPn / Nigg)
Taxonomic identifieri243161 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
ProteomesiUP000000800: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 819819Leucine--tRNA ligaseUniRule annotationPRO_0000151997Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi243161.TC0481.

Structurei

3D structure databases

ProteinModelPortaliQ9PKI4.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi40 – 5112"HIGH" regionUniRule annotationAdd
BLAST
Motifi600 – 6045"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
KOiK01869.
OMAiERYWMNV.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9PKI4-1 [UniParc]FASTAAdd to Basket

« Hide

MRYDPSLIEE KWQKFWKEEQ TFRAEEDETK TKYYVLDMFP YPSGAGLHVG    50
HLIGYTATDI VARYKRAKGF SVLHPMGWDS FGLPAEQYAI RTGTHPRETT 100
EKNIANFKQQ LTSMGFSYDE SREFATSDPE YYKWTQKLFL ILYEKGLAYM 150
ADMAVNYCPE LGTVLSNEEV ENGFSVEGGY PVERRMLRQW VLRITAFADQ 200
LLGGLDELDW PESVKQLQRN WIGKSVGASV HFETEHGVLE VFTTRPDTLI 250
GVSFLVLAPE HPLVDLLTSD EQKTIVAQYV KETQSKSERD RISEMKTKSG 300
VFTGAYAKHP VTQNPIPIWI ADYVLMGYGS GAVMGVPAHD DRDLLFAQQF 350
DLPIISVVSE DGVCINSCHE DFSLDGLSGE EAKQYVINFL EKNNLGSAKV 400
AYKLRDWLFS RQRYWGEPIP VIHFEDGSCR PLKDDELPLL PPEIQDYRPE 450
GVGQGPLAKV KEWVNVFDSE TQKEGKRETH TMPQWAGSCW YYLRFCDAHN 500
SCAPWAEEKE QYWMPVDLYI GGAEHAVLHL LYARFWHQVF YEAGIVSTPE 550
PFKKLVNQGL VLSTSYRIPG KGYIAPEMAK EENGQWISPS GELLDVRQEK 600
MSKSKLNGVD PKVLIDEFGA DAVRMYAMFS GPLDKNKLWS NQGVAGCRRF 650
LNRFYEMATS SRVKDEDIFE GMSLAHKLVQ RVTDDIEKLS LNTITSSFME 700
FINEFVKLPV YPKNAVEMAV RALAPIAPHI SEELWVLLGN ASGIEKAGWP 750
KALPEYLEGK IVTIVVQVNG KLRARLDISK DAIEEEVVAL AKEAVSKYLE 800
GGVVRKTIFV LNRLVNFVI 819
Length:819
Mass (Da):93,015
Last modified:October 1, 2000 - v1
Checksum:i024D7E1BD2E900B4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE002160 Genomic DNA. Translation: AAF39327.1.
PIRiG81698.
RefSeqiNP_296858.1. NC_002620.2.

Genome annotation databases

EnsemblBacteriaiAAF39327; AAF39327; TC_0481.
GeneIDi1245839.
KEGGicmu:TC_0481.
PATRICi20372394. VBIChlMur19118_0515.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE002160 Genomic DNA. Translation: AAF39327.1 .
PIRi G81698.
RefSeqi NP_296858.1. NC_002620.2.

3D structure databases

ProteinModelPortali Q9PKI4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243161.TC0481.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAF39327 ; AAF39327 ; TC_0481 .
GeneIDi 1245839.
KEGGi cmu:TC_0481.
PATRICi 20372394. VBIChlMur19118_0515.

Phylogenomic databases

eggNOGi COG0495.
KOi K01869.
OMAi ERYWMNV.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci CMUR243161:GHYU-500-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MoPn / Nigg.

Entry informationi

Entry nameiSYL_CHLMU
AccessioniPrimary (citable) accession number: Q9PKI4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: October 1, 2000
Last modified: May 14, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi