Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

3-oxoacyl-[acyl-carrier-protein] reductase FabG

Gene

fabG

Organism
Chlamydia muridarum (strain MoPn / Nigg)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis.By similarity

Catalytic activityi

(3R)-3-hydroxyacyl-[acyl-carrier-protein] + NADP+ = 3-oxoacyl-[acyl-carrier-protein] + NADPH.

Pathwayi: fatty acid biosynthesis

This protein is involved in the pathway fatty acid biosynthesis, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway fatty acid biosynthesis and in Lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei92NADP; via carbonyl oxygenBy similarity1
Binding sitei144SubstrateBy similarity1
Active sitei157Proton acceptorPROSITE-ProRule annotation1
Binding sitei190NADP; via amide nitrogen and carbonyl oxygenBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi14 – 17NADPBy similarity4
Nucleotide bindingi65 – 66NADPBy similarity2
Nucleotide bindingi157 – 161NADPBy similarity5

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processFatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism
LigandNADP

Enzyme and pathway databases

UniPathwayiUPA00094

Names & Taxonomyi

Protein namesi
Recommended name:
3-oxoacyl-[acyl-carrier-protein] reductase FabG (EC:1.1.1.100)
Alternative name(s):
3-ketoacyl-acyl carrier protein reductase
Beta-Ketoacyl-acyl carrier protein reductase
Beta-ketoacyl-ACP reductase
Gene namesi
Name:fabG
Ordered Locus Names:TC_0508
OrganismiChlamydia muridarum (strain MoPn / Nigg)
Taxonomic identifieri243161 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
Proteomesi
  • UP000000800 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000546691 – 2483-oxoacyl-[acyl-carrier-protein] reductase FabGAdd BLAST248

Proteomic databases

PRIDEiQ9PKF7

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

STRINGi243161.CmurN_010100002593

Structurei

3D structure databases

ProteinModelPortaliQ9PKF7
SMRiQ9PKF7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105CHR Bacteria
ENOG410XNW1 LUCA
KOiK00059
OMAiGSRNIRC

Family and domain databases

InterProiView protein in InterPro
IPR011284 3oxo_ACP_reduc
IPR036291 NAD(P)-bd_dom_sf
IPR020904 Sc_DH/Rdtase_CS
IPR002347 SDR_fam
PRINTSiPR00081 GDHRDH
PR00080 SDRFAMILY
SUPFAMiSSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR01830 3oxo_ACP_reduc, 1 hit
PROSITEiView protein in PROSITE
PS00061 ADH_SHORT, 1 hit

Sequencei

Sequence statusi: Complete.

Q9PKF7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSLLVNKAA IVTGGSRGIG FGIAKLFAEH GANVQIWGIN EEAGKSAAQD
60 70 80 90 100
LSDKTGSKVS FALVDVSKND MVSAQVQKFL AEYGTIDVVV NNAGITRDSL
110 120 130 140 150
LMRMSEEEWS SVIDTNLGSI YNVCSAVIRP MIKARSGAIV NISSIVGLRG
160 170 180 190 200
SPGQTNYAAA KAGIIGFSKA LSKEVGSKNI RVNCIAPGFI DTDMTKGLSD
210 220 230 240
NLKNEWLKGV PLGRVGTPEE IAMAALFLAS NQSSYITGQV LSVDGGMA
Length:248
Mass (Da):25,977
Last modified:October 1, 2000 - v1
Checksum:i1F5C8968CB05FF58
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE002160 Genomic DNA Translation: AAF39350.1
PIRiE81695
RefSeqiWP_010230638.1, NZ_ACOV01000003.1

Genome annotation databases

EnsemblBacteriaiAAF39350; AAF39350; TC_0508
GeneIDi1245868
KEGGicmu:TC_0508

Similar proteinsi

Entry informationi

Entry nameiFABG_CHLMU
AccessioniPrimary (citable) accession number: Q9PKF7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: October 1, 2000
Last modified: March 28, 2018
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health