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Protein

3-oxoacyl-[acyl-carrier-protein] reductase FabG

Gene

fabG

Organism
Chlamydia muridarum (strain MoPn / Nigg)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis.By similarity

Catalytic activityi

(3R)-3-hydroxyacyl-[acyl-carrier-protein] + NADP+ = 3-oxoacyl-[acyl-carrier-protein] + NADPH.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei92 – 921NADP; via carbonyl oxygenBy similarity
Binding sitei144 – 1441SubstrateBy similarity
Active sitei157 – 1571Proton acceptorPROSITE-ProRule annotation
Binding sitei190 – 1901NADP; via amide nitrogen and carbonyl oxygenBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi14 – 174NADPBy similarity
Nucleotide bindingi65 – 662NADPBy similarity
Nucleotide bindingi157 – 1615NADPBy similarity

GO - Molecular functioni

  1. 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity Source: UniProtKB-EC
  2. NAD binding Source: InterPro

GO - Biological processi

  1. fatty acid biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Keywords - Ligandi

NADP

Enzyme and pathway databases

BioCyciCMUR243161:GHYU-529-MONOMER.
UniPathwayiUPA00094.

Names & Taxonomyi

Protein namesi
Recommended name:
3-oxoacyl-[acyl-carrier-protein] reductase FabG (EC:1.1.1.100)
Alternative name(s):
3-ketoacyl-acyl carrier protein reductase
Beta-Ketoacyl-acyl carrier protein reductase
Beta-ketoacyl-ACP reductase
Gene namesi
Name:fabG
Ordered Locus Names:TC_0508
OrganismiChlamydia muridarum (strain MoPn / Nigg)
Taxonomic identifieri243161 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
ProteomesiUP000000800 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2482483-oxoacyl-[acyl-carrier-protein] reductase FabGPRO_0000054669Add
BLAST

Proteomic databases

PRIDEiQ9PKF7.

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

STRINGi243161.TC0508.

Structurei

3D structure databases

ProteinModelPortaliQ9PKF7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1028.
KOiK00059.
OMAiVAHKFAS.
OrthoDBiEOG6N3CR8.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR011284. 3oxo_ACP_reduc.
IPR002198. DH_sc/Rdtase_SDR.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
[Graphical view]
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
TIGRFAMsiTIGR01830. 3oxo_ACP_reduc. 1 hit.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9PKF7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSLLVNKAA IVTGGSRGIG FGIAKLFAEH GANVQIWGIN EEAGKSAAQD
60 70 80 90 100
LSDKTGSKVS FALVDVSKND MVSAQVQKFL AEYGTIDVVV NNAGITRDSL
110 120 130 140 150
LMRMSEEEWS SVIDTNLGSI YNVCSAVIRP MIKARSGAIV NISSIVGLRG
160 170 180 190 200
SPGQTNYAAA KAGIIGFSKA LSKEVGSKNI RVNCIAPGFI DTDMTKGLSD
210 220 230 240
NLKNEWLKGV PLGRVGTPEE IAMAALFLAS NQSSYITGQV LSVDGGMA
Length:248
Mass (Da):25,977
Last modified:September 30, 2000 - v1
Checksum:i1F5C8968CB05FF58
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE002160 Genomic DNA. Translation: AAF39350.1.
PIRiE81695.
RefSeqiNP_296885.1. NC_002620.2.

Genome annotation databases

EnsemblBacteriaiAAF39350; AAF39350; TC_0508.
KEGGicmu:TC_0508.
PATRICi20372460. VBIChlMur19118_0546.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE002160 Genomic DNA. Translation: AAF39350.1.
PIRiE81695.
RefSeqiNP_296885.1. NC_002620.2.

3D structure databases

ProteinModelPortaliQ9PKF7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243161.TC0508.

Proteomic databases

PRIDEiQ9PKF7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAF39350; AAF39350; TC_0508.
KEGGicmu:TC_0508.
PATRICi20372460. VBIChlMur19118_0546.

Phylogenomic databases

eggNOGiCOG1028.
KOiK00059.
OMAiVAHKFAS.
OrthoDBiEOG6N3CR8.

Enzyme and pathway databases

UniPathwayiUPA00094.
BioCyciCMUR243161:GHYU-529-MONOMER.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR011284. 3oxo_ACP_reduc.
IPR002198. DH_sc/Rdtase_SDR.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
[Graphical view]
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
TIGRFAMsiTIGR01830. 3oxo_ACP_reduc. 1 hit.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MoPn / Nigg.

Entry informationi

Entry nameiFABG_CHLMU
AccessioniPrimary (citable) accession number: Q9PKF7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2001
Last sequence update: September 30, 2000
Last modified: March 31, 2015
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.