Q9PK92 (PKND_CHLMU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Serine/threonine-protein kinase PknD
EC=2.7.11.1

Gene names

Name:	pknD
Ordered Locus Names:	TC_0575

Organism

Chlamydia muridarum (strain MoPn / Nigg) [Complete proteome] [HAMAP]

Taxonomic identifier

243161 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Chlamydiae/Verrucomicrobia group › Chlamydiae › Chlamydiia › Chlamydiales › Chlamydiaceae › Chlamydia/Chlamydophila group › Chlamydia › Chlamydia muridarum

Protein attributes

Sequence length	934 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Together with the serine/threonine kinase pkn1, may play a role in the specific interactions with host proteins during intracellular growth By similarity. HAMAP-Rule MF_01957
Catalytic activity	ATP + a protein = ADP + a phosphoprotein. HAMAP-Rule MF_01957
Post-translational modification	Autophosphorylated on serine and threonine residues By similarity. HAMAP-Rule MF_01957
Sequence similarities	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Contains 1 protein kinase domain.

Ontologies

Keywords
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Molecular_function	ATP binding Inferred from electronic annotation. Source: HAMAP protein serine/threonine kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 934	934	Serine/threonine-protein kinase PknD HAMAP-Rule MF_01957		PRO_0000171191
Regions
	Domain	4 – 296	293	Protein kinase
	Nucleotide binding	10 – 18	9	ATP By similarity
Sites
	Active site	138	1	Proton acceptor By similarity
	Binding site	33	1	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9PK92 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: F08AEFD10A47E05C	FASTA	934	107,499
	10 20 30 40 50 60 MQRYELIRLI GRGGMGEVYL AHDKACSRRV ALKKIREDLS DNPLLRKRFL REAKIAADLI 70 80 90 100 110 120 HPGIVPVYSI CSDGESVYYT MPYIEGFSLK HLLKSVWQKE ILSKELEEKT SVKAFLPIFD 130 140 150 160 170 180 KICATVEYIH SKGVLHRDLK PDNILLGLFG EVVIVDWGAA IFKHAKELQQ EKDEEGFSSY 190 200 210 220 230 240 GQKNICYSSM TVPGKIVGTP DYMAPESLLG AEASEKTDIY ALGLILYQML TLSFPYRRKK 250 260 270 280 290 300 GRKLPYEDSI LSPIEMAPYR EIPPSLSQIA MKAIAVDPVQ RFSSVQELRK ALQPHLQGES 310 320 330 340 350 360 EWTTRDILST KDRKNWKYYE PILLSRYFPV LASSPAQWYN FMLSDMEVNS SVRVECSVTK 370 380 390 400 410 420 SSVQEGVGIF FPPSKEADKG EFYCGYGLWF SSQNNELSVS LIKNGIEIQK ESQGIIPQQS 430 440 450 460 470 480 RFAISIEKSN NKITVFVDQI LFILHIDYLP SLGERIEIII QDLQGISNIT ILESIGALRV 490 500 510 520 530 540 SCLAVPDAFL AEKLYDQAAR FYRKIRDSFP GRKESYEAQF RLGVTLLTQI EEQGGDLMQA 550 560 570 580 590 600 LSTFDLLHGS TGAPLEYLGK ALVYQRNGSF VEEIRSLLLA LKRYPQHPEI PRLKDHLCFR 610 620 630 640 650 660 LYDSLHKHRS EALVFMLLIL WIAPEKIGLR EEERFLEFLH HRQQSTLFCR IDKTPLQFKS 670 680 690 700 710 720 SKMELFLSFW TGFTLFLPEL FQRARDLRDY QALIDIFYVV CASGNKEVFS QFAEDLAIFV 730 740 750 760 770 780 DEVVFPKSLH NQRGEELVLF VQGLAALQNR EYRQAKEFIS AVPFALQLYA LDLFSLQAFI 790 800 810 820 830 840 DEEVKVFSDF LQDIYNSASA EDHKHVLVYM IQVSLWNQDL KQAYELLSKN FPQDKGLIEY 850 860 870 880 890 900 SEAFVLWGCY LALTGDRSAV KAHFSRCQFK YGRSALIGKC IDDDSLDYLE GLVWWEKKKT 910 920 930 LFQSYFLLRC LHAPKERYEV YRQAYISMEN SFFG

References

[1]

"Genome sequences of Chlamydia trachomatis MoPn and Chlamydia pneumoniae AR39." Read T.D., Brunham R.C., Shen C., Gill S.R., Heidelberg J.F., White O., Hickey E.K., Peterson J.D., Utterback T.R., Berry K.J., Bass S., Linher K.D., Weidman J.F., Khouri H.M., Craven B., Bowman C., Dodson R.J., Gwinn M.L. , Nelson W.C., DeBoy R.T., Kolonay J.F., McClarty G., Salzberg S.L., Eisen J.A., Fraser C.M. Nucleic Acids Res. 28:1397-1406(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MoPn / Nigg.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE002160 Genomic DNA. Translation: AAF73573.1.
RefSeq	NP_296951.1. NC_002620.2.
3D structure databases
ProteinModelPortal	Q9PK92.
ModBase	Search...
Protein-protein interaction databases
STRING	243161.TC0575.
Proteomic databases
PRIDE	Q9PK92.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAF73573; AAF73573; TC_0575.
GeneID	1245934.
KEGG	cmu:TC0575.
PATRIC	20372594. VBIChlMur19118_0613.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0515.
KO	K08884.
OMA	YQMLTLS.
ProtClustDB	PRK13184.
Enzyme and pathway databases
BioCyc	CMUR243161:GHYU-595-MONOMER.
Family and domain databases
HAMAP	MF_01957. PknD_kinase.
InterPro	IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR008271. Ser/Thr_kinase_AS. IPR023507. Ser/Thr_kinase_PknD. [Graphical view]
Pfam	PF00069. Pkinase. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
PROSITE	PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PKND_CHLMU

Accession

Primary (citable) accession number: Q9PK92

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 11, 2001
Last sequence update:	October 1, 2000
Last modified:	May 29, 2013
This is version 82 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program