Q9PK62 (DXS_CHLMU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
1-deoxy-D-xylulose-5-phosphate synthase
EC=2.2.1.7

Alternative name(s):
1-deoxyxylulose-5-phosphate synthase
Short name=DXP synthase
Short name=DXPS

Gene names

Name:	dxs
Ordered Locus Names:	TC_0608

Organism

Chlamydia muridarum [Complete proteome] [HAMAP]

Taxonomic identifier

83560 [NCBI]

Taxonomic lineage

Bacteria › Chlamydiae › Chlamydiales › Chlamydiaceae › Chlamydia/Chlamydophila group › Chlamydia

Protein attributes

Sequence length	632 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) By similarity. HAMAP MF_00315
Catalytic activity	Pyruvate + D-glyceraldehyde 3-phosphate = 1-deoxy-D-xylulose 5-phosphate + CO2. HAMAP MF_00315
Cofactor	Binds 1 thiamine pyrophosphate per subunit By similarity.
Pathway	Metabolic intermediate biosynthesis; 1-deoxy-D-xylulose 5-phosphate biosynthesis; 1-deoxy-D-xylulose 5-phosphate from D-glyceraldehyde 3-phosphate and pyruvate: step 1/1. HAMAP MF_00315
Subunit structure	Homodimer By similarity. HAMAP MF_00315
Sequence similarities	Belongs to the transketolase family. DXPS subfamily.

Ontologies

Keywords
Biological process	Isoprene biosynthesis Thiamine biosynthesis
Ligand	Thiamine pyrophosphate
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	terpenoid biosynthetic process Inferred from electronic annotation. Source: InterPro thiamine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	1-deoxy-D-xylulose-5-phosphate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 632	632	1-deoxy-D-xylulose-5-phosphate synthase HAMAP MF_00315		PRO_0000189100

Sequences

	Sequence		Length	Mass (Da)
	Q9PK62 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: 5D66940957C07C47	FASTA	632	69,339
	10 20 30 40 50 60 MISPLLQHIS SPQKLRSLSL DQLPLLCDEI RNRIIATLSL TGGHLASNLG IVELTVALHY 70 80 90 100 110 120 VFASPEDQFI FDVGHQAYVH KLLTGRNTEA FSNIRHDNGL SGFTSPQESN HDIFFSGHAG 130 140 150 160 170 180 NALSLALGLA KGASHGSSHI LPILGDAAFS CGLTLEALNN VPSDLSKFII VLNDNQMSIS 190 200 210 220 230 240 ENVGNIPQGI SQWIQPPKFD KIFQKIHSWM RKIPGFSRQK SELLHKVDIA LKSLSHPLFE 250 260 270 280 290 300 QFGIHYVGPF DGHNIKKLIP ALEAVKGLPY PVLFHVCTAK GNGLAEAEKD PALYHGVKAY 310 320 330 340 350 360 FKNHSPKKKP LSSEVKTPSS FPQHVGHILC QLGEKHPRLQ VVTPAMSLGS CLEDFRKQFP 370 380 390 400 410 420 DRFTDVGIAE GHAVTFSAGI ARSGTPVVCS IYSTFLNRAM DNVFHDVCMQ ELPVIFAIDR 430 440 450 460 470 480 AGLAFHDGRS HHGIYDLGFL CSMPNMVVCQ PRNASVLERL LFSSLLWKSP CAIRYPNLST 490 500 510 520 530 540 RKEVSNPSFS PIFPGEAEVL CQGDDLLLIA LGHMCDTALA VKEQLLDHGI STTVVDPIFI 550 560 570 580 590 600 KPLDTELLQT LLSHHSKVVV LEEHSIHGGL SAEFLLFLNN HNLKTDVLSL GIPDIFIPHG 610 620 630 NPETILNMIG LTSDQITLKI LAHFNFSAPI PI

References

[1]

"Genome sequences of Chlamydia trachomatis MoPn and Chlamydia pneumoniae AR39." Read T.D., Brunham R.C., Shen C., Gill S.R., Heidelberg J.F., White O., Hickey E.K., Peterson J.D., Utterback T.R., Berry K.J., Bass S., Linher K.D., Weidman J.F., Khouri H.M., Craven B., Bowman C., Dodson R.J., Gwinn M.L. , Nelson W.C., DeBoy R.T., Kolonay J.F., McClarty G., Salzberg S.L., Eisen J.A., Fraser C.M. Nucleic Acids Res. 28:1397-1406(2000) [PubMed: 10684935] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MoPn / Nigg.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE002160 Genomic DNA. Translation: AAF39439.1.
PIR	E81684.
RefSeq	NP_296984.1. NC_002620.2.
3D structure databases
ProteinModelPortal	Q9PK62.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1245970.
GenomeReviews	Gene locus TC_0608 in contig AE002160_GR.
KEGG	cmu:TC0608.
PATRIC	20372668. VBIChlMur19118_0647.
TIGR	TC_0608.
Phylogenomic databases
HOGENOM	HBG571647.
OMA	QYDISYM.
ProtClustDB	PRK05444.
Enzyme and pathway databases
BioCyc	CMUR243161:TC_0608-MONOMER.
Family and domain databases
HAMAP	MF_00315. DXP_synth. [Tree]
InterPro	IPR005477. Dxylulose-5-P_synthase. IPR009014. Transketo_C/Pyr-ferredox_oxred. IPR015941. Transketolase-like_C. IPR005475. Transketolase-like_Pyr-bd. IPR005476. Transketolase_C. [Graphical view]
Gene3D	G3DSA:3.40.50.920. Transketo_C_like. 1 hit.
KO	K01662.
Pfam	PF02779. Transket_pyr. 1 hit. PF02780. Transketolase_C. 1 hit. [Graphical view]
SMART	SM00861. Transket_pyr. 1 hit. [Graphical view]
SUPFAM	SSF52922. Transketo_C_like. 1 hit.
TIGRFAMs	TIGR00204. Dxs. 1 hit.
PROSITE	PS00801. TRANSKETOLASE_1. False negative. PS00802. TRANSKETOLASE_2. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DXS_CHLMU

Accession

Primary (citable) accession number: Q9PK62

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 21, 2001
Last sequence update:	October 1, 2000
Last modified:	January 25, 2012
This is version 75 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program