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Q9PK61

- KPYK_CHLMU

UniProt

Q9PK61 - KPYK_CHLMU

Protein

Pyruvate kinase

Gene

pyk

Organism
Chlamydia muridarum (strain MoPn / Nigg)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + pyruvate = ADP + phosphoenolpyruvate.

    Cofactori

    Magnesium.
    Potassium.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei33 – 331SubstrateBy similarity
    Metal bindingi35 – 351PotassiumBy similarity
    Metal bindingi37 – 371PotassiumBy similarity
    Metal bindingi67 – 671PotassiumBy similarity
    Metal bindingi68 – 681Potassium; via carbonyl oxygenBy similarity
    Sitei219 – 2191Transition state stabilizerBy similarity
    Metal bindingi221 – 2211MagnesiumBy similarity
    Binding sitei244 – 2441Substrate; via amide nitrogenBy similarity
    Metal bindingi245 – 2451MagnesiumBy similarity
    Binding sitei245 – 2451Substrate; via amide nitrogenBy similarity
    Binding sitei277 – 2771SubstrateBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. magnesium ion binding Source: InterPro
    3. potassium ion binding Source: InterPro
    4. pyruvate kinase activity Source: UniProtKB-EC

    GO - Biological processi

    1. glycolytic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    ATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Potassium, Pyruvate

    Enzyme and pathway databases

    BioCyciCMUR243161:GHYU-632-MONOMER.
    UniPathwayiUPA00109; UER00188.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pyruvate kinase (EC:2.7.1.40)
    Short name:
    PK
    Gene namesi
    Name:pyk
    Ordered Locus Names:TC_0609
    OrganismiChlamydia muridarum (strain MoPn / Nigg)
    Taxonomic identifieri243161 [NCBI]
    Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
    ProteomesiUP000000800: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 481481Pyruvate kinasePRO_0000112061Add
    BLAST

    Interactioni

    Subunit structurei

    Homotetramer.By similarity

    Protein-protein interaction databases

    STRINGi243161.TC0609.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9PK61.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the pyruvate kinase family.Curated

    Phylogenomic databases

    eggNOGiCOG0469.
    KOiK00873.
    OMAiFIPANSE.
    OrthoDBiEOG6GBMB0.

    Family and domain databases

    Gene3Di2.40.33.10. 1 hit.
    3.20.20.60. 2 hits.
    3.40.1380.20. 1 hit.
    InterProiIPR001697. Pyr_Knase.
    IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
    IPR011037. Pyrv_Knase-like_insert_dom.
    IPR015794. Pyrv_Knase_a/b.
    IPR015793. Pyrv_Knase_brl.
    IPR015795. Pyrv_Knase_C.
    IPR015806. Pyrv_Knase_insert_dom.
    [Graphical view]
    PANTHERiPTHR11817. PTHR11817. 1 hit.
    PfamiPF00224. PK. 1 hit.
    PF02887. PK_C. 1 hit.
    [Graphical view]
    PRINTSiPR01050. PYRUVTKNASE.
    SUPFAMiSSF50800. SSF50800. 1 hit.
    SSF51621. SSF51621. 2 hits.
    SSF52935. SSF52935. 1 hit.
    TIGRFAMsiTIGR01064. pyruv_kin. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9PK61-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIARTKIICT IGPATNTPEM LEKLLDAGMN VARLNFSHGT HESHGRTIAI    50
    LKELREKRQV PLAIMLDTKG PEIRLGQVES PIKVKPGDRL TLTSKEILGS 100
    KEAGVTLYPS CVFPFVRERA PVLIDDGYIQ AVVVNAQEHL IEIEFQNSGE 150
    IKSNKSLSIK DIDVALPFMT EKDITDLKFG VEQELDLIAA SFVRCNEDID 200
    SMRKVLENFG RPNMPIIAKI ENHLGVQNFQ EIAKASDGIM IARGDLGIEL 250
    SIVEVPALQK FMARVSRETG RFCITATQML ESMIRNPLPT RAEVSDVANA 300
    IHDGTSAVML SGETASGTYP IEAVKTMRSI IQETEKSFDY QAFFQLNDKN 350
    SALKVSPYLE AIGASGIQIA EKASAKAIIV YTQTGGSPMF LSKYRPYLPI 400
    IAVTPNRNVY YRLAVEWGVY PMLTSESNRT VWRHQACVYG VEKGILSNYD 450
    KILVFSRGAG MQDTNNLTLT TVNDVLSPSL E 481
    Length:481
    Mass (Da):53,175
    Last modified:October 1, 2000 - v1
    Checksum:i9222E5DAED557B51
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE002160 Genomic DNA. Translation: AAF39440.1.
    PIRiF81684.
    RefSeqiNP_296985.1. NC_002620.2.

    Genome annotation databases

    EnsemblBacteriaiAAF39440; AAF39440; TC_0609.
    GeneIDi1245971.
    KEGGicmu:TC_0609.
    PATRICi20372670. VBIChlMur19118_0648.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE002160 Genomic DNA. Translation: AAF39440.1 .
    PIRi F81684.
    RefSeqi NP_296985.1. NC_002620.2.

    3D structure databases

    ProteinModelPortali Q9PK61.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 243161.TC0609.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAF39440 ; AAF39440 ; TC_0609 .
    GeneIDi 1245971.
    KEGGi cmu:TC_0609.
    PATRICi 20372670. VBIChlMur19118_0648.

    Phylogenomic databases

    eggNOGi COG0469.
    KOi K00873.
    OMAi FIPANSE.
    OrthoDBi EOG6GBMB0.

    Enzyme and pathway databases

    UniPathwayi UPA00109 ; UER00188 .
    BioCyci CMUR243161:GHYU-632-MONOMER.

    Family and domain databases

    Gene3Di 2.40.33.10. 1 hit.
    3.20.20.60. 2 hits.
    3.40.1380.20. 1 hit.
    InterProi IPR001697. Pyr_Knase.
    IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
    IPR011037. Pyrv_Knase-like_insert_dom.
    IPR015794. Pyrv_Knase_a/b.
    IPR015793. Pyrv_Knase_brl.
    IPR015795. Pyrv_Knase_C.
    IPR015806. Pyrv_Knase_insert_dom.
    [Graphical view ]
    PANTHERi PTHR11817. PTHR11817. 1 hit.
    Pfami PF00224. PK. 1 hit.
    PF02887. PK_C. 1 hit.
    [Graphical view ]
    PRINTSi PR01050. PYRUVTKNASE.
    SUPFAMi SSF50800. SSF50800. 1 hit.
    SSF51621. SSF51621. 2 hits.
    SSF52935. SSF52935. 1 hit.
    TIGRFAMsi TIGR01064. pyruv_kin. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MoPn / Nigg.

    Entry informationi

    Entry nameiKPYK_CHLMU
    AccessioniPrimary (citable) accession number: Q9PK61
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 27, 2001
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 91 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3