Pyruvate kinase - Chlamydia muridarum

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Reviewed, UniProtKB/Swiss-Prot Q9PK61 (KPYK_CHLMU)

Last modified June 16, 2009. Version 55. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein names

Recommended name:
    Pyruvate kinase
      Short name=PK
    EC=2.7.1.40

Gene names

Name:	pyk
Ordered Locus Names:	TC_0609

Organism

Chlamydia muridarum [Complete proteome] [HAMAP]

Taxonomic identifier

Taxonomic lineage

Bacteria › Chlamydiae › Chlamydiales › Chlamydiaceae › Chlamydia

Protein attributes

Sequence length	481 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + pyruvate = ADP + phosphoenolpyruvate.
Cofactor	Magnesium. Potassium.
Pathway	Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.
Subunit structure	Homotetramer By similarity.
Sequence similarities	Belongs to the pyruvate kinase family.

Ontologies

Keywords
Biological process	Glycolysis
Ligand	ATP-binding Magnesium Metal-binding Nucleotide-binding Pyruvate
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycolysis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW magnesium ion binding Inferred from electronic annotation. Source: UniProtKB-KW potassium ion binding Inferred from electronic annotation. Source: InterPro pyruvate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

481

Pyruvate kinase

PRO_0000112061

Sites

Active site

1

By similarity

Metal binding

1

Magnesium By similarity

Metal binding

1

Magnesium By similarity

Metal binding

1

Magnesium By similarity

Sequences

Sequence

Length

Mass (Da)

Tools

Q9PK61-1 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: 9222E5DAED557B51
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481

53,175

        10         20         30         40         50         60 
MIARTKIICT IGPATNTPEM LEKLLDAGMN VARLNFSHGT HESHGRTIAI LKELREKRQV 

        70         80         90        100        110        120 
PLAIMLDTKG PEIRLGQVES PIKVKPGDRL TLTSKEILGS KEAGVTLYPS CVFPFVRERA 

       130        140        150        160        170        180 
PVLIDDGYIQ AVVVNAQEHL IEIEFQNSGE IKSNKSLSIK DIDVALPFMT EKDITDLKFG 

       190        200        210        220        230        240 
VEQELDLIAA SFVRCNEDID SMRKVLENFG RPNMPIIAKI ENHLGVQNFQ EIAKASDGIM 

       250        260        270        280        290        300 
IARGDLGIEL SIVEVPALQK FMARVSRETG RFCITATQML ESMIRNPLPT RAEVSDVANA 

       310        320        330        340        350        360 
IHDGTSAVML SGETASGTYP IEAVKTMRSI IQETEKSFDY QAFFQLNDKN SALKVSPYLE 

       370        380        390        400        410        420 
AIGASGIQIA EKASAKAIIV YTQTGGSPMF LSKYRPYLPI IAVTPNRNVY YRLAVEWGVY 

       430        440        450        460        470        480 
PMLTSESNRT VWRHQACVYG VEKGILSNYD KILVFSRGAG MQDTNNLTLT TVNDVLSPSL 


E

References

[1]

"Genome sequences of Chlamydia trachomatis MoPn and Chlamydia pneumoniae AR39."
Read T.D., Brunham R.C., Shen C., Gill S.R., Heidelberg J.F., White O., Hickey E.K., Peterson J.D., Utterback T.R., Berry K.J., Bass S., Linher K.D., Weidman J.F., Khouri H.M., Craven B., Bowman C., Dodson R.J., Gwinn M.L.

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Fraser C.M.
Nucleic Acids Res. 28:1397-1406(2000) [PubMed: 10684935] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: MoPn / Nigg.

Cross-references

Sequence databases
	AE002160 Genomic DNA. Translation: AAF39440.1.
PIR	F81684.
RefSeq	NP_296985.1.
3D structure databases
HSSP	HSSP built from PDB template 1E0T based on UniProtKB P14178.
ModBase	Search...
Genome annotation databases
GeneID	1245971.
GenomeReviews	Gene locus TC_0609 in contig AE002160_GR.
KEGG	cmu:TC0609.
TIGR	TC_0609.
Phylogenomic databases
HOGENOM	Q9PK61.
OMA	Q9PK61. DSECAVK.
Enzyme and pathway databases
BioCyc	CMUR243161:TC_0609-MON.
BRENDA	2.7.1.40. 256349.
Family and domain databases
InterPro	IPR001697. Pyr_Knase. IPR015813. Pyrv/PenolPyrv_Kinase_cat. IPR015794. Pyrv_Knase_a/b. IPR018209. Pyrv_Knase_AS. IPR015793. Pyrv_Knase_brl. [Graphical view]
Gene3D	G3DSA:3.20.20.60. Pyrv/PenolPyrv_Kinase_cat. 1 hit. G3DSA:3.40.1380.20. Pyrv_Knase_a/b. 1 hit.
PANTHER	PTHR11817. Pyruvate_kinase. 1 hit.
Pfam	PF00224. PK. 1 hit. PF02887. PK_C. 1 hit. [Graphical view]
PRINTS	PR01050. PYRUVTKNASE.
ProDom	PD001009. Pyruvate_kinase. 2 hits. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR01064. pyruv_kin. 1 hit.
PROSITE	PS00110. PYRUVATE_KINASE. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KPYK_CHLMU

Accession

Primary (citable) accession number: Q9PK61

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 27, 2001
Last sequence update:	October 1, 2000
Last modified:	June 16, 2009
This is version 55 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents