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Q9PK61 (KPYK_CHLMU) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 88. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Pyruvate kinase

Short name=PK
EC=2.7.1.40
Gene names
Name:pyk
Ordered Locus Names:TC_0609
OrganismChlamydia muridarum (strain MoPn / Nigg) [Complete proteome] [HAMAP]
Taxonomic identifier243161 [NCBI]
Taxonomic lineageBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia

Protein attributes

Sequence length481 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + pyruvate = ADP + phosphoenolpyruvate.

Cofactor

Magnesium.

Potassium.

Pathway

Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.

Subunit structure

Homotetramer By similarity.

Sequence similarities

Belongs to the pyruvate kinase family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 481481Pyruvate kinase
PRO_0000112061

Sites

Metal binding351Potassium By similarity
Metal binding371Potassium By similarity
Metal binding671Potassium By similarity
Metal binding681Potassium; via carbonyl oxygen By similarity
Metal binding2211Magnesium By similarity
Metal binding2451Magnesium By similarity
Binding site331Substrate By similarity
Binding site2441Substrate; via amide nitrogen By similarity
Binding site2451Substrate; via amide nitrogen By similarity
Binding site2771Substrate By similarity
Site2191Transition state stabilizer By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9PK61 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: 9222E5DAED557B51

FASTA48153,175
        10         20         30         40         50         60 
MIARTKIICT IGPATNTPEM LEKLLDAGMN VARLNFSHGT HESHGRTIAI LKELREKRQV 

        70         80         90        100        110        120 
PLAIMLDTKG PEIRLGQVES PIKVKPGDRL TLTSKEILGS KEAGVTLYPS CVFPFVRERA 

       130        140        150        160        170        180 
PVLIDDGYIQ AVVVNAQEHL IEIEFQNSGE IKSNKSLSIK DIDVALPFMT EKDITDLKFG 

       190        200        210        220        230        240 
VEQELDLIAA SFVRCNEDID SMRKVLENFG RPNMPIIAKI ENHLGVQNFQ EIAKASDGIM 

       250        260        270        280        290        300 
IARGDLGIEL SIVEVPALQK FMARVSRETG RFCITATQML ESMIRNPLPT RAEVSDVANA 

       310        320        330        340        350        360 
IHDGTSAVML SGETASGTYP IEAVKTMRSI IQETEKSFDY QAFFQLNDKN SALKVSPYLE 

       370        380        390        400        410        420 
AIGASGIQIA EKASAKAIIV YTQTGGSPMF LSKYRPYLPI IAVTPNRNVY YRLAVEWGVY 

       430        440        450        460        470        480 
PMLTSESNRT VWRHQACVYG VEKGILSNYD KILVFSRGAG MQDTNNLTLT TVNDVLSPSL 


E 

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE002160 Genomic DNA. Translation: AAF39440.1.
PIRF81684.
RefSeqNP_296985.1. NC_002620.2.

3D structure databases

ProteinModelPortalQ9PK61.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING243161.TC0609.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAF39440; AAF39440; TC_0609.
GeneID1245971.
KEGGcmu:TC_0609.
PATRIC20372670. VBIChlMur19118_0648.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0469.
KOK00873.
OMANNKGVNF.
OrthoDBEOG6GBMB0.
ProtClustDBPRK05826.

Enzyme and pathway databases

BioCycCMUR243161:GHYU-632-MONOMER.
UniPathwayUPA00109; UER00188.

Family and domain databases

Gene3D2.40.33.10. 1 hit.
3.20.20.60. 2 hits.
3.40.1380.20. 1 hit.
InterProIPR001697. Pyr_Knase.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
IPR011037. Pyrv_Knase-like_insert_dom.
IPR015794. Pyrv_Knase_a/b.
IPR015793. Pyrv_Knase_brl.
IPR015795. Pyrv_Knase_C.
IPR015806. Pyrv_Knase_insert_dom.
[Graphical view]
PANTHERPTHR11817. PTHR11817. 1 hit.
PfamPF00224. PK. 1 hit.
PF02887. PK_C. 1 hit.
[Graphical view]
PRINTSPR01050. PYRUVTKNASE.
SUPFAMSSF50800. SSF50800. 1 hit.
SSF51621. SSF51621. 2 hits.
SSF52935. SSF52935. 1 hit.
TIGRFAMsTIGR01064. pyruv_kin. 1 hit.
ProtoNetSearch...

Entry information

Entry nameKPYK_CHLMU
AccessionPrimary (citable) accession number: Q9PK61
Entry history
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: October 1, 2000
Last modified: February 19, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways