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Q9PK61

- KPYK_CHLMU

UniProt

Q9PK61 - KPYK_CHLMU

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Protein

Pyruvate kinase

Gene
pyk, TC_0609
Organism
Chlamydia muridarum (strain MoPn / Nigg)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + pyruvate = ADP + phosphoenolpyruvate.

Cofactori

Magnesium.
Potassium.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei33 – 331Substrate By similarity
Metal bindingi35 – 351Potassium By similarity
Metal bindingi37 – 371Potassium By similarity
Metal bindingi67 – 671Potassium By similarity
Metal bindingi68 – 681Potassium; via carbonyl oxygen By similarity
Sitei219 – 2191Transition state stabilizer By similarity
Metal bindingi221 – 2211Magnesium By similarity
Binding sitei244 – 2441Substrate; via amide nitrogen By similarity
Metal bindingi245 – 2451Magnesium By similarity
Binding sitei245 – 2451Substrate; via amide nitrogen By similarity
Binding sitei277 – 2771Substrate By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. magnesium ion binding Source: InterPro
  3. potassium ion binding Source: InterPro
  4. pyruvate kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. glycolytic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Potassium, Pyruvate

Enzyme and pathway databases

BioCyciCMUR243161:GHYU-632-MONOMER.
UniPathwayiUPA00109; UER00188.

Names & Taxonomyi

Protein namesi
Recommended name:
Pyruvate kinase (EC:2.7.1.40)
Short name:
PK
Gene namesi
Name:pyk
Ordered Locus Names:TC_0609
OrganismiChlamydia muridarum (strain MoPn / Nigg)
Taxonomic identifieri243161 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
ProteomesiUP000000800: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 481481Pyruvate kinasePRO_0000112061Add
BLAST

Interactioni

Subunit structurei

Homotetramer By similarity.

Protein-protein interaction databases

STRINGi243161.TC0609.

Structurei

3D structure databases

ProteinModelPortaliQ9PK61.

Family & Domainsi

Sequence similaritiesi

Belongs to the pyruvate kinase family.

Phylogenomic databases

eggNOGiCOG0469.
KOiK00873.
OMAiFIPANSE.
OrthoDBiEOG6GBMB0.

Family and domain databases

Gene3Di2.40.33.10. 1 hit.
3.20.20.60. 2 hits.
3.40.1380.20. 1 hit.
InterProiIPR001697. Pyr_Knase.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
IPR011037. Pyrv_Knase-like_insert_dom.
IPR015794. Pyrv_Knase_a/b.
IPR015793. Pyrv_Knase_brl.
IPR015795. Pyrv_Knase_C.
IPR015806. Pyrv_Knase_insert_dom.
[Graphical view]
PANTHERiPTHR11817. PTHR11817. 1 hit.
PfamiPF00224. PK. 1 hit.
PF02887. PK_C. 1 hit.
[Graphical view]
PRINTSiPR01050. PYRUVTKNASE.
SUPFAMiSSF50800. SSF50800. 1 hit.
SSF51621. SSF51621. 2 hits.
SSF52935. SSF52935. 1 hit.
TIGRFAMsiTIGR01064. pyruv_kin. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9PK61-1 [UniParc]FASTAAdd to Basket

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MIARTKIICT IGPATNTPEM LEKLLDAGMN VARLNFSHGT HESHGRTIAI    50
LKELREKRQV PLAIMLDTKG PEIRLGQVES PIKVKPGDRL TLTSKEILGS 100
KEAGVTLYPS CVFPFVRERA PVLIDDGYIQ AVVVNAQEHL IEIEFQNSGE 150
IKSNKSLSIK DIDVALPFMT EKDITDLKFG VEQELDLIAA SFVRCNEDID 200
SMRKVLENFG RPNMPIIAKI ENHLGVQNFQ EIAKASDGIM IARGDLGIEL 250
SIVEVPALQK FMARVSRETG RFCITATQML ESMIRNPLPT RAEVSDVANA 300
IHDGTSAVML SGETASGTYP IEAVKTMRSI IQETEKSFDY QAFFQLNDKN 350
SALKVSPYLE AIGASGIQIA EKASAKAIIV YTQTGGSPMF LSKYRPYLPI 400
IAVTPNRNVY YRLAVEWGVY PMLTSESNRT VWRHQACVYG VEKGILSNYD 450
KILVFSRGAG MQDTNNLTLT TVNDVLSPSL E 481
Length:481
Mass (Da):53,175
Last modified:October 1, 2000 - v1
Checksum:i9222E5DAED557B51
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE002160 Genomic DNA. Translation: AAF39440.1.
PIRiF81684.
RefSeqiNP_296985.1. NC_002620.2.

Genome annotation databases

EnsemblBacteriaiAAF39440; AAF39440; TC_0609.
GeneIDi1245971.
KEGGicmu:TC_0609.
PATRICi20372670. VBIChlMur19118_0648.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE002160 Genomic DNA. Translation: AAF39440.1 .
PIRi F81684.
RefSeqi NP_296985.1. NC_002620.2.

3D structure databases

ProteinModelPortali Q9PK61.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243161.TC0609.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAF39440 ; AAF39440 ; TC_0609 .
GeneIDi 1245971.
KEGGi cmu:TC_0609.
PATRICi 20372670. VBIChlMur19118_0648.

Phylogenomic databases

eggNOGi COG0469.
KOi K00873.
OMAi FIPANSE.
OrthoDBi EOG6GBMB0.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00188 .
BioCyci CMUR243161:GHYU-632-MONOMER.

Family and domain databases

Gene3Di 2.40.33.10. 1 hit.
3.20.20.60. 2 hits.
3.40.1380.20. 1 hit.
InterProi IPR001697. Pyr_Knase.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
IPR011037. Pyrv_Knase-like_insert_dom.
IPR015794. Pyrv_Knase_a/b.
IPR015793. Pyrv_Knase_brl.
IPR015795. Pyrv_Knase_C.
IPR015806. Pyrv_Knase_insert_dom.
[Graphical view ]
PANTHERi PTHR11817. PTHR11817. 1 hit.
Pfami PF00224. PK. 1 hit.
PF02887. PK_C. 1 hit.
[Graphical view ]
PRINTSi PR01050. PYRUVTKNASE.
SUPFAMi SSF50800. SSF50800. 1 hit.
SSF51621. SSF51621. 2 hits.
SSF52935. SSF52935. 1 hit.
TIGRFAMsi TIGR01064. pyruv_kin. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MoPn / Nigg.

Entry informationi

Entry nameiKPYK_CHLMU
AccessioniPrimary (citable) accession number: Q9PK61
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: October 1, 2000
Last modified: June 11, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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