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Q9PK41

- DEF_CHLMU

UniProt

Q9PK41 - DEF_CHLMU

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Protein

Peptide deformylase

Gene

def

Organism
Chlamydia muridarum (strain MoPn / Nigg)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity).By similarity

Catalytic activityi

Formyl-L-methionyl peptide + H2O = formate + methionyl peptide.

Cofactori

Binds 1 Fe2+ ion.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi99 – 991IronBy similarity
Metal bindingi141 – 1411IronBy similarity
Active sitei142 – 1421By similarity
Metal bindingi145 – 1451IronBy similarity

GO - Molecular functioni

  1. iron ion binding Source: InterPro
  2. peptide deformylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. translation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

BioCyciCMUR243161:GHYU-654-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Peptide deformylase (EC:3.5.1.88)
Short name:
PDF
Alternative name(s):
Polypeptide deformylase
Gene namesi
Name:def
Ordered Locus Names:TC_0632
OrganismiChlamydia muridarum (strain MoPn / Nigg)
Taxonomic identifieri243161 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
ProteomesiUP000000800: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 181181Peptide deformylasePRO_0000082761Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi243161.TC0632.

Structurei

3D structure databases

ProteinModelPortaliQ9PK41.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the polypeptide deformylase family.Curated

Phylogenomic databases

eggNOGiCOG0242.
KOiK01462.
OMAiFPARIVM.
OrthoDBiEOG664CMF.

Family and domain databases

Gene3Di3.90.45.10. 1 hit.
HAMAPiMF_00163. Pep_deformylase.
InterProiIPR000181. Fmet_deformylase.
IPR023635. Peptide_deformylase.
[Graphical view]
PANTHERiPTHR10458. PTHR10458. 1 hit.
PfamiPF01327. Pep_deformylase. 1 hit.
[Graphical view]
PIRSFiPIRSF004749. Pep_def. 1 hit.
PRINTSiPR01576. PDEFORMYLASE.
SUPFAMiSSF56420. SSF56420. 1 hit.
TIGRFAMsiTIGR00079. pept_deformyl. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9PK41-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIRDLEYYDS PILRKVAAPI DEITDELRQL VLDMSETMTF YKGVGLAAPQ
60 70 80 90 100
VGHSVALFIM GVEKELDDGE LIFCDFPKVF INPVITQKSE QLVYGNEGCL
110 120 130 140 150
SIPGLRGEVA RPDKITVTAK NLDGQPFSMT LEGFLARIVM HETDHLHGVL
160 170 180
YIDRMSDKDK TKQFKNNLEK IRRKYSILRG L
Length:181
Mass (Da):20,535
Last modified:October 1, 2000 - v1
Checksum:i5EB21D7C0A3995CA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE002160 Genomic DNA. Translation: AAF39461.1.
PIRiC81680.
RefSeqiNP_297006.1. NC_002620.2.

Genome annotation databases

EnsemblBacteriaiAAF39461; AAF39461; TC_0632.
GeneIDi1245992.
KEGGicmu:TC_0632.
PATRICi20372716. VBIChlMur19118_0671.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE002160 Genomic DNA. Translation: AAF39461.1 .
PIRi C81680.
RefSeqi NP_297006.1. NC_002620.2.

3D structure databases

ProteinModelPortali Q9PK41.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243161.TC0632.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAF39461 ; AAF39461 ; TC_0632 .
GeneIDi 1245992.
KEGGi cmu:TC_0632.
PATRICi 20372716. VBIChlMur19118_0671.

Phylogenomic databases

eggNOGi COG0242.
KOi K01462.
OMAi FPARIVM.
OrthoDBi EOG664CMF.

Enzyme and pathway databases

BioCyci CMUR243161:GHYU-654-MONOMER.

Family and domain databases

Gene3Di 3.90.45.10. 1 hit.
HAMAPi MF_00163. Pep_deformylase.
InterProi IPR000181. Fmet_deformylase.
IPR023635. Peptide_deformylase.
[Graphical view ]
PANTHERi PTHR10458. PTHR10458. 1 hit.
Pfami PF01327. Pep_deformylase. 1 hit.
[Graphical view ]
PIRSFi PIRSF004749. Pep_def. 1 hit.
PRINTSi PR01576. PDEFORMYLASE.
SUPFAMi SSF56420. SSF56420. 1 hit.
TIGRFAMsi TIGR00079. pept_deformyl. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MoPn / Nigg.

Entry informationi

Entry nameiDEF_CHLMU
AccessioniPrimary (citable) accession number: Q9PK41
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: October 1, 2000
Last modified: October 1, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3