Reviewed,
UniProtKB/Swiss-Prot Q9PK33 (DAPA_CHLMU)
Last modified
November 3, 2009.
Version 55.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Dihydrodipicolinate synthase Short name=DHDPS EC=4.2.1.52 | ||||
| Gene names |
| ||||
| Organism | Chlamydia muridarum [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 83560 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Chlamydiae › Chlamydiales › Chlamydiaceae › Chlamydia |
Protein attributes
| Sequence length | 286 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Catalytic activity | L-aspartate 4-semialdehyde + pyruvate = dihydrodipicolinate + 2 H2O. HAMAP MF_00418 |
| Pathway | Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 3/4. HAMAP MF_00418 |
| Subunit structure | Homotetramer By similarity. |
| Subcellular location | Cytoplasm By similarity. |
| Sequence similarities | Belongs to the DHDPS family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Amino-acid biosynthesis Diaminopimelate biosynthesis Lysine biosynthesis |
| Cellular component | Cytoplasm |
| Ligand | Schiff base |
| Molecular function | Lyase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | diaminopimelate biosynthetic process Inferred from electronic annotation. Source: HAMAP |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | dihydrodipicolinate synthase activity Inferred from electronic annotation. Source: HAMAP |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 286 | 286 | Dihydrodipicolinate synthase HAMAP MF_00418 | PRO_0000103099 | |||||
Sites | |||||||||
| Active site | 157 | 1 | Schiff-base intermediate with substrate By similarity | ||||||
| Site | 129 | 1 | Involved in proton transfer during cleavage By similarity | ||||||
Sequences
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References
| [1] | "Genome sequences of Chlamydia trachomatis MoPn and Chlamydia pneumoniae AR39." Read T.D., Brunham R.C., Shen C., Gill S.R., Heidelberg J.F., White O., Hickey E.K., Peterson J.D., Utterback T.R., Berry K.J., Bass S., Linher K.D., Weidman J.F., Khouri H.M., Craven B., Bowman C., Dodson R.J., Gwinn M.L. Fraser C.M.Nucleic Acids Res. 28:1397-1406(2000) [PubMed: 10684935] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MoPn / Nigg. |
Cross-references
Sequence databases | |
|---|---|
| AE002160 Genomic DNA. Translation: AAF39469.1. | |
| PIR | C81681. |
| RefSeq | NP_297014.1. |
3D structure databases | |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 1246001. |
| GenomeReviews | Gene locus TC_0640 in contig AE002160_GR. |
| KEGG | cmu:TC0640. |
| TIGR | TC_0640. |
Phylogenomic databases | |
| HOGENOM | Q9PK33. |
| OMA | ALCAMIT. |
Enzyme and pathway databases | |
| BioCyc | CMUR243161:TC_0640-MON. |
| BRENDA | 4.2.1.52. 256349. |
Family and domain databases | |
| HAMAP | MF_00418. [Tree] |
| InterPro | IPR013785. Aldolase_TIM. IPR005263. DapA_synth. IPR002220. DHDPS. [Graphical view] |
| Gene3D | G3DSA:3.20.20.70. Aldolase_TIM. 1 hit. |
| PANTHER | PTHR12128. DHDPS. 1 hit. |
| Pfam | PF00701. DHDPS. 1 hit. [Graphical view] |
| PRINTS | PR00146. DHPICSNTHASE. |
| ProDom | PD001859. DHDPS. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| TIGRFAMs | TIGR00674. dapA. 1 hit. |
| PROSITE | PS00665. DHDPS_1. 1 hit. PS00666. DHDPS_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | DAPA_CHLMU | ||||||||
| Accession | Primary (citable) accession number: Q9PK33 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


