Reviewed, UniProtKB/Swiss-Prot Q9PK32 (AK_CHLMU)

Names and origin

Protein names

Recommended name:
    Aspartokinase
    EC=2.7.2.4
Alternative name(s):
    Aspartate kinase

Gene names

Name:	lysC
Ordered Locus Names:	TC_0641

Organism

Chlamydia muridarum [Complete proteome] [HAMAP]

Taxonomic identifier

83560 [NCBI]

Taxonomic lineage

Bacteria › Chlamydiae › Chlamydiales › Chlamydiaceae › Chlamydia

Protein attributes

Sequence length	437 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + L-aspartate = ADP + 4-phospho-L-aspartate.
Pathway	Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; tetrahydrodipicolinate from L-aspartate: step 1/4. Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 1/3. Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 1/5.
Sequence similarities	Belongs to the aspartokinase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Diaminopimelate biosynthesis Lysine biosynthesis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	diaminopimelate biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW aspartate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 437	437	Aspartokinase		PRO_0000066673

Sequences

	Sequence		Length	Mass (Da)
	Q9PK32-1 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: 3E74D659E04906FA	FASTA	437	47,795
	10 20 30 40 50 60 MFKEKKAPLV CKFGGTSVGT SSSIQRVCEI IRKEKPSFVV VSAVAGVTDL LEEFCRAPVG 70 80 90 100 110 120 QKSQFTAMIR EKHESIAKEL GIDVAIEPFL GPLKQFEGAG HLQQEDQAKI LAIGEDLSAS 130 140 150 160 170 180 LICSYCRANS LQLEQLEARQ VILTDSQFLR AEPDLALMQT MWGELVLKEN TIYLMQGFLG 190 200 210 220 230 240 ATASGATTVL GRGGSDFSAS LVGELCEARE LRIYTDVRGV HTADPKILKD TQLIDFLTFE 250 260 270 280 290 300 EMQELASSGS KVLHQDMLKP CIRAKVPIFV TSTFDLTKEG TWICASLNEG VEGPEIKALS 310 320 330 340 350 360 LKANQALWFV EYHSPLMRLE NVLRCVRGLG SIPGVVMAQN SGVYFTVDWE ENNQSMTEAL 370 380 390 400 410 420 REFGAVSCEG PVSLVALVGA KLTSWSMTGV FDALQGTPVL YWSQTDTVIN LIINEESGVV 430 VTKLLHDYVL GLNRSGL

References

[1]

"Genome sequences of Chlamydia trachomatis MoPn and Chlamydia pneumoniae AR39." Read T.D., Brunham R.C., Shen C., Gill S.R., Heidelberg J.F., White O., Hickey E.K., Peterson J.D., Utterback T.R., Berry K.J., Bass S., Linher K.D., Weidman J.F., Khouri H.M., Craven B., Bowman C., Dodson R.J., Gwinn M.L. , Nelson W.C., DeBoy R.T., Kolonay J.F., McClarty G., Salzberg S.L., Eisen J.A., Fraser C.M. Nucleic Acids Res. 28:1397-1406(2000) [PubMed: 10684935] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MoPn / Nigg.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE002160 Genomic DNA. Translation: AAF39470.1.
PIR	D81681.
RefSeq	NP_297015.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1246002.
GenomeReviews	Gene locus TC_0641 in contig AE002160_GR.
KEGG	cmu:TC0641.
TIGR	TC_0641.
Phylogenomic databases
HOGENOM	Q9PK32.
OMA	Q9PK32. DESEAAN.
Enzyme and pathway databases
BioCyc	CMUR243161:TC_0641-MON.
BRENDA	2.7.2.4. 256349.
Family and domain databases
InterPro	IPR001048. Asp/Glu/Uridylate_kinase. IPR001341. Asp_kin_reg. IPR018042. Aspartate_kinase_CS. [Graphical view]
Gene3D	G3DSA:3.40.1160.10. Aa_kinase. 1 hit.
Pfam	PF00696. AA_kinase. 1 hit. [Graphical view]
TIGRFAMs	TIGR00657. asp_kinases. 1 hit.
PROSITE	PS00324. ASPARTOKINASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AK_CHLMU

Accession

Primary (citable) accession number: Q9PK32

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 2001
Last sequence update:	October 1, 2000
Last modified:	June 16, 2009
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)