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Q9PK21

- AAXB_CHLMU

UniProt

Q9PK21 - AAXB_CHLMU

Protein

Pyruvoyl-dependent arginine decarboxylase AaxB

Gene

aaxB

Organism
Chlamydia muridarum (strain MoPn / Nigg)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 66 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Part of the AaxABC system, catalyzes the decarboxylation of L-arginine. The arginine uptake by the bacterium in the macrophage may be a virulence factor against the host innate immune response By similarity.By similarity

    Catalytic activityi

    L-arginine = agmatine + CO2.

    Cofactori

    Pyruvoyl group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei52 – 532Cleavage (non-hydrolytic)By similarity

    GO - Molecular functioni

    1. arginine decarboxylase activity Source: UniProtKB-EC

    GO - Biological processi

    1. arginine catabolic process Source: InterPro
    2. pathogenesis Source: UniProtKB-KW

    Keywords - Molecular functioni

    Decarboxylase, Lyase

    Keywords - Biological processi

    Virulence

    Keywords - Ligandi

    Pyruvate

    Enzyme and pathway databases

    BioCyciCMUR243161:GHYU-675-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pyruvoyl-dependent arginine decarboxylase AaxB (EC:4.1.1.19)
    Short name:
    PvlArgDC
    Alternative name(s):
    Biodegradative arginine decarboxylase
    Cleaved into the following 2 chains:
    Gene namesi
    Name:aaxB
    Ordered Locus Names:TC_0652
    OrganismiChlamydia muridarum (strain MoPn / Nigg)
    Taxonomic identifieri243161 [NCBI]
    Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
    ProteomesiUP000000800: Chromosome

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 5252Pyruvoyl-dependent arginine decarboxylase subunit betaPRO_0000364045Add
    BLAST
    Chaini53 – 195143Pyruvoyl-dependent arginine decarboxylase subunit alphaPRO_0000364046Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei53 – 531Pyruvic acid (Ser)By similarity

    Interactioni

    Subunit structurei

    Trimer of an alpha-beta dimer.By similarity

    Protein-protein interaction databases

    STRINGi243161.TC0652.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9PK21.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG1945.
    OMAiWAVEYVE.
    OrthoDBiEOG6Q5NT3.

    Family and domain databases

    Gene3Di3.50.20.10. 1 hit.
    InterProiIPR016104. Pyr-dep_his/arg-deCO2ase.
    IPR016105. Pyr-dep_his/arg-deCO2ase_sand.
    IPR002724. Pyruvoyl-dep_arg_deCO2ase.
    [Graphical view]
    PfamiPF01862. PvlArgDC. 1 hit.
    [Graphical view]
    ProDomiPD010449. Pyruvoyl-dep_arg_deCO2ase. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SUPFAMiSSF56271. SSF56271. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9PK21-1 [UniParc]FASTAAdd to Basket

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    MPYGTRYPTL AFHTGGVGES DDGMPPQPFE TFCYDSALLQ AKIENFNIVP    50
    YTSVLPKELF GNILPVDQCT KFFKHGAVLE VIMAGKGAAV AEGTQAIATG 100
    VGICWGKDKN GDLIGGWAAE YVEFFPTWID DEIAESHAKM WLKKSLQHEL 150
    DLRSVSKHSE FQYFHNYINI KKKFGFCLTA LGFLNFENAD PVVIQ 195
    Length:195
    Mass (Da):21,707
    Last modified:October 1, 2000 - v1
    Checksum:i865D6DAED68C1463
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE002160 Genomic DNA. Translation: AAF39478.1.
    PIRiB81680.
    RefSeqiNP_297026.1. NC_002620.2.

    Genome annotation databases

    EnsemblBacteriaiAAF39478; AAF39478; TC_0652.
    GeneIDi1246013.
    KEGGicmu:TC_0652.
    PATRICi20372758. VBIChlMur19118_0691.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE002160 Genomic DNA. Translation: AAF39478.1 .
    PIRi B81680.
    RefSeqi NP_297026.1. NC_002620.2.

    3D structure databases

    ProteinModelPortali Q9PK21.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 243161.TC0652.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAF39478 ; AAF39478 ; TC_0652 .
    GeneIDi 1246013.
    KEGGi cmu:TC_0652.
    PATRICi 20372758. VBIChlMur19118_0691.

    Phylogenomic databases

    eggNOGi COG1945.
    OMAi WAVEYVE.
    OrthoDBi EOG6Q5NT3.

    Enzyme and pathway databases

    BioCyci CMUR243161:GHYU-675-MONOMER.

    Family and domain databases

    Gene3Di 3.50.20.10. 1 hit.
    InterProi IPR016104. Pyr-dep_his/arg-deCO2ase.
    IPR016105. Pyr-dep_his/arg-deCO2ase_sand.
    IPR002724. Pyruvoyl-dep_arg_deCO2ase.
    [Graphical view ]
    Pfami PF01862. PvlArgDC. 1 hit.
    [Graphical view ]
    ProDomi PD010449. Pyruvoyl-dep_arg_deCO2ase. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SUPFAMi SSF56271. SSF56271. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MoPn / Nigg.

    Entry informationi

    Entry nameiAAXB_CHLMU
    AccessioniPrimary (citable) accession number: Q9PK21
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 10, 2009
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 66 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3