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Q9PJY4

- LPXB_CHLMU

UniProt

Q9PJY4 - LPXB_CHLMU

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Protein

Lipid-A-disaccharide synthase

Gene

lpxB

Organism
Chlamydia muridarum (strain MoPn / Nigg)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.By similarity

Catalytic activityi

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.

Pathwayi

GO - Molecular functioni

  1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid A biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciCMUR243161:GHYU-715-MONOMER.
UniPathwayiUPA00359; UER00481.

Protein family/group databases

CAZyiGT19. Glycosyltransferase Family 19.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid-A-disaccharide synthase (EC:2.4.1.182)
Gene namesi
Name:lpxB
Ordered Locus Names:TC_0692
OrganismiChlamydia muridarum (strain MoPn / Nigg)
Taxonomic identifieri243161 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
ProteomesiUP000000800: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 607607Lipid-A-disaccharide synthasePRO_0000190159Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi243161.TC0692.

Structurei

3D structure databases

ProteinModelPortaliQ9PJY4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 224224UnknownAdd
BLAST
Regioni225 – 607383Lipid-A-disaccharide synthaseAdd
BLAST

Sequence similaritiesi

In the C-terminal section; belongs to the LpxB family.Curated

Phylogenomic databases

eggNOGiCOG3952.
KOiK00748.
OMAiKIIHYVC.
OrthoDBiEOG6FBWZR.

Family and domain databases

HAMAPiMF_00392. LpxB.
InterProiIPR003835. Glyco_trans_19.
IPR011499. Lipid_A_biosynth.
[Graphical view]
PfamiPF07578. LAB_N. 2 hits.
PF02684. LpxB. 1 hit.
[Graphical view]
ProDomiPD339292. LAB_N. 2 hits.
[Graphical view] [Entries sharing at least one domain]
TIGRFAMsiTIGR00215. lpxB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9PJY4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFPQKITLWL YPLGLFANLF FGTAFCVQWF LIKKRGCSFV PKIFWHLSCS
60 70 80 90 100
GAVLMICHGF IQSQYPIALL HSFNLIIYFR NLNIASSTPL PISKIVSLLV
110 120 130 140 150
VSATAITLSF AIGTQYLPHM TWMASPNILH LNLPEANFLW QLIGCIGLTI
160 170 180 190 200
FSLRFFIQWF YLEYKNQSSL PTPFWKASLV GGSICLIYFL RTGDIVNVLC
210 220 230 240 250
YGCGLFPSLA NLRIASREAI QKPFSCSCFI SAGEHSGDTL GGNLLKEIHA
260 270 280 290 300
KYPDIHCFGV GGPQMRAQNF CTLFSMEKFQ ISGFWEVLLA LPKLWYRRRI
310 320 330 340 350
LYKTILKRNP QAVICIDFPD FHFLLIKKLR SLGYKGKIVH YVCPSIWAWR
360 370 380 390 400
PSRKTTLEKY LDLLLLILPF EQKLFKDSPL RTVYIGHPLS ETIKLFCPKQ
410 420 430 440 450
NWKERLHLPT DKPFVAAFPG SRHSDILRNL TIQVQAFQAS DFASTHHLLV
460 470 480 490 500
SSANPAYDHL ILEILQQNRC LHSNIVPSQF RYELMRECDC ALAKCGTIVL
510 520 530 540 550
ETALNLTPTI VTCQLRPLDT FLAKYIFNII LPAYSLPNII LGRTIFPEFI
560 570 580 590 600
GGKKDFRYED VAAALNILKT SQAQEKQKNA CKDVYQAINE SASTIKECLP

FIFEASY
Length:607
Mass (Da):69,198
Last modified:October 1, 2000 - v1
Checksum:iF794FD9B10FBB259
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE002160 Genomic DNA. Translation: AAF39508.1.
PIRiE81676.
RefSeqiNP_297066.1. NC_002620.2.

Genome annotation databases

EnsemblBacteriaiAAF39508; AAF39508; TC_0692.
GeneIDi1246053.
KEGGicmu:TC_0692.
PATRICi20372840. VBIChlMur19118_0732.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE002160 Genomic DNA. Translation: AAF39508.1 .
PIRi E81676.
RefSeqi NP_297066.1. NC_002620.2.

3D structure databases

ProteinModelPortali Q9PJY4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243161.TC0692.

Protein family/group databases

CAZyi GT19. Glycosyltransferase Family 19.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAF39508 ; AAF39508 ; TC_0692 .
GeneIDi 1246053.
KEGGi cmu:TC_0692.
PATRICi 20372840. VBIChlMur19118_0732.

Phylogenomic databases

eggNOGi COG3952.
KOi K00748.
OMAi KIIHYVC.
OrthoDBi EOG6FBWZR.

Enzyme and pathway databases

UniPathwayi UPA00359 ; UER00481 .
BioCyci CMUR243161:GHYU-715-MONOMER.

Family and domain databases

HAMAPi MF_00392. LpxB.
InterProi IPR003835. Glyco_trans_19.
IPR011499. Lipid_A_biosynth.
[Graphical view ]
Pfami PF07578. LAB_N. 2 hits.
PF02684. LpxB. 1 hit.
[Graphical view ]
ProDomi PD339292. LAB_N. 2 hits.
[Graphical view ] [Entries sharing at least one domain ]
TIGRFAMsi TIGR00215. lpxB. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MoPn / Nigg.

Entry informationi

Entry nameiLPXB_CHLMU
AccessioniPrimary (citable) accession number: Q9PJY4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: October 1, 2000
Last modified: October 1, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3