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Q9PJY4

- LPXB_CHLMU

UniProt

Q9PJY4 - LPXB_CHLMU

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Protein
Lipid-A-disaccharide synthase
Gene
lpxB, TC_0692
Organism
Chlamydia muridarum (strain MoPn / Nigg)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity.UniRule annotation

Catalytic activityi

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid A biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciCMUR243161:GHYU-715-MONOMER.
UniPathwayiUPA00359; UER00481.

Protein family/group databases

CAZyiGT19. Glycosyltransferase Family 19.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid-A-disaccharide synthase (EC:2.4.1.182)
Gene namesi
Name:lpxB
Ordered Locus Names:TC_0692
OrganismiChlamydia muridarum (strain MoPn / Nigg)
Taxonomic identifieri243161 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
ProteomesiUP000000800: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 607607Lipid-A-disaccharide synthaseUniRule annotation
PRO_0000190159Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi243161.TC0692.

Structurei

3D structure databases

ProteinModelPortaliQ9PJY4.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 224224UnknownUniRule annotation
Add
BLAST
Regioni225 – 607383Lipid-A-disaccharide synthaseUniRule annotation
Add
BLAST

Sequence similaritiesi

In the C-terminal section; belongs to the LpxB family.

Phylogenomic databases

eggNOGiCOG3952.
KOiK00748.
OMAiKIIHYVC.
OrthoDBiEOG6FBWZR.

Family and domain databases

HAMAPiMF_00392. LpxB.
InterProiIPR003835. Glyco_trans_19.
IPR011499. Lipid_A_biosynth.
[Graphical view]
PfamiPF07578. LAB_N. 2 hits.
PF02684. LpxB. 1 hit.
[Graphical view]
ProDomiPD339292. LAB_N. 2 hits.
[Graphical view] [Entries sharing at least one domain]
TIGRFAMsiTIGR00215. lpxB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9PJY4-1 [UniParc]FASTAAdd to Basket

« Hide

MFPQKITLWL YPLGLFANLF FGTAFCVQWF LIKKRGCSFV PKIFWHLSCS    50
GAVLMICHGF IQSQYPIALL HSFNLIIYFR NLNIASSTPL PISKIVSLLV 100
VSATAITLSF AIGTQYLPHM TWMASPNILH LNLPEANFLW QLIGCIGLTI 150
FSLRFFIQWF YLEYKNQSSL PTPFWKASLV GGSICLIYFL RTGDIVNVLC 200
YGCGLFPSLA NLRIASREAI QKPFSCSCFI SAGEHSGDTL GGNLLKEIHA 250
KYPDIHCFGV GGPQMRAQNF CTLFSMEKFQ ISGFWEVLLA LPKLWYRRRI 300
LYKTILKRNP QAVICIDFPD FHFLLIKKLR SLGYKGKIVH YVCPSIWAWR 350
PSRKTTLEKY LDLLLLILPF EQKLFKDSPL RTVYIGHPLS ETIKLFCPKQ 400
NWKERLHLPT DKPFVAAFPG SRHSDILRNL TIQVQAFQAS DFASTHHLLV 450
SSANPAYDHL ILEILQQNRC LHSNIVPSQF RYELMRECDC ALAKCGTIVL 500
ETALNLTPTI VTCQLRPLDT FLAKYIFNII LPAYSLPNII LGRTIFPEFI 550
GGKKDFRYED VAAALNILKT SQAQEKQKNA CKDVYQAINE SASTIKECLP 600
FIFEASY 607
Length:607
Mass (Da):69,198
Last modified:October 1, 2000 - v1
Checksum:iF794FD9B10FBB259
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE002160 Genomic DNA. Translation: AAF39508.1.
PIRiE81676.
RefSeqiNP_297066.1. NC_002620.2.

Genome annotation databases

EnsemblBacteriaiAAF39508; AAF39508; TC_0692.
GeneIDi1246053.
KEGGicmu:TC_0692.
PATRICi20372840. VBIChlMur19118_0732.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE002160 Genomic DNA. Translation: AAF39508.1 .
PIRi E81676.
RefSeqi NP_297066.1. NC_002620.2.

3D structure databases

ProteinModelPortali Q9PJY4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243161.TC0692.

Protein family/group databases

CAZyi GT19. Glycosyltransferase Family 19.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAF39508 ; AAF39508 ; TC_0692 .
GeneIDi 1246053.
KEGGi cmu:TC_0692.
PATRICi 20372840. VBIChlMur19118_0732.

Phylogenomic databases

eggNOGi COG3952.
KOi K00748.
OMAi KIIHYVC.
OrthoDBi EOG6FBWZR.

Enzyme and pathway databases

UniPathwayi UPA00359 ; UER00481 .
BioCyci CMUR243161:GHYU-715-MONOMER.

Family and domain databases

HAMAPi MF_00392. LpxB.
InterProi IPR003835. Glyco_trans_19.
IPR011499. Lipid_A_biosynth.
[Graphical view ]
Pfami PF07578. LAB_N. 2 hits.
PF02684. LpxB. 1 hit.
[Graphical view ]
ProDomi PD339292. LAB_N. 2 hits.
[Graphical view ] [Entries sharing at least one domain ]
TIGRFAMsi TIGR00215. lpxB. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MoPn / Nigg.

Entry informationi

Entry nameiLPXB_CHLMU
AccessioniPrimary (citable) accession number: Q9PJY4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: October 1, 2000
Last modified: May 14, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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