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Q9PJY4

- LPXB_CHLMU

UniProt

Q9PJY4 - LPXB_CHLMU

Protein

Lipid-A-disaccharide synthase

Gene

lpxB

Organism
Chlamydia muridarum (strain MoPn / Nigg)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.By similarity

    Catalytic activityi

    UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.

    Pathwayi

    GO - Molecular functioni

    1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. lipid A biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

    Enzyme and pathway databases

    BioCyciCMUR243161:GHYU-715-MONOMER.
    UniPathwayiUPA00359; UER00481.

    Protein family/group databases

    CAZyiGT19. Glycosyltransferase Family 19.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lipid-A-disaccharide synthase (EC:2.4.1.182)
    Gene namesi
    Name:lpxB
    Ordered Locus Names:TC_0692
    OrganismiChlamydia muridarum (strain MoPn / Nigg)
    Taxonomic identifieri243161 [NCBI]
    Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
    ProteomesiUP000000800: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 607607Lipid-A-disaccharide synthasePRO_0000190159Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi243161.TC0692.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9PJY4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 224224UnknownAdd
    BLAST
    Regioni225 – 607383Lipid-A-disaccharide synthaseAdd
    BLAST

    Sequence similaritiesi

    In the C-terminal section; belongs to the LpxB family.Curated

    Phylogenomic databases

    eggNOGiCOG3952.
    KOiK00748.
    OMAiKIIHYVC.
    OrthoDBiEOG6FBWZR.

    Family and domain databases

    HAMAPiMF_00392. LpxB.
    InterProiIPR003835. Glyco_trans_19.
    IPR011499. Lipid_A_biosynth.
    [Graphical view]
    PfamiPF07578. LAB_N. 2 hits.
    PF02684. LpxB. 1 hit.
    [Graphical view]
    ProDomiPD339292. LAB_N. 2 hits.
    [Graphical view] [Entries sharing at least one domain]
    TIGRFAMsiTIGR00215. lpxB. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9PJY4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFPQKITLWL YPLGLFANLF FGTAFCVQWF LIKKRGCSFV PKIFWHLSCS    50
    GAVLMICHGF IQSQYPIALL HSFNLIIYFR NLNIASSTPL PISKIVSLLV 100
    VSATAITLSF AIGTQYLPHM TWMASPNILH LNLPEANFLW QLIGCIGLTI 150
    FSLRFFIQWF YLEYKNQSSL PTPFWKASLV GGSICLIYFL RTGDIVNVLC 200
    YGCGLFPSLA NLRIASREAI QKPFSCSCFI SAGEHSGDTL GGNLLKEIHA 250
    KYPDIHCFGV GGPQMRAQNF CTLFSMEKFQ ISGFWEVLLA LPKLWYRRRI 300
    LYKTILKRNP QAVICIDFPD FHFLLIKKLR SLGYKGKIVH YVCPSIWAWR 350
    PSRKTTLEKY LDLLLLILPF EQKLFKDSPL RTVYIGHPLS ETIKLFCPKQ 400
    NWKERLHLPT DKPFVAAFPG SRHSDILRNL TIQVQAFQAS DFASTHHLLV 450
    SSANPAYDHL ILEILQQNRC LHSNIVPSQF RYELMRECDC ALAKCGTIVL 500
    ETALNLTPTI VTCQLRPLDT FLAKYIFNII LPAYSLPNII LGRTIFPEFI 550
    GGKKDFRYED VAAALNILKT SQAQEKQKNA CKDVYQAINE SASTIKECLP 600
    FIFEASY 607
    Length:607
    Mass (Da):69,198
    Last modified:October 1, 2000 - v1
    Checksum:iF794FD9B10FBB259
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE002160 Genomic DNA. Translation: AAF39508.1.
    PIRiE81676.
    RefSeqiNP_297066.1. NC_002620.2.

    Genome annotation databases

    EnsemblBacteriaiAAF39508; AAF39508; TC_0692.
    GeneIDi1246053.
    KEGGicmu:TC_0692.
    PATRICi20372840. VBIChlMur19118_0732.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE002160 Genomic DNA. Translation: AAF39508.1 .
    PIRi E81676.
    RefSeqi NP_297066.1. NC_002620.2.

    3D structure databases

    ProteinModelPortali Q9PJY4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 243161.TC0692.

    Protein family/group databases

    CAZyi GT19. Glycosyltransferase Family 19.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAF39508 ; AAF39508 ; TC_0692 .
    GeneIDi 1246053.
    KEGGi cmu:TC_0692.
    PATRICi 20372840. VBIChlMur19118_0732.

    Phylogenomic databases

    eggNOGi COG3952.
    KOi K00748.
    OMAi KIIHYVC.
    OrthoDBi EOG6FBWZR.

    Enzyme and pathway databases

    UniPathwayi UPA00359 ; UER00481 .
    BioCyci CMUR243161:GHYU-715-MONOMER.

    Family and domain databases

    HAMAPi MF_00392. LpxB.
    InterProi IPR003835. Glyco_trans_19.
    IPR011499. Lipid_A_biosynth.
    [Graphical view ]
    Pfami PF07578. LAB_N. 2 hits.
    PF02684. LpxB. 1 hit.
    [Graphical view ]
    ProDomi PD339292. LAB_N. 2 hits.
    [Graphical view ] [Entries sharing at least one domain ]
    TIGRFAMsi TIGR00215. lpxB. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MoPn / Nigg.

    Entry informationi

    Entry nameiLPXB_CHLMU
    AccessioniPrimary (citable) accession number: Q9PJY4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 2001
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 80 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3