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Q9PJW2

- DAPF_CHLMU

UniProt

Q9PJW2 - DAPF_CHLMU

Protein

Diaminopimelate epimerase

Gene

dapF

Organism
Chlamydia muridarum (strain MoPn / Nigg)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 83 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.UniRule annotation

    Catalytic activityi

    LL-2,6-diaminoheptanedioate = meso-diaminoheptanedioate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei20 – 201SubstrateUniRule annotation
    Binding sitei45 – 451SubstrateUniRule annotation
    Binding sitei63 – 631SubstrateUniRule annotation
    Active sitei72 – 721Proton donor/acceptorUniRule annotation
    Sitei147 – 1471Important for catalytic activityUniRule annotation
    Binding sitei179 – 1791SubstrateUniRule annotation
    Sitei197 – 1971Important for catalytic activityUniRule annotation
    Active sitei207 – 2071Proton donor/acceptorUniRule annotation

    GO - Molecular functioni

    1. diaminopimelate epimerase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. lysine biosynthetic process via diaminopimelate Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Amino-acid biosynthesis, Lysine biosynthesis

    Enzyme and pathway databases

    BioCyciCMUR243161:GHYU-739-MONOMER.
    UniPathwayiUPA00034; UER00025.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Diaminopimelate epimeraseUniRule annotation (EC:5.1.1.7UniRule annotation)
    Short name:
    DAP epimeraseUniRule annotation
    Gene namesi
    Name:dapFUniRule annotation
    Ordered Locus Names:TC_0714
    OrganismiChlamydia muridarum (strain MoPn / Nigg)
    Taxonomic identifieri243161 [NCBI]
    Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
    ProteomesiUP000000800: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 269269Diaminopimelate epimerasePRO_0000149830Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi72 ↔ 207

    Keywords - PTMi

    Disulfide bond

    Interactioni

    Protein-protein interaction databases

    STRINGi243161.TC0714.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9PJW2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni72 – 743Substrate bindingUniRule annotation
    Regioni197 – 1982Substrate bindingUniRule annotation
    Regioni208 – 2092Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the diaminopimelate epimerase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0253.
    KOiK01778.
    OMAiNGLRCVI.
    OrthoDBiEOG6ND0M5.

    Family and domain databases

    HAMAPiMF_00197. DAP_epimerase.
    InterProiIPR018510. DAP_epimerase_AS.
    IPR001653. DAP_epimerase_DapF.
    [Graphical view]
    PANTHERiPTHR31689. PTHR31689. 1 hit.
    PfamiPF01678. DAP_epimerase. 2 hits.
    [Graphical view]
    TIGRFAMsiTIGR00652. DapF. 1 hit.
    PROSITEiPS01326. DAP_EPIMERASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9PJW2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGSFSPLMTY RYHLYSGTGN SFILGEFIPP LQHIVFLCQK EKVDGFLCVE    50
    PSEIADAKLT IFNSDGSEAS MCGNGLRCVM AHVAQSLGLE DVSIETVRGV 100
    YQGKFFSMDR VLVDMTLLDW KKTKKTLTHV LPGMPEEVFF IDTGVPHVVV 150
    FVPDVNKVPV QEWGAFLRYH EDFRPNGVNV DFVQTKKEDT LLVYTYERGC 200
    ERETLSCGTG MLASALVAAD VFSLEQDFSL LVCSRSGNIV KIFSENGKVF 250
    LEGPVTLLNC SENIGEFAP 269
    Length:269
    Mass (Da):29,864
    Last modified:October 1, 2000 - v1
    Checksum:iECDE5D168060E1C2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE002160 Genomic DNA. Translation: AAF73596.1.
    RefSeqiNP_297088.1. NC_002620.2.
    WP_010231302.1. NZ_ACOV01000003.1.

    Genome annotation databases

    EnsemblBacteriaiAAF73596; AAF73596; TC_0714.
    GeneIDi1246077.
    KEGGicmu:TC_0714.
    PATRICi20372894. VBIChlMur19118_0757.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE002160 Genomic DNA. Translation: AAF73596.1 .
    RefSeqi NP_297088.1. NC_002620.2.
    WP_010231302.1. NZ_ACOV01000003.1.

    3D structure databases

    ProteinModelPortali Q9PJW2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 243161.TC0714.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAF73596 ; AAF73596 ; TC_0714 .
    GeneIDi 1246077.
    KEGGi cmu:TC_0714.
    PATRICi 20372894. VBIChlMur19118_0757.

    Phylogenomic databases

    eggNOGi COG0253.
    KOi K01778.
    OMAi NGLRCVI.
    OrthoDBi EOG6ND0M5.

    Enzyme and pathway databases

    UniPathwayi UPA00034 ; UER00025 .
    BioCyci CMUR243161:GHYU-739-MONOMER.

    Family and domain databases

    HAMAPi MF_00197. DAP_epimerase.
    InterProi IPR018510. DAP_epimerase_AS.
    IPR001653. DAP_epimerase_DapF.
    [Graphical view ]
    PANTHERi PTHR31689. PTHR31689. 1 hit.
    Pfami PF01678. DAP_epimerase. 2 hits.
    [Graphical view ]
    TIGRFAMsi TIGR00652. DapF. 1 hit.
    PROSITEi PS01326. DAP_EPIMERASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MoPn / Nigg.

    Entry informationi

    Entry nameiDAPF_CHLMU
    AccessioniPrimary (citable) accession number: Q9PJW2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 27, 2001
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 83 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3