Reviewed, UniProtKB/Swiss-Prot Q9PJU1 (CDSA_CHLMU)

Names and origin

Protein names

Recommended name:
    Phosphatidate cytidylyltransferase
    EC=2.7.7.41
Alternative name(s):
    CDP-diglyceride pyrophosphorylase
    CDP-diglyceride synthase
    CDP-diacylglycerol synthase
      Short name=CDS
    CTP:phosphatidate cytidylyltransferase
    CDP-DG synthase
    CDP-DAG synthase

Gene names

Name:	cdsA
Ordered Locus Names:	TC_0736

Organism

Chlamydia muridarum [Complete proteome] [HAMAP]

Taxonomic identifier

83560 [NCBI]

Taxonomic lineage

Bacteria › Chlamydiae › Chlamydiales › Chlamydiaceae › Chlamydia

Protein attributes

Sequence length	305 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	CTP + phosphatidate = diphosphate + CDP-diacylglycerol.
Pathway	Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.
Subcellular location	Cell membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the CDS family.

Ontologies

Keywords
Biological process	Phospholipid biosynthesis
Cellular component	Cell membrane Membrane
Domain	Transmembrane
Molecular function	Nucleotidyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	phospholipid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	phosphatidate cytidylyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 305	305	Phosphatidate cytidylyltransferase		PRO_0000090731
Regions
	Transmembrane	24 – 44	21	Potential
	Transmembrane	97 – 117	21	Potential
	Transmembrane	124 – 144	21	Potential
	Transmembrane	151 – 171	21	Potential
	Transmembrane	202 – 222	21	Potential
	Transmembrane	232 – 252	21	Potential
	Transmembrane	277 – 297	21	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q9PJU1-1 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: B5D9F38B0C477EF0	FASTA	305	33,817
	10 20 30 40 50 60 MFDSDKNSIL QSDFCQRLVV HSLLLVFLVI LLCTSLYPSS AFIVGLLSST CAAIGTYEMS 70 80 90 100 110 120 SMVRMKFPFS FTRYSSIGSA IFVALTCLTA RCKMLLPEHV DLIPWFFLFF WTVHLVFKSR 130 140 150 160 170 180 HYKLGPIGST GLALFCMLYV SVPIRLFLHI LYGFVHTDTP FIGIWWAIFL IATTKSSDIF 190 200 210 220 230 240 GYFFGKAFGK KRIAPVISPN KTVVGFVAGC IASILVSLIF YSHLPKSFAN QIAMPWILVA 250 260 270 280 290 300 LGIILGISGF FGDIIESTFK RDAQIKNSSD LESIGGMLDV LDSLLLSTPI VYAILLITQN GTFLG

References

[1]

"Genome sequences of Chlamydia trachomatis MoPn and Chlamydia pneumoniae AR39." Read T.D., Brunham R.C., Shen C., Gill S.R., Heidelberg J.F., White O., Hickey E.K., Peterson J.D., Utterback T.R., Berry K.J., Bass S., Linher K.D., Weidman J.F., Khouri H.M., Craven B., Bowman C., Dodson R.J., Gwinn M.L. , Nelson W.C., DeBoy R.T., Kolonay J.F., McClarty G., Salzberg S.L., Eisen J.A., Fraser C.M. Nucleic Acids Res. 28:1397-1406(2000) [PubMed: 10684935] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MoPn / Nigg.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE002160 Genomic DNA. Translation: AAF39546.1.
PIR	D81670.
RefSeq	NP_297110.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1246099.
GenomeReviews	Gene locus TC_0736 in contig AE002160_GR.
KEGG	cmu:TC0736.
TIGR	TC_0736.
Phylogenomic databases
HOGENOM	HBG414084.
OMA	LYVSVPI.
PhylomeDB	Q9PJU1.
Enzyme and pathway databases
BioCyc	CMUR243161:TC_0736-MONOMER.
BRENDA	2.7.7.41. 256349.
Family and domain databases
InterPro	IPR000374. PC_trans. [Graphical view]
Pfam	PF01148. CTP_transf_1. 1 hit. [Graphical view]
PROSITE	PS01315. CDS. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CDSA_CHLMU

Accession

Primary (citable) accession number: Q9PJU1

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 27, 2001
Last sequence update:	October 1, 2000
Last modified:	February 9, 2010
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)