Reviewed, UniProtKB/Swiss-Prot Q9PJQ6 (HEMH_CHLMU)

Names and origin

Protein names

Recommended name:
    Ferrochelatase
    EC=4.99.1.1
Alternative name(s):
    Protoheme ferro-lyase
    Heme synthetase

Gene names

Name:	hemH
Ordered Locus Names:	TC_0772

Organism

Chlamydia muridarum [Complete proteome] [HAMAP]

Taxonomic identifier

83560 [NCBI]

Taxonomic lineage

Bacteria › Chlamydiae › Chlamydiales › Chlamydiaceae › Chlamydia

Protein attributes

Sequence length	317 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the ferrous insertion into protoporphyrin IX. HAMAP MF_00323
Catalytic activity	Protoheme + 2 H+ = protoporphyrin + Fe2+. HAMAP MF_00323
Pathway	Porphyrin metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1. HAMAP MF_00323
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the ferrochelatase family.

Ontologies

Keywords
Biological process	Heme biosynthesis Porphyrin biosynthesis
Cellular component	Cytoplasm
Ligand	Iron Metal-binding
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	heme biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ferrochelatase activity Inferred from electronic annotation. Source: HAMAP iron ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 317	317	Ferrochelatase HAMAP MF_00323		PRO_0000175128
Sites
	Metal binding	184	1	Iron By similarity
	Metal binding	259	1	Iron By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9PJQ6-1 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: D1030AC8C466896D	FASTA	317	36,090
	10 20 30 40 50 60 MTVYLLANFG GPRISQEIPS FLHALLTDQD VTGGRIPPWL HRPLFSYIAK RRAHRVAEQY 70 80 90 100 110 120 AYLGGRSPIF QDTEKLAQNL SQELQAPVIS FHRYLTETHQ DTLAALRESA GDIIGIPLFP 130 140 150 160 170 180 HYTFAVTGSI IRFFLERIPE KPMAWITHFG VHPQFISCMR EHIQDCLIAQ GIVAEDCFFL 190 200 210 220 230 240 FSVHGLPMRH IRLGDPYAKQ CQDSFNALIG ESEGVLSFQS KFGIGEWLVP STKEICQSLC 250 260 270 280 290 300 TKKRYIVVVP FGFVSDHIET LYEIDHLYVP MLLQRGYRVV RVPAINTSDR WVSALASIVK 310 SSPHETILEP LLMPKRR

References

[1]

"Genome sequences of Chlamydia trachomatis MoPn and Chlamydia pneumoniae AR39." Read T.D., Brunham R.C., Shen C., Gill S.R., Heidelberg J.F., White O., Hickey E.K., Peterson J.D., Utterback T.R., Berry K.J., Bass S., Linher K.D., Weidman J.F., Khouri H.M., Craven B., Bowman C., Dodson R.J., Gwinn M.L. , Nelson W.C., DeBoy R.T., Kolonay J.F., McClarty G., Salzberg S.L., Eisen J.A., Fraser C.M. Nucleic Acids Res. 28:1397-1406(2000) [PubMed: 10684935] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MoPn / Nigg.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE002160 Genomic DNA. Translation: AAF39575.1.
PIR	B81667.
RefSeq	NP_297145.1.
3D structure databases
HSSP	HSSP built from PDB template 1HRK based on UniProtKB P22830.
ModBase	Search...
Genome annotation databases
GeneID	1246137.
GenomeReviews	Gene locus TC_0772 in contig AE002160_GR.
KEGG	cmu:TC0772.
TIGR	TC_0772.
Phylogenomic databases
HOGENOM	Q9PJQ6.
OMA	DEDIERY.
Enzyme and pathway databases
BioCyc	CMUR243161:TC_0772-MON.
BRENDA	4.99.1.1. 256349.
Family and domain databases
HAMAP	MF_00323. [Tree]
InterPro	IPR001015. Ferrochelatase. IPR019772. Ferrochelatase_AS. [Graphical view]
PANTHER	PTHR11108. Ferrochelatase. 1 hit.
Pfam	PF00762. Ferrochelatase. 1 hit. [Graphical view]
ProDom	PD002792. Ferrochelatase. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00109. hemH. 1 hit.
PROSITE	PS00534. FERROCHELATASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HEMH_CHLMU

Accession

Primary (citable) accession number: Q9PJQ6

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 21, 2001
Last sequence update:	October 1, 2000
Last modified:	November 3, 2009
This is version 55 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)