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Q9PJN9 (RUVC_CHLMU) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Crossover junction endodeoxyribonuclease RuvC

EC=3.1.22.4
Alternative name(s):
Holliday junction nuclease RuvC
Holliday junction resolvase RuvC
Gene names
Name:ruvC
Ordered Locus Names:TC_0789
OrganismChlamydia muridarum (strain MoPn / Nigg) [Complete proteome] [HAMAP]
Taxonomic identifier243161 [NCBI]
Taxonomic lineageBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia

Protein attributes

Sequence length170 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group By similarity. HAMAP-Rule MF_00034

Catalytic activity

Endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction). HAMAP-Rule MF_00034

Cofactor

Binds 1 magnesium ion per subunit By similarity. HAMAP-Rule MF_00034

Sequence similarities

Belongs to the RuvC family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 170170Crossover junction endodeoxyribonuclease RuvC HAMAP-Rule MF_00034
PRO_0000183087

Sites

Metal binding91Magnesium By similarity
Metal binding701Magnesium By similarity
Metal binding1451Magnesium By similarity
Metal binding1481Magnesium By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9PJN9 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: F5C349798BEDFD71

FASTA17018,837
        10         20         30         40         50         60 
MADLIMGIDP GTLVCGYAFI RVENRYQIQP HSFGKIKLSQ KQALSHRYRQ LFTEISTILQ 

        70         80         90        100        110        120 
REAPKAVVLE TQYVHKNPQS TIKLGMARGV LLLAASLQDI SVFEYAPNTA KKAAVGKGNA 

       130        140        150        160        170 
SKQQVQLMVS KLLNIQDLLA DDNEDIADAF ALAMCHAHLA PYQDLKKSLL 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE002160 Genomic DNA. Translation: AAF39592.1.
PIRE81662.
RefSeqNP_297162.1. NC_002620.2.

3D structure databases

ProteinModelPortalQ9PJN9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING243161.TC0789.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAF39592; AAF39592; TC_0789.
GeneID1246155.
KEGGcmu:TC_0789.
PATRIC20373082. VBIChlMur19118_0847.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0817.
KOK01159.
OMAYTALQMK.
OrthoDBEOG6RG044.
ProtClustDBPRK00039.

Enzyme and pathway databases

BioCycCMUR243161:GHYU-817-MONOMER.

Family and domain databases

Gene3D3.30.420.10. 1 hit.
HAMAPMF_00034. RuvC.
InterProIPR012337. RNaseH-like_dom.
IPR020563. X-over_junc_endoDNase_Mg_BS.
IPR002176. X-over_junc_endoDNase_RuvC.
[Graphical view]
PfamPF02075. RuvC. 1 hit.
[Graphical view]
PRINTSPR00696. RSOLVASERUVC.
SUPFAMSSF53098. SSF53098. 1 hit.
TIGRFAMsTIGR00228. ruvC. 1 hit.
PROSITEPS01321. RUVC. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameRUVC_CHLMU
AccessionPrimary (citable) accession number: Q9PJN9
Entry history
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: October 1, 2000
Last modified: April 16, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families