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Q9PJN9

- RUVC_CHLMU

UniProt

Q9PJN9 - RUVC_CHLMU

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Protein

Crossover junction endodeoxyribonuclease RuvC

Gene

ruvC

Organism
Chlamydia muridarum (strain MoPn / Nigg)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity).By similarity

Catalytic activityi

Endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction).

Cofactori

Binds 1 magnesium ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi9 – 91MagnesiumBy similarity
Metal bindingi70 – 701MagnesiumBy similarity
Metal bindingi145 – 1451MagnesiumBy similarity
Metal bindingi148 – 1481MagnesiumBy similarity

GO - Molecular functioni

  1. crossover junction endodeoxyribonuclease activity Source: UniProtKB-HAMAP
  2. magnesium ion binding Source: UniProtKB-HAMAP
  3. nucleic acid binding Source: InterPro

GO - Biological processi

  1. DNA recombination Source: UniProtKB-HAMAP
  2. DNA repair Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Nuclease

Keywords - Biological processi

DNA damage, DNA recombination, DNA repair

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciCMUR243161:GHYU-817-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Crossover junction endodeoxyribonuclease RuvC (EC:3.1.22.4)
Alternative name(s):
Holliday junction nuclease RuvC
Holliday junction resolvase RuvC
Gene namesi
Name:ruvC
Ordered Locus Names:TC_0789
OrganismiChlamydia muridarum (strain MoPn / Nigg)
Taxonomic identifieri243161 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
ProteomesiUP000000800: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 170170Crossover junction endodeoxyribonuclease RuvCPRO_0000183087Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi243161.TC0789.

Structurei

3D structure databases

ProteinModelPortaliQ9PJN9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RuvC family.Curated

Phylogenomic databases

eggNOGiCOG0817.
KOiK01159.
OMAiYHPDEMA.
OrthoDBiEOG6RG044.

Family and domain databases

Gene3Di3.30.420.10. 1 hit.
HAMAPiMF_00034. RuvC.
InterProiIPR012337. RNaseH-like_dom.
IPR020563. X-over_junc_endoDNase_Mg_BS.
IPR002176. X-over_junc_endoDNase_RuvC.
[Graphical view]
PfamiPF02075. RuvC. 1 hit.
[Graphical view]
PRINTSiPR00696. RSOLVASERUVC.
SUPFAMiSSF53098. SSF53098. 1 hit.
TIGRFAMsiTIGR00228. ruvC. 1 hit.
PROSITEiPS01321. RUVC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9PJN9 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MADLIMGIDP GTLVCGYAFI RVENRYQIQP HSFGKIKLSQ KQALSHRYRQ
60 70 80 90 100
LFTEISTILQ REAPKAVVLE TQYVHKNPQS TIKLGMARGV LLLAASLQDI
110 120 130 140 150
SVFEYAPNTA KKAAVGKGNA SKQQVQLMVS KLLNIQDLLA DDNEDIADAF
160 170
ALAMCHAHLA PYQDLKKSLL
Length:170
Mass (Da):18,837
Last modified:October 1, 2000 - v1
Checksum:iF5C349798BEDFD71
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE002160 Genomic DNA. Translation: AAF39592.1.
PIRiE81662.
RefSeqiNP_297162.1. NC_002620.2.

Genome annotation databases

EnsemblBacteriaiAAF39592; AAF39592; TC_0789.
GeneIDi1246155.
KEGGicmu:TC_0789.
PATRICi20373082. VBIChlMur19118_0847.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE002160 Genomic DNA. Translation: AAF39592.1 .
PIRi E81662.
RefSeqi NP_297162.1. NC_002620.2.

3D structure databases

ProteinModelPortali Q9PJN9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243161.TC0789.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAF39592 ; AAF39592 ; TC_0789 .
GeneIDi 1246155.
KEGGi cmu:TC_0789.
PATRICi 20373082. VBIChlMur19118_0847.

Phylogenomic databases

eggNOGi COG0817.
KOi K01159.
OMAi YHPDEMA.
OrthoDBi EOG6RG044.

Enzyme and pathway databases

BioCyci CMUR243161:GHYU-817-MONOMER.

Family and domain databases

Gene3Di 3.30.420.10. 1 hit.
HAMAPi MF_00034. RuvC.
InterProi IPR012337. RNaseH-like_dom.
IPR020563. X-over_junc_endoDNase_Mg_BS.
IPR002176. X-over_junc_endoDNase_RuvC.
[Graphical view ]
Pfami PF02075. RuvC. 1 hit.
[Graphical view ]
PRINTSi PR00696. RSOLVASERUVC.
SUPFAMi SSF53098. SSF53098. 1 hit.
TIGRFAMsi TIGR00228. ruvC. 1 hit.
PROSITEi PS01321. RUVC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MoPn / Nigg.

Entry informationi

Entry nameiRUVC_CHLMU
AccessioniPrimary (citable) accession number: Q9PJN9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: October 1, 2000
Last modified: October 1, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3