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Protein

Tryptophan--tRNA ligase

Gene

trpS

Organism
Chlamydia muridarum (strain MoPn / Nigg)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the attachment of tryptophan to tRNA(Trp).UniRule annotation

Catalytic activityi

ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei143L-tryptophanUniRule annotation1
Binding sitei193ATP; via amide nitrogen and carbonyl oxygenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi11 – 13ATPUniRule annotation3
Nucleotide bindingi19 – 20ATPUniRule annotation2
Nucleotide bindingi155 – 157ATPUniRule annotation3
Nucleotide bindingi201 – 205ATPUniRule annotation5

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan--tRNA ligaseUniRule annotation (EC:6.1.1.2UniRule annotation)
Alternative name(s):
Tryptophanyl-tRNA synthetaseUniRule annotation
Short name:
TrpRSUniRule annotation
Gene namesi
Name:trpSUniRule annotation
Ordered Locus Names:TC_0874
OrganismiChlamydia muridarum (strain MoPn / Nigg)
Taxonomic identifieri243161 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
Proteomesi
  • UP000000800 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001366181 – 346Tryptophan--tRNA ligaseAdd BLAST346

Proteomic databases

PRIDEiQ9PJF5

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi243161.CmurN_010100004503

Structurei

3D structure databases

ProteinModelPortaliQ9PJF5
SMRiQ9PJF5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi12 – 20"HIGH" regionUniRule annotation9
Motifi201 – 205"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C31 Bacteria
COG0180 LUCA
KOiK01867
OMAiQRMTQFK

Family and domain databases

CDDicd00806 TrpRS_core, 1 hit
Gene3Di3.40.50.620, 2 hits
HAMAPiMF_00140_B Trp_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR002305 aa-tRNA-synth_Ic
IPR014729 Rossmann-like_a/b/a_fold
IPR002306 Trp-tRNA-ligase
IPR024109 Trp-tRNA-ligase_bac-type
PfamiView protein in Pfam
PF00579 tRNA-synt_1b, 1 hit
PRINTSiPR01039 TRNASYNTHTRP
TIGRFAMsiTIGR00233 trpS, 1 hit

Sequencei

Sequence statusi: Complete.

Q9PJF5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKKRVLTGD RPTGKLHLGH WIGSIMNRLQ LQNDPRYDCF FIIADLHTLT
60 70 80 90 100
TKTRKEEVLH IDSHIYDVLA DWLSVGIDPE KSAIYLQSAI PEIYELNLLF
110 120 130 140 150
SMLTPLNHIM GIPSIKEMAR NASINEESLS HGLIGYPVLQ SADILLAKAH
160 170 180 190 200
LVPVGKDNEA HVELTRDIAK TFNRLYGSVF PEPDILQGEL TSLVGTNGQG
210 220 230 240 250
KMSKSANNAI YLSDDEKTVQ EKIRKMYTDP NRVHATTPGR VEGNPLFIYH
260 270 280 290 300
DLFNPHKEEV EEFKTRYRQG CIKDVEVKAR LAEEINLFLN PFREKRSEFV
310 320 330 340
AQPKILEEAL QKGTEKMRSV ARETMEEVHN NLGLSRKWRS ILASSK
Length:346
Mass (Da):39,412
Last modified:October 1, 2000 - v1
Checksum:i2EE5FAAFD0BDB95B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE002160 Genomic DNA Translation: AAF39670.1
PIRiC81654
RefSeqiWP_010231815.1, NZ_ACOV01000004.1

Genome annotation databases

EnsemblBacteriaiAAF39670; AAF39670; TC_0874
GeneIDi1246242
KEGGicmu:TC_0874

Similar proteinsi

Entry informationi

Entry nameiSYW_CHLMU
AccessioniPrimary (citable) accession number: Q9PJF5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: October 1, 2000
Last modified: May 23, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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