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Q9PJF5 (SYW_CHLMU) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tryptophan--tRNA ligase

EC=6.1.1.2
Alternative name(s):
Tryptophanyl-tRNA synthetase
Short name=TrpRS
Gene names
Name:trpS
Ordered Locus Names:TC_0874
OrganismChlamydia muridarum (strain MoPn / Nigg) [Complete proteome] [HAMAP]
Taxonomic identifier243161 [NCBI]
Taxonomic lineageBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia

Protein attributes

Sequence length346 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp). HAMAP-Rule MF_00140_B

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00140_B

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00140_B.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processtryptophanyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

tryptophan-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 346346Tryptophan--tRNA ligase HAMAP-Rule MF_00140_B
PRO_0000136618

Regions

Motif12 – 209"HIGH" region HAMAP-Rule MF_00140_B
Motif201 – 2055"KMSKS" region HAMAP-Rule MF_00140_B

Sites

Binding site2041ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9PJF5 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: 2EE5FAAFD0BDB95B

FASTA34639,412
        10         20         30         40         50         60 
MNKKRVLTGD RPTGKLHLGH WIGSIMNRLQ LQNDPRYDCF FIIADLHTLT TKTRKEEVLH 

        70         80         90        100        110        120 
IDSHIYDVLA DWLSVGIDPE KSAIYLQSAI PEIYELNLLF SMLTPLNHIM GIPSIKEMAR 

       130        140        150        160        170        180 
NASINEESLS HGLIGYPVLQ SADILLAKAH LVPVGKDNEA HVELTRDIAK TFNRLYGSVF 

       190        200        210        220        230        240 
PEPDILQGEL TSLVGTNGQG KMSKSANNAI YLSDDEKTVQ EKIRKMYTDP NRVHATTPGR 

       250        260        270        280        290        300 
VEGNPLFIYH DLFNPHKEEV EEFKTRYRQG CIKDVEVKAR LAEEINLFLN PFREKRSEFV 

       310        320        330        340 
AQPKILEEAL QKGTEKMRSV ARETMEEVHN NLGLSRKWRS ILASSK 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE002160 Genomic DNA. Translation: AAF39670.1.
PIRC81654.
RefSeqNP_297247.1. NC_002620.2.

3D structure databases

ProteinModelPortalQ9PJF5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING243161.TC0874.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAF39670; AAF39670; TC_0874.
GeneID1246242.
KEGGcmu:TC_0874.
PATRIC20373264. VBIChlMur19118_0936.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0180.
KOK01867.
OMAGENFFPI.
OrthoDBEOG686NJQ.

Enzyme and pathway databases

BioCycCMUR243161:GHYU-904-MONOMER.

Family and domain databases

Gene3D3.40.50.620. 1 hit.
HAMAPMF_00140_B. Trp_tRNA_synth_B.
InterProIPR002305. aa-tRNA-synth_Ic.
IPR014729. Rossmann-like_a/b/a_fold.
IPR002306. Trp-tRNA-ligase.
IPR024109. Trp-tRNA-ligase_bac-type.
[Graphical view]
PANTHERPTHR10055. PTHR10055. 1 hit.
PfamPF00579. tRNA-synt_1b. 1 hit.
[Graphical view]
PRINTSPR01039. TRNASYNTHTRP.
TIGRFAMsTIGR00233. trpS. 1 hit.
ProtoNetSearch...

Entry information

Entry nameSYW_CHLMU
AccessionPrimary (citable) accession number: Q9PJF5
Entry history
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: October 1, 2000
Last modified: May 14, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries