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Q9PJF4

- UVRB_CHLMU

UniProt

Q9PJF4 - UVRB_CHLMU

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Protein

UvrABC system protein B

Gene
uvrB, TC_0875
Organism
Chlamydia muridarum (strain MoPn / Nigg)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA2B2 complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage By similarity.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi52 – 598ATP Reviewed prediction

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. DNA binding Source: UniProtKB-HAMAP
  3. excinuclease ABC activity Source: UniProtKB-HAMAP
  4. helicase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. nucleotide-excision repair Source: UniProtKB-HAMAP
  2. SOS response Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Excision nuclease

Keywords - Biological processi

DNA damage, DNA excision, DNA repair, SOS response

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCMUR243161:GHYU-905-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
UvrABC system protein B
Short name:
Protein UvrB
Alternative name(s):
Excinuclease ABC subunit B
Gene namesi
Name:uvrB
Ordered Locus Names:TC_0875
OrganismiChlamydia muridarum (strain MoPn / Nigg)
Taxonomic identifieri243161 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
ProteomesiUP000000800: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 676676UvrABC system protein BUniRule annotationPRO_0000138385Add
BLAST

Interactioni

Subunit structurei

Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex By similarity.

Protein-protein interaction databases

STRINGi243161.TC0875.

Structurei

3D structure databases

ProteinModelPortaliQ9PJF4.
SMRiQ9PJF4. Positions 16-604.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini39 – 424386Helicase ATP-bindingAdd
BLAST
Domaini441 – 604164Helicase C-terminalAdd
BLAST
Domaini629 – 66436UVRAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi105 – 12824Beta-hairpinUniRule annotationAdd
BLAST

Domaini

The beta-hairpin motif is involved in DNA binding By similarity.UniRule annotation

Sequence similaritiesi

Belongs to the UvrB family.
Contains 1 UVR domain.

Phylogenomic databases

eggNOGiCOG0556.
KOiK03702.
OMAiRVNNDID.
OrthoDBiEOG6B360R.

Family and domain databases

Gene3Di3.40.50.300. 4 hits.
4.10.860.10. 1 hit.
HAMAPiMF_00204. UvrB.
InterProiIPR006935. Helicase/UvrB_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR001943. UVR_dom.
IPR004807. UvrB.
IPR024759. UvrB_YAD/RRR_dom.
[Graphical view]
PANTHERiPTHR24029. PTHR24029. 1 hit.
PfamiPF00271. Helicase_C. 1 hit.
PF04851. ResIII. 1 hit.
PF02151. UVR. 1 hit.
PF12344. UvrB. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF46600. SSF46600. 1 hit.
SSF52540. SSF52540. 3 hits.
TIGRFAMsiTIGR00631. uvrb. 1 hit.
PROSITEiPS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS50151. UVR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9PJF4-1 [UniParc]FASTAAdd to Basket

« Hide

MTHYHNPLNG RKVLNQQFVL QAPFLPCGDQ PEAIRQLSRG ILDGIPSQVL    50
LGTTGSGKTF TMANVIANVN VPTLVLAHNK TLAAQLYQEF KAFFPENAVE 100
YFISYYDYYQ PEAYIARSDT YIEKSLLIND EIDKLRLSAT RSILERRDTL 150
IVSSISCIYG IGSPDNYSSM ALILEVGKEY PRSQLSAQLV RMHYQASASP 200
QRSAFRERGS VIDIFLAYES DLAVRLEFVN DTLVSIEYTD PLTMIPSHTV 250
PSVTLYPGSH YVTPEAVREQ AIRTIREELE QRLLFFEGRP VEQERLFQRT 300
THDIEMIKEI GFCKGIENYS RHFTGAAPGE PPTCLLDYFP EDFLLIIDES 350
HQTLPQLRAM YRGDQSRKQS LVEYGFRLPS AFDNRPLTYE EARRYFRRVV 400
YVSATPGELE VQESRGHIIE QIIRPTGIPD PLPEIRPATG QIDDLLEEIR 450
QRLRKDQEKI LVVSVTKKLA EDIAAFLAEL GIAAAYLHSG IETAERTQIL 500
TDLRLGTIDV LIGVNLLREG IDLPEVSLVA ILDADKEGFL RSSASLIQFC 550
GRAARNVHGK VIFYADRITP SMDHMLKETE RRRQIQLDYN KKHNITPKPI 600
IKPILANPIT KEGAQEDSRP ETQSTEDLES SIKQYEEAMY KAAQDFQFDE 650
AAKYRDLMNA AKRQLLFKQG EDGNSK 676
Length:676
Mass (Da):76,824
Last modified:October 1, 2000 - v1
Checksum:iE611793ED276BDBF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE002160 Genomic DNA. Translation: AAF39671.1.
PIRiD81654.
RefSeqiNP_297248.1. NC_002620.2.

Genome annotation databases

EnsemblBacteriaiAAF39671; AAF39671; TC_0875.
GeneIDi1246243.
KEGGicmu:TC_0875.
PATRICi20373266. VBIChlMur19118_0937.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE002160 Genomic DNA. Translation: AAF39671.1 .
PIRi D81654.
RefSeqi NP_297248.1. NC_002620.2.

3D structure databases

ProteinModelPortali Q9PJF4.
SMRi Q9PJF4. Positions 16-604.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243161.TC0875.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAF39671 ; AAF39671 ; TC_0875 .
GeneIDi 1246243.
KEGGi cmu:TC_0875.
PATRICi 20373266. VBIChlMur19118_0937.

Phylogenomic databases

eggNOGi COG0556.
KOi K03702.
OMAi RVNNDID.
OrthoDBi EOG6B360R.

Enzyme and pathway databases

BioCyci CMUR243161:GHYU-905-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 4 hits.
4.10.860.10. 1 hit.
HAMAPi MF_00204. UvrB.
InterProi IPR006935. Helicase/UvrB_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR001943. UVR_dom.
IPR004807. UvrB.
IPR024759. UvrB_YAD/RRR_dom.
[Graphical view ]
PANTHERi PTHR24029. PTHR24029. 1 hit.
Pfami PF00271. Helicase_C. 1 hit.
PF04851. ResIII. 1 hit.
PF02151. UVR. 1 hit.
PF12344. UvrB. 1 hit.
[Graphical view ]
SMARTi SM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view ]
SUPFAMi SSF46600. SSF46600. 1 hit.
SSF52540. SSF52540. 3 hits.
TIGRFAMsi TIGR00631. uvrb. 1 hit.
PROSITEi PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS50151. UVR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MoPn / Nigg.

Entry informationi

Entry nameiUVRB_CHLMU
AccessioniPrimary (citable) accession number: Q9PJF4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: October 1, 2000
Last modified: May 14, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi