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Q9PJF4

- UVRB_CHLMU

UniProt

Q9PJF4 - UVRB_CHLMU

Protein

UvrABC system protein B

Gene

uvrB

Organism
Chlamydia muridarum (strain MoPn / Nigg)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA2B2 complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.UniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi52 – 598ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. DNA binding Source: UniProtKB-HAMAP
    3. excinuclease ABC activity Source: UniProtKB-HAMAP
    4. helicase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. nucleotide-excision repair Source: UniProtKB-HAMAP
    2. SOS response Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Excision nuclease

    Keywords - Biological processi

    DNA damage, DNA excision, DNA repair, SOS response

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciCMUR243161:GHYU-905-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    UvrABC system protein BUniRule annotation
    Short name:
    Protein UvrBUniRule annotation
    Alternative name(s):
    Excinuclease ABC subunit BUniRule annotation
    Gene namesi
    Name:uvrBUniRule annotation
    Ordered Locus Names:TC_0875
    OrganismiChlamydia muridarum (strain MoPn / Nigg)
    Taxonomic identifieri243161 [NCBI]
    Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
    ProteomesiUP000000800: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 676676UvrABC system protein BPRO_0000138385Add
    BLAST

    Interactioni

    Subunit structurei

    Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.UniRule annotation

    Protein-protein interaction databases

    STRINGi243161.TC0875.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9PJF4.
    SMRiQ9PJF4. Positions 16-604.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini39 – 424386Helicase ATP-bindingUniRule annotationAdd
    BLAST
    Domaini441 – 604164Helicase C-terminalUniRule annotationAdd
    BLAST
    Domaini629 – 66436UVRUniRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi105 – 12824Beta-hairpinAdd
    BLAST

    Domaini

    The beta-hairpin motif is involved in DNA binding.UniRule annotation

    Sequence similaritiesi

    Belongs to the UvrB family.UniRule annotation
    Contains 1 helicase ATP-binding domain.UniRule annotation
    Contains 1 helicase C-terminal domain.UniRule annotation
    Contains 1 UVR domain.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0556.
    KOiK03702.
    OMAiRVNNDID.
    OrthoDBiEOG6B360R.

    Family and domain databases

    Gene3Di3.40.50.300. 4 hits.
    4.10.860.10. 1 hit.
    HAMAPiMF_00204. UvrB.
    InterProiIPR006935. Helicase/UvrB_dom.
    IPR014001. Helicase_ATP-bd.
    IPR001650. Helicase_C.
    IPR027417. P-loop_NTPase.
    IPR001943. UVR_dom.
    IPR004807. UvrB.
    IPR024759. UvrB_YAD/RRR_dom.
    [Graphical view]
    PANTHERiPTHR24029. PTHR24029. 1 hit.
    PfamiPF00271. Helicase_C. 1 hit.
    PF04851. ResIII. 1 hit.
    PF02151. UVR. 1 hit.
    PF12344. UvrB. 1 hit.
    [Graphical view]
    SMARTiSM00487. DEXDc. 1 hit.
    SM00490. HELICc. 1 hit.
    [Graphical view]
    SUPFAMiSSF46600. SSF46600. 1 hit.
    SSF52540. SSF52540. 3 hits.
    TIGRFAMsiTIGR00631. uvrb. 1 hit.
    PROSITEiPS51192. HELICASE_ATP_BIND_1. 1 hit.
    PS51194. HELICASE_CTER. 1 hit.
    PS50151. UVR. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9PJF4-1 [UniParc]FASTAAdd to Basket

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    MTHYHNPLNG RKVLNQQFVL QAPFLPCGDQ PEAIRQLSRG ILDGIPSQVL    50
    LGTTGSGKTF TMANVIANVN VPTLVLAHNK TLAAQLYQEF KAFFPENAVE 100
    YFISYYDYYQ PEAYIARSDT YIEKSLLIND EIDKLRLSAT RSILERRDTL 150
    IVSSISCIYG IGSPDNYSSM ALILEVGKEY PRSQLSAQLV RMHYQASASP 200
    QRSAFRERGS VIDIFLAYES DLAVRLEFVN DTLVSIEYTD PLTMIPSHTV 250
    PSVTLYPGSH YVTPEAVREQ AIRTIREELE QRLLFFEGRP VEQERLFQRT 300
    THDIEMIKEI GFCKGIENYS RHFTGAAPGE PPTCLLDYFP EDFLLIIDES 350
    HQTLPQLRAM YRGDQSRKQS LVEYGFRLPS AFDNRPLTYE EARRYFRRVV 400
    YVSATPGELE VQESRGHIIE QIIRPTGIPD PLPEIRPATG QIDDLLEEIR 450
    QRLRKDQEKI LVVSVTKKLA EDIAAFLAEL GIAAAYLHSG IETAERTQIL 500
    TDLRLGTIDV LIGVNLLREG IDLPEVSLVA ILDADKEGFL RSSASLIQFC 550
    GRAARNVHGK VIFYADRITP SMDHMLKETE RRRQIQLDYN KKHNITPKPI 600
    IKPILANPIT KEGAQEDSRP ETQSTEDLES SIKQYEEAMY KAAQDFQFDE 650
    AAKYRDLMNA AKRQLLFKQG EDGNSK 676
    Length:676
    Mass (Da):76,824
    Last modified:October 1, 2000 - v1
    Checksum:iE611793ED276BDBF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE002160 Genomic DNA. Translation: AAF39671.1.
    PIRiD81654.
    RefSeqiNP_297248.1. NC_002620.2.

    Genome annotation databases

    EnsemblBacteriaiAAF39671; AAF39671; TC_0875.
    GeneIDi1246243.
    KEGGicmu:TC_0875.
    PATRICi20373266. VBIChlMur19118_0937.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE002160 Genomic DNA. Translation: AAF39671.1 .
    PIRi D81654.
    RefSeqi NP_297248.1. NC_002620.2.

    3D structure databases

    ProteinModelPortali Q9PJF4.
    SMRi Q9PJF4. Positions 16-604.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 243161.TC0875.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAF39671 ; AAF39671 ; TC_0875 .
    GeneIDi 1246243.
    KEGGi cmu:TC_0875.
    PATRICi 20373266. VBIChlMur19118_0937.

    Phylogenomic databases

    eggNOGi COG0556.
    KOi K03702.
    OMAi RVNNDID.
    OrthoDBi EOG6B360R.

    Enzyme and pathway databases

    BioCyci CMUR243161:GHYU-905-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 4 hits.
    4.10.860.10. 1 hit.
    HAMAPi MF_00204. UvrB.
    InterProi IPR006935. Helicase/UvrB_dom.
    IPR014001. Helicase_ATP-bd.
    IPR001650. Helicase_C.
    IPR027417. P-loop_NTPase.
    IPR001943. UVR_dom.
    IPR004807. UvrB.
    IPR024759. UvrB_YAD/RRR_dom.
    [Graphical view ]
    PANTHERi PTHR24029. PTHR24029. 1 hit.
    Pfami PF00271. Helicase_C. 1 hit.
    PF04851. ResIII. 1 hit.
    PF02151. UVR. 1 hit.
    PF12344. UvrB. 1 hit.
    [Graphical view ]
    SMARTi SM00487. DEXDc. 1 hit.
    SM00490. HELICc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46600. SSF46600. 1 hit.
    SSF52540. SSF52540. 3 hits.
    TIGRFAMsi TIGR00631. uvrb. 1 hit.
    PROSITEi PS51192. HELICASE_ATP_BIND_1. 1 hit.
    PS51194. HELICASE_CTER. 1 hit.
    PS50151. UVR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MoPn / Nigg.

    Entry informationi

    Entry nameiUVRB_CHLMU
    AccessioniPrimary (citable) accession number: Q9PJF4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 2001
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 91 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3