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Q9PIT8

- DEF_CAMJE

UniProt

Q9PIT8 - DEF_CAMJE

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Protein

Peptide deformylase

Gene
def, Cj0191c
Organism
Campylobacter jejuni subsp. jejuni serotype O:2 (strain NCTC 11168)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions By similarity.UniRule annotation

Catalytic activityi

Formyl-L-methionyl peptide + H2O = formate + methionyl peptide.UniRule annotation

Cofactori

Binds 1 Fe2+ ion By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi96 – 961Iron By similarity
Metal bindingi138 – 1381Iron By similarity
Active sitei139 – 1391 By similarity
Metal bindingi142 – 1421Iron By similarity

GO - Molecular functioni

  1. iron ion binding Source: InterPro
  2. peptide deformylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. translation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

BioCyciCJEJ192222:GJTS-186-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Peptide deformylase (EC:3.5.1.88)
Short name:
PDF
Alternative name(s):
Polypeptide deformylase
Gene namesi
Name:def
Ordered Locus Names:Cj0191c
OrganismiCampylobacter jejuni subsp. jejuni serotype O:2 (strain NCTC 11168)
Taxonomic identifieri192222 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeCampylobacter
ProteomesiUP000000799: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 175175Peptide deformylaseUniRule annotationPRO_0000082757Add
BLAST

Interactioni

Protein-protein interaction databases

IntActiQ9PIT8. 2 interactions.
STRINGi192222.Cj0191c.

Structurei

3D structure databases

ProteinModelPortaliQ9PIT8.
SMRiQ9PIT8. Positions 2-166.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0242.
HOGENOMiHOG000243509.
KOiK01462.
OMAiSWFASEN.
OrthoDBiEOG664CMF.

Family and domain databases

Gene3Di3.90.45.10. 1 hit.
HAMAPiMF_00163. Pep_deformylase.
InterProiIPR000181. Fmet_deformylase.
IPR023635. Peptide_deformylase.
[Graphical view]
PANTHERiPTHR10458. PTHR10458. 1 hit.
PfamiPF01327. Pep_deformylase. 1 hit.
[Graphical view]
PIRSFiPIRSF004749. Pep_def. 1 hit.
PRINTSiPR01576. PDEFORMYLASE.
SUPFAMiSSF56420. SSF56420. 1 hit.
TIGRFAMsiTIGR00079. pept_deformyl. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9PIT8-1 [UniParc]FASTAAdd to Basket

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MVRKIITYPN PRLFLNSEIV NKFDTELHTL LDDMYETMIA SNGVGLAAIQ    50
VDIPLRVLLV NIFDENDEQK KEDLLEIINP EIIPLDEEMI TCTEGCLSVP 100
DFFEEVKRYN HILLKYQDRF GEFKELEAKG FLAVAIQHEN DHLNGHLFIE 150
KISFAKRQKF DKEFKKKKKN HKKEK 175
Length:175
Mass (Da):20,581
Last modified:October 1, 2000 - v1
Checksum:i31F66B96CAB6CC80
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL111168 Genomic DNA. Translation: CAL34360.1.
PIRiF81437.
RefSeqiYP_002343649.1. NC_002163.1.

Genome annotation databases

EnsemblBacteriaiCAL34360; CAL34360; Cj0191c.
GeneIDi904534.
KEGGicje:Cj0191c.
PATRICi20057309. VBICamJej33762_0188.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL111168 Genomic DNA. Translation: CAL34360.1 .
PIRi F81437.
RefSeqi YP_002343649.1. NC_002163.1.

3D structure databases

ProteinModelPortali Q9PIT8.
SMRi Q9PIT8. Positions 2-166.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q9PIT8. 2 interactions.
STRINGi 192222.Cj0191c.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAL34360 ; CAL34360 ; Cj0191c .
GeneIDi 904534.
KEGGi cje:Cj0191c.
PATRICi 20057309. VBICamJej33762_0188.

Phylogenomic databases

eggNOGi COG0242.
HOGENOMi HOG000243509.
KOi K01462.
OMAi SWFASEN.
OrthoDBi EOG664CMF.

Enzyme and pathway databases

BioCyci CJEJ192222:GJTS-186-MONOMER.

Family and domain databases

Gene3Di 3.90.45.10. 1 hit.
HAMAPi MF_00163. Pep_deformylase.
InterProi IPR000181. Fmet_deformylase.
IPR023635. Peptide_deformylase.
[Graphical view ]
PANTHERi PTHR10458. PTHR10458. 1 hit.
Pfami PF01327. Pep_deformylase. 1 hit.
[Graphical view ]
PIRSFi PIRSF004749. Pep_def. 1 hit.
PRINTSi PR01576. PDEFORMYLASE.
SUPFAMi SSF56420. SSF56420. 1 hit.
TIGRFAMsi TIGR00079. pept_deformyl. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NCTC 11168.

Entry informationi

Entry nameiDEF_CAMJE
AccessioniPrimary (citable) accession number: Q9PIT8
Secondary accession number(s): Q0PBU8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 5, 2001
Last sequence update: October 1, 2000
Last modified: May 14, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi