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Q9PIT8

- DEF_CAMJE

UniProt

Q9PIT8 - DEF_CAMJE

Protein

Peptide deformylase

Gene

def

Organism
Campylobacter jejuni subsp. jejuni serotype O:2 (strain NCTC 11168)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.UniRule annotation

    Catalytic activityi

    Formyl-L-methionyl peptide + H2O = formate + methionyl peptide.UniRule annotation

    Cofactori

    Binds 1 Fe2+ ion.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi96 – 961IronUniRule annotation
    Metal bindingi138 – 1381IronUniRule annotation
    Active sitei139 – 1391UniRule annotation
    Metal bindingi142 – 1421IronUniRule annotation

    GO - Molecular functioni

    1. iron ion binding Source: InterPro
    2. peptide deformylase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. translation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    Iron, Metal-binding

    Enzyme and pathway databases

    BioCyciCJEJ192222:GJTS-186-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Peptide deformylaseUniRule annotation (EC:3.5.1.88UniRule annotation)
    Short name:
    PDFUniRule annotation
    Alternative name(s):
    Polypeptide deformylaseUniRule annotation
    Gene namesi
    Name:defUniRule annotation
    Ordered Locus Names:Cj0191c
    OrganismiCampylobacter jejuni subsp. jejuni serotype O:2 (strain NCTC 11168)
    Taxonomic identifieri192222 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeCampylobacter
    ProteomesiUP000000799: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 175175Peptide deformylasePRO_0000082757Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    IntActiQ9PIT8. 2 interactions.
    STRINGi192222.Cj0191c.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9PIT8.
    SMRiQ9PIT8. Positions 2-166.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the polypeptide deformylase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0242.
    HOGENOMiHOG000243509.
    KOiK01462.
    OMAiSWFASEN.
    OrthoDBiEOG664CMF.

    Family and domain databases

    Gene3Di3.90.45.10. 1 hit.
    HAMAPiMF_00163. Pep_deformylase.
    InterProiIPR000181. Fmet_deformylase.
    IPR023635. Peptide_deformylase.
    [Graphical view]
    PANTHERiPTHR10458. PTHR10458. 1 hit.
    PfamiPF01327. Pep_deformylase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF004749. Pep_def. 1 hit.
    PRINTSiPR01576. PDEFORMYLASE.
    SUPFAMiSSF56420. SSF56420. 1 hit.
    TIGRFAMsiTIGR00079. pept_deformyl. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9PIT8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVRKIITYPN PRLFLNSEIV NKFDTELHTL LDDMYETMIA SNGVGLAAIQ    50
    VDIPLRVLLV NIFDENDEQK KEDLLEIINP EIIPLDEEMI TCTEGCLSVP 100
    DFFEEVKRYN HILLKYQDRF GEFKELEAKG FLAVAIQHEN DHLNGHLFIE 150
    KISFAKRQKF DKEFKKKKKN HKKEK 175
    Length:175
    Mass (Da):20,581
    Last modified:October 1, 2000 - v1
    Checksum:i31F66B96CAB6CC80
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL111168 Genomic DNA. Translation: CAL34360.1.
    PIRiF81437.
    RefSeqiYP_002343649.1. NC_002163.1.

    Genome annotation databases

    EnsemblBacteriaiCAL34360; CAL34360; Cj0191c.
    GeneIDi904534.
    KEGGicje:Cj0191c.
    PATRICi20057309. VBICamJej33762_0188.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL111168 Genomic DNA. Translation: CAL34360.1 .
    PIRi F81437.
    RefSeqi YP_002343649.1. NC_002163.1.

    3D structure databases

    ProteinModelPortali Q9PIT8.
    SMRi Q9PIT8. Positions 2-166.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q9PIT8. 2 interactions.
    STRINGi 192222.Cj0191c.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAL34360 ; CAL34360 ; Cj0191c .
    GeneIDi 904534.
    KEGGi cje:Cj0191c.
    PATRICi 20057309. VBICamJej33762_0188.

    Phylogenomic databases

    eggNOGi COG0242.
    HOGENOMi HOG000243509.
    KOi K01462.
    OMAi SWFASEN.
    OrthoDBi EOG664CMF.

    Enzyme and pathway databases

    BioCyci CJEJ192222:GJTS-186-MONOMER.

    Family and domain databases

    Gene3Di 3.90.45.10. 1 hit.
    HAMAPi MF_00163. Pep_deformylase.
    InterProi IPR000181. Fmet_deformylase.
    IPR023635. Peptide_deformylase.
    [Graphical view ]
    PANTHERi PTHR10458. PTHR10458. 1 hit.
    Pfami PF01327. Pep_deformylase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF004749. Pep_def. 1 hit.
    PRINTSi PR01576. PDEFORMYLASE.
    SUPFAMi SSF56420. SSF56420. 1 hit.
    TIGRFAMsi TIGR00079. pept_deformyl. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: NCTC 11168.

    Entry informationi

    Entry nameiDEF_CAMJE
    AccessioniPrimary (citable) accession number: Q9PIT8
    Secondary accession number(s): Q0PBU8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 5, 2001
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 85 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3