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Q9PIS4 (UPPP_CAMJE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase

EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene names
Name:uppP
Synonyms:bacA, upk
Ordered Locus Names:Cj0205
OrganismCampylobacter jejuni subsp. jejuni serotype O:2 (strain NCTC 11168) [Reference proteome] [HAMAP]
Taxonomic identifier192222 [NCBI]
Taxonomic lineageBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeCampylobacter

Protein attributes

Sequence length267 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Sequence similarities

Belongs to the UppP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 267267Undecaprenyl-diphosphatase HAMAP-Rule MF_01006
PRO_0000151128

Regions

Transmembrane4 – 2421Helical; Potential
Transmembrane41 – 6121Helical; Potential
Transmembrane69 – 8921Helical; Potential
Transmembrane96 – 11621Helical; Potential
Transmembrane173 – 19321Helical; Potential
Transmembrane207 – 22721Helical; Potential
Transmembrane239 – 25921Helical; Potential

Experimental info

Sequence conflict211I → V in CAA53663. Ref.2
Sequence conflict1131F → L in CAA53663. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q9PIS4 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: 41496EE123753DDA

FASTA26729,751
        10         20         30         40         50         60 
MENLYALILG IIEGLTEFLP ISSTGHMILG TTILGIDIDE FWKSFLIIIQ LGSILAVIFV 

        70         80         90        100        110        120 
FWRKLFQGLD IWLKLAVGFF PTGVIGLFVA KYLNALFNGW VVVGMLIFGG VVFILIELAH 

       130        140        150        160        170        180 
KNKQYRINSL EEISFKQAFC IGIFQSLAMI PGTSRSGASI IGGLLLEFNR KVAAEFSFLL 

       190        200        210        220        230        240 
AIPTMIIATA YSIYKEPELL GNANSLIPLG IGFITAFIVA VLVIKFFLKF ISKFDFIPFG 

       250        260 
IYRIILGFVF FYLYYSGILN AGSEFKL 

« Hide

References

« Hide 'large scale' references
[1]"The genome sequence of the food-borne pathogen Campylobacter jejuni reveals hypervariable sequences."
Parkhill J., Wren B.W., Mungall K.L., Ketley J.M., Churcher C.M., Basham D., Chillingworth T., Davies R.M., Feltwell T., Holroyd S., Jagels K., Karlyshev A.V., Moule S., Pallen M.J., Penn C.W., Quail M.A., Rajandream M.A., Rutherford K.M. expand/collapse author list , van Vliet A.H.M., Whitehead S., Barrell B.G.
Nature 403:665-668(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: NCTC 11168.
[2]"Identification of Campylobacter jejuni and C.coli using the rpoB gene and a cryptic DNA fragment from C.jejuni."
Bustamante V.H., Puente J.L., Sanchez-Lopez F., Bobadilla M., Calva E.
Gene 165:1-8(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-138.
Strain: 386-IP.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL111168 Genomic DNA. Translation: CAL34374.1.
X76062 Genomic DNA. Translation: CAA53663.1.
PIRD81439.
S38664.
RefSeqYP_002343663.1. NC_002163.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING192222.Cj0205.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAL34374; CAL34374; Cj0205.
GeneID904549.
KEGGcje:Cj0205.
PATRIC20057337. VBICamJej33762_0202.

Phylogenomic databases

eggNOGCOG1968.
HOGENOMHOG000218356.
KOK06153.
OMAFNDAHAK.
OrthoDBEOG6QP13M.

Enzyme and pathway databases

BioCycCJEJ192222:GJTS-200-MONOMER.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR003824. UppP.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsTIGR00753. undec_PP_bacA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameUPPP_CAMJE
AccessionPrimary (citable) accession number: Q9PIS4
Secondary accession number(s): Q0PBT4, Q46111
Entry history
Integrated into UniProtKB/Swiss-Prot: March 5, 2002
Last sequence update: October 1, 2000
Last modified: May 14, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families