Q9PIS4 (UPPP_CAMJE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Undecaprenyl-diphosphatase
EC=3.6.1.27

Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase

Gene names

Name:	uppP
Synonyms:	bacA, upk
Ordered Locus Names:	Cj0205

Organism

Campylobacter jejuni subsp. jejuni serotype O:2 (strain NCTC 11168) [Reference proteome] [HAMAP]

Taxonomic identifier

192222 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › delta/epsilon subdivisions › Epsilonproteobacteria › Campylobacterales › Campylobacteraceae › Campylobacter › Campylobacter jejuni › Campylobacter jejuni subsp. jejuni

Protein attributes

Sequence length	267 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006
Catalytic activity	Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006
Subcellular location	Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.
Miscellaneous	Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available. HAMAP-Rule MF_01006
Sequence similarities	Belongs to the UppP family.

Ontologies

Keywords
Biological process	Antibiotic resistance Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	dephosphorylation Inferred from electronic annotation. Source: InterPro peptidoglycan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW response to antibiotic Inferred from electronic annotation. Source: HAMAP
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	undecaprenyl-diphosphatase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 267	267	Undecaprenyl-diphosphatase HAMAP-Rule MF_01006		PRO_0000151128
Regions
	Transmembrane	4 – 24	21	Helical; Potential
	Transmembrane	41 – 61	21	Helical; Potential
	Transmembrane	69 – 89	21	Helical; Potential
	Transmembrane	96 – 116	21	Helical; Potential
	Transmembrane	173 – 193	21	Helical; Potential
	Transmembrane	207 – 227	21	Helical; Potential
	Transmembrane	239 – 259	21	Helical; Potential
Experimental info
	Sequence conflict	21	1	I → V in CAA53663. Ref.2
	Sequence conflict	113	1	F → L in CAA53663. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q9PIS4 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: 41496EE123753DDA	FASTA	267	29,751
	10 20 30 40 50 60 MENLYALILG IIEGLTEFLP ISSTGHMILG TTILGIDIDE FWKSFLIIIQ LGSILAVIFV 70 80 90 100 110 120 FWRKLFQGLD IWLKLAVGFF PTGVIGLFVA KYLNALFNGW VVVGMLIFGG VVFILIELAH 130 140 150 160 170 180 KNKQYRINSL EEISFKQAFC IGIFQSLAMI PGTSRSGASI IGGLLLEFNR KVAAEFSFLL 190 200 210 220 230 240 AIPTMIIATA YSIYKEPELL GNANSLIPLG IGFITAFIVA VLVIKFFLKF ISKFDFIPFG 250 260 IYRIILGFVF FYLYYSGILN AGSEFKL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The genome sequence of the food-borne pathogen Campylobacter jejuni reveals hypervariable sequences." Parkhill J., Wren B.W., Mungall K.L., Ketley J.M., Churcher C.M., Basham D., Chillingworth T., Davies R.M., Feltwell T., Holroyd S., Jagels K., Karlyshev A.V., Moule S., Pallen M.J., Penn C.W., Quail M.A., Rajandream M.A., Rutherford K.M. , van Vliet A.H.M., Whitehead S., Barrell B.G. Nature 403:665-668(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: NCTC 11168.
[2]	"Identification of Campylobacter jejuni and C.coli using the rpoB gene and a cryptic DNA fragment from C.jejuni." Bustamante V.H., Puente J.L., Sanchez-Lopez F., Bobadilla M., Calva E. Gene 165:1-8(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-138. Strain: 386-IP.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL111168 Genomic DNA. Translation: CAL34374.1. X76062 Genomic DNA. Translation: CAA53663.1.
PIR	D81439. S38664.
RefSeq	YP_002343663.1. NC_002163.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	192222.Cj0205.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAL34374; CAL34374; Cj0205.
GeneID	904549.
KEGG	cje:Cj0205.
PATRIC	20057337. VBICamJej33762_0202.
Phylogenomic databases
eggNOG	COG1968.
HOGENOM	HOG000218356.
KO	K06153.
OMA	NDWLDKH.
ProtClustDB	CLSK878691.
Enzyme and pathway databases
BioCyc	CJEJ192222:GJTS-200-MONOMER.
Family and domain databases
HAMAP	MF_01006. Undec_diphosphatase.
InterPro	IPR003824. Bacitracin-R_BacA. [Graphical view]
Pfam	PF02673. BacA. 1 hit. [Graphical view]
TIGRFAMs	TIGR00753. undec_PP_bacA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

UPPP_CAMJE

Accession

Primary (citable) accession number: Q9PIS4
Secondary accession number(s): Q0PBT4, Q46111

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 5, 2002
Last sequence update:	October 1, 2000
Last modified:	May 1, 2013
This is version 79 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program