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Protein

Undecaprenyl-diphosphatase

Gene

uppP

Organism
Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Catalytic activityi

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processAntibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciCJEJ192222:G1G1F-197-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl-diphosphataseUniRule annotation (EC:3.6.1.27UniRule annotation)
Alternative name(s):
Bacitracin resistance proteinUniRule annotation
Undecaprenyl pyrophosphate phosphataseUniRule annotation
Gene namesi
Name:uppPUniRule annotation
Synonyms:bacA, upk
Ordered Locus Names:Cj0205
OrganismiCampylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168)
Taxonomic identifieri192222 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeCampylobacter
Proteomesi
  • UP000000799 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei4 – 24HelicalUniRule annotationAdd BLAST21
Transmembranei41 – 61HelicalUniRule annotationAdd BLAST21
Transmembranei69 – 89HelicalUniRule annotationAdd BLAST21
Transmembranei96 – 116HelicalUniRule annotationAdd BLAST21
Transmembranei173 – 193HelicalUniRule annotationAdd BLAST21
Transmembranei207 – 227HelicalUniRule annotationAdd BLAST21
Transmembranei239 – 259HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001511281 – 267Undecaprenyl-diphosphataseAdd BLAST267

Proteomic databases

PaxDbiQ9PIS4

Interactioni

Protein-protein interaction databases

IntActiQ9PIS4, 1 interactor
STRINGi192222.Cj0205

Family & Domainsi

Sequence similaritiesi

Belongs to the UppP family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105DWR Bacteria
COG1968 LUCA
HOGENOMiHOG000218356
KOiK06153
OMAiPDARMGW

Family and domain databases

HAMAPiMF_01006 Undec_diphosphatase, 1 hit
InterProiView protein in InterPro
IPR003824 UppP
PANTHERiPTHR30622 PTHR30622, 1 hit
PfamiView protein in Pfam
PF02673 BacA, 1 hit
TIGRFAMsiTIGR00753 undec_PP_bacA, 1 hit

Sequencei

Sequence statusi: Complete.

Q9PIS4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENLYALILG IIEGLTEFLP ISSTGHMILG TTILGIDIDE FWKSFLIIIQ
60 70 80 90 100
LGSILAVIFV FWRKLFQGLD IWLKLAVGFF PTGVIGLFVA KYLNALFNGW
110 120 130 140 150
VVVGMLIFGG VVFILIELAH KNKQYRINSL EEISFKQAFC IGIFQSLAMI
160 170 180 190 200
PGTSRSGASI IGGLLLEFNR KVAAEFSFLL AIPTMIIATA YSIYKEPELL
210 220 230 240 250
GNANSLIPLG IGFITAFIVA VLVIKFFLKF ISKFDFIPFG IYRIILGFVF
260
FYLYYSGILN AGSEFKL
Length:267
Mass (Da):29,751
Last modified:October 1, 2000 - v1
Checksum:i41496EE123753DDA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti21I → V in CAA53663 (PubMed:7489896).Curated1
Sequence conflicti113F → L in CAA53663 (PubMed:7489896).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL111168 Genomic DNA Translation: CAL34374.1
X76062 Genomic DNA Translation: CAA53663.1
PIRiD81439
S38664
RefSeqiWP_002836742.1, NC_002163.1
YP_002343663.1, NC_002163.1

Genome annotation databases

EnsemblBacteriaiCAL34374; CAL34374; Cj0205
GeneIDi904549
KEGGicje:Cj0205
PATRICifig|192222.6.peg.202

Similar proteinsi

Entry informationi

Entry nameiUPPP_CAMJE
AccessioniPrimary (citable) accession number: Q9PIS4
Secondary accession number(s): Q0PBT4, Q46111
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 5, 2002
Last sequence update: October 1, 2000
Last modified: March 28, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health