Q9PIS0 (ARGC_CAMJE) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 80.
History...
Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: N-acetyl-gamma-glutamyl-phosphate reductase Short name=AGPR EC=1.2.1.38 Alternative name(s): N-acetyl-glutamate semialdehyde dehydrogenase Short name=NAGSA dehydrogenase | ||||
| Gene names |
| ||||
| Organism | Campylobacter jejuni | ||||
| Taxonomic identifier | 197 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Campylobacteraceae › Campylobacter |
Protein attributes
| Sequence length | 342 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Catalytic activity | N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate = N-acetyl-5-glutamyl phosphate + NADPH. HAMAP MF_00150 |
| Pathway | Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 3/4. HAMAP MF_00150 |
| Subcellular location | Cytoplasm Probable HAMAP MF_00150. |
| Sequence similarities | Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Amino-acid biosynthesis Arginine biosynthesis |
| Cellular component | Cytoplasm |
| Ligand | NADP |
| Molecular function | Oxidoreductase |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological process | arginine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | N-acetyl-gamma-glutamyl-phosphate reductase activity Inferred from electronic annotation. Source: EC NAD bindingInferred from electronic annotation. Source: InterPro protein dimerization activityInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Binary interactions
With | Entry | #Exp. | IntAct | Notes |
|---|---|---|---|---|
| flaG | Q0PAW9 | 1 | EBI-1195272,EBI-1191365 |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 342 | 342 | N-acetyl-gamma-glutamyl-phosphate reductase HAMAP MF_00150 | PRO_0000112393 | |||||
Sites | |||||||||
| Active site | 147 | 1 | By similarity | ||||||
Experimental info | |||||||||
| Sequence conflict | 76 | 1 | K → E in AAF21802. Ref.1 | ||||||
| Sequence conflict | 119 | 1 | E → D in AAF21802. Ref.1 | ||||||
| Sequence conflict | 168 | 1 | S → N in AAF21802. Ref.1 | ||||||
| Sequence conflict | 194 | 1 | V → I in AAF21802. Ref.1 | ||||||
| Sequence conflict | 202 | 1 | N → G in AAF21802. Ref.1 | ||||||
| Sequence conflict | 205 | 1 | L → S in AAF21802. Ref.1 | ||||||
| Sequence conflict | 296 | 1 | V → I in AAF21802. Ref.1 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Arginine biosynthesis in Campylobacter jejuni TGH9011: determination of the argCOBD cluster." Hani E.K., Ng D., Chan V.-L. Can. J. Microbiol. 45:959-969(1999) [PubMed: 10588044] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 43431 / TGH 9011 / Serotype O:3. |
| [2] | "The genome sequence of the food-borne pathogen Campylobacter jejuni reveals hypervariable sequences." Parkhill J., Wren B.W., Mungall K.L., Ketley J.M., Churcher C.M., Basham D., Chillingworth T., Davies R.M., Feltwell T., Holroyd S., Jagels K., Karlyshev A.V., Moule S., Pallen M.J., Penn C.W., Quail M.A., Rajandream M.A., Rutherford K.M. Barrell B.G.Nature 403:665-668(2000) [PubMed: 10688204] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: NCTC 11168 / Serotype O:2. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AF093219 Genomic DNA. Translation: AAF21802.1. AL111168 Genomic DNA. Translation: CAL34379.1. |
| PIR | H81439. |
| RefSeq | YP_002343667.1. NC_002163.1. |
3D structure databases | |
| ProteinModelPortal | Q9PIS0. |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | Q9PIS0. 35 interactions. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| GeneID | 906012. |
| GenomeReviews | Gene locus Cj0224 in contig AL111168_GR. |
| KEGG | cje:Cj0224. |
| PATRIC | 20057369. VBICamJej33762_0218. |
Phylogenomic databases | |
| HOGENOM | HBG294213. |
| OMA | VCRIAVH. |
| ProtClustDB | PRK00436. |
Enzyme and pathway databases | |
| BioCyc | CJEJ192222:CJ0224-MONOMER. |
Family and domain databases | |
| HAMAP | MF_00150. ArgC_type1. [Tree] |
| InterPro | IPR023013. AGPR_AS. IPR000706. AGPR_type-1. IPR016040. NAD(P)-bd_dom. IPR000534. Semialdehyde_DH_NAD-bd. IPR012280. Semialdhyde_DH_dimer_dom. [Graphical view] |
| Gene3D | G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. |
| KO | K00145. |
| Pfam | PF01118. Semialdhyde_dh. 1 hit. PF02774. Semialdhyde_dhC. 1 hit. [Graphical view] |
| SMART | SM00859. Semialdhyde_dh. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR01850. ArgC. 1 hit. |
| PROSITE | PS01224. ARGC. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | ARGC_CAMJE | ||||||||
| Accession | Primary (citable) accession number: Q9PIS0 Secondary accession number(s): Q0PBT0, Q9RH00 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

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