Q9PIM0 (CLPX_CAMJE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
ATP-dependent Clp protease ATP-binding subunit ClpX

Gene names

Name:	clpX
Ordered Locus Names:	Cj0275

Organism

Campylobacter jejuni subsp. jejuni serotype O:2 (strain NCTC 11168) [Reference proteome] [HAMAP]

Taxonomic identifier

192222 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › delta/epsilon subdivisions › Epsilonproteobacteria › Campylobacterales › Campylobacteraceae › Campylobacter › Campylobacter jejuni › Campylobacter jejuni subsp. jejuni

Protein attributes

Sequence length	417 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP By similarity. HAMAP-Rule MF_00175
Subunit structure	Heterodimer of ClpP and ClpX By similarity.
Sequence similarities	Belongs to the ClpX chaperone family.

Ontologies

Keywords
Domain	Zinc-finger
Ligand	ATP-binding Metal-binding Nucleotide-binding Zinc
Molecular function	Chaperone
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	protein folding Inferred from electronic annotation. Source: HAMAP
Molecular_function	ATP binding Inferred from electronic annotation. Source: HAMAP nucleoside-triphosphatase activity Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 417	417	ATP-dependent Clp protease ATP-binding subunit ClpX HAMAP-Rule MF_00175		PRO_0000160333
Regions
	Zinc finger	15 – 42	28	C4-type HAMAP-Rule MF_00175
	Nucleotide binding	126 – 133	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	Q9PIM0 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: 09AF6400AA99CCCD	FASTA	417	47,049
	10 20 30 40 50 60 MEFLSIGVKI MPRKCSFCNE VENPQRRILA NENDDAFICE YCVEGAYSII YGEEKEFKEP 70 80 90 100 110 120 KQSHNTEFKD ITPKELKAYL DRYVIGQDRA KKVFSVGVYN HYKRLFKAEL QDDDTELFKS 130 140 150 160 170 180 NILLVGPTGS GKTLLAQTLA KFLDVPIAIC DATSLTEAGY VGEDVENILT RLLQAADGDV 190 200 210 220 230 240 QRAQKGIVFI DEIDKIARMS ENRSITRDVS GEGVQQALLK IIEGSLVNIP PRGGRKHPNQ 250 260 270 280 290 300 EFIQIDTSNI LFVCGGAFDG LETILKRKLG DKVVGFFDDA KEENKALLEK IEPDDLVHFG 310 320 330 340 350 360 LIPELIGRLH VIASLNELNE EDMVRILTEP KNAIIKQYQK LFAIDGVNLK FEEDALRAIA 370 380 390 400 410 QLALERKTGA RGLRSIIEEM MVDLMFELPE YKDYDIVITK EVVKDNAKAL LIKRKIS

References

[1]

"The genome sequence of the food-borne pathogen Campylobacter jejuni reveals hypervariable sequences." Parkhill J., Wren B.W., Mungall K.L., Ketley J.M., Churcher C.M., Basham D., Chillingworth T., Davies R.M., Feltwell T., Holroyd S., Jagels K., Karlyshev A.V., Moule S., Pallen M.J., Penn C.W., Quail M.A., Rajandream M.A., Rutherford K.M. , van Vliet A.H.M., Whitehead S., Barrell B.G. Nature 403:665-668(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: NCTC 11168.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL111168 Genomic DNA. Translation: CAL34429.1.
PIR	B81446.
RefSeq	YP_002343717.1. NC_002163.1.
3D structure databases
ProteinModelPortal	Q9PIM0.
SMR	Q9PIM0. Positions 72-412.
ModBase	Search...
Protein-protein interaction databases
STRING	192222.Cj0275.
Proteomic databases
PRIDE	Q9PIM0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAL34429; CAL34429; Cj0275.
GeneID	904600.
KEGG	cje:Cj0275.
PATRIC	20057471. VBICamJej33762_0269.
Phylogenomic databases
eggNOG	COG1219.
HOGENOM	HOG000010093.
KO	K03544.
OMA	IMFEVPS.
ProtClustDB	PRK05342.
Enzyme and pathway databases
BioCyc	CJEJ192222:GJTS-255-MONOMER.
Family and domain databases
HAMAP	MF_00175. ClpX.
InterPro	IPR003593. AAA+_ATPase. IPR013093. ATPase_AAA-2. IPR019489. Clp_ATPase_C. IPR004487. Clp_protease_ATP-bd_su_ClpX. IPR025943. Sigma_54_int_dom_ATP-bd_2. IPR010603. Znf_CppX_C4. [Graphical view]
PANTHER	PTHR11262:SF4. PTHR11262:SF4. 1 hit.
Pfam	PF07724. AAA_2. 1 hit. PF10431. ClpB_D2-small. 1 hit. PF06689. zf-C4_ClpX. 1 hit. [Graphical view]
SMART	SM00382. AAA. 1 hit. SM01086. ClpB_D2-small. 1 hit. SM00994. zf-C4_ClpX. 1 hit. [Graphical view]
TIGRFAMs	TIGR00382. clpX. 1 hit.
ProtoNet	Search...

Entry information

Entry name

CLPX_CAMJE

Accession

Primary (citable) accession number: Q9PIM0
Secondary accession number(s): Q0PBN0

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 27, 2002
Last sequence update:	October 1, 2000
Last modified:	May 1, 2013
This is version 77 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program