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Q9PIK8

- LPXB_CAMJE

UniProt

Q9PIK8 - LPXB_CAMJE

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Protein

Lipid-A-disaccharide synthase

Gene

lpxB

Organism
Campylobacter jejuni subsp. jejuni serotype O:2 (strain NCTC 11168)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.By similarity

Catalytic activityi

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.

Pathwayi

GO - Molecular functioni

  1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid A biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciCJEJ192222:GJTS-267-MONOMER.
UniPathwayiUPA00359; UER00481.

Protein family/group databases

CAZyiGT19. Glycosyltransferase Family 19.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid-A-disaccharide synthase (EC:2.4.1.182)
Gene namesi
Name:lpxB
Ordered Locus Names:Cj0288c
OrganismiCampylobacter jejuni subsp. jejuni serotype O:2 (strain NCTC 11168)
Taxonomic identifieri192222 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeCampylobacter
ProteomesiUP000000799: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 364364Lipid-A-disaccharide synthasePRO_0000190156Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi192222.Cj0288c.

Structurei

3D structure databases

ProteinModelPortaliQ9PIK8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LpxB family.Curated

Phylogenomic databases

eggNOGiCOG0763.
HOGENOMiHOG000018004.
KOiK00748.
OMAiEWTINPP.
OrthoDBiEOG6FBWZR.

Family and domain databases

HAMAPiMF_00392. LpxB.
InterProiIPR003835. Glyco_trans_19.
[Graphical view]
PfamiPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00215. lpxB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9PIK8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKTFLVCALE PSANLHLKEV LKAYKKDFGE FELHGIYDES LCKEFDLNSK
60 70 80 90 100
PLYSSHEFSA MGFIEVLPLI FKAKKAIKEL ANLSFTQKIN GILCIDSPAF
110 120 130 140 150
NIPFAKALKK AGSKIPRIYY ILPQVWAWKK GRIPIIESHF DILASILPFD
160 170 180 190 200
NQFFNKSTYI GHPLLDEIKE FKNQEDINHT FSKKDDEKTI AFLPGSRRSE
210 220 230 240 250
IRRLMPIFKE LSQKFKGKKI LCVPSFNLEK LEVYGDISEF KIESNTPKVL
260 270 280 290 300
KKADFAFICS GTATLEAALV GTPFVLAYKA KAIDIFIAKL FVKLKHIGLA
310 320 330 340 350
NIFCDFAGKE ALNPEFLQDK VNVLNLYEAY NKYDYKAFFA KVDFLKEYLQ
360
FGSAKNLAKI LNEI
Length:364
Mass (Da):41,581
Last modified:October 1, 2000 - v1
Checksum:i53DA0DA1979A2C5F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL111168 Genomic DNA. Translation: CAL34441.1.
PIRiF81447.
RefSeqiYP_002343729.1. NC_002163.1.

Genome annotation databases

EnsemblBacteriaiCAL34441; CAL34441; Cj0288c.
GeneIDi904612.
KEGGicje:Cj0288c.
PATRICi20057495. VBICamJej33762_0281.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL111168 Genomic DNA. Translation: CAL34441.1 .
PIRi F81447.
RefSeqi YP_002343729.1. NC_002163.1.

3D structure databases

ProteinModelPortali Q9PIK8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 192222.Cj0288c.

Protein family/group databases

CAZyi GT19. Glycosyltransferase Family 19.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAL34441 ; CAL34441 ; Cj0288c .
GeneIDi 904612.
KEGGi cje:Cj0288c.
PATRICi 20057495. VBICamJej33762_0281.

Phylogenomic databases

eggNOGi COG0763.
HOGENOMi HOG000018004.
KOi K00748.
OMAi EWTINPP.
OrthoDBi EOG6FBWZR.

Enzyme and pathway databases

UniPathwayi UPA00359 ; UER00481 .
BioCyci CJEJ192222:GJTS-267-MONOMER.

Family and domain databases

HAMAPi MF_00392. LpxB.
InterProi IPR003835. Glyco_trans_19.
[Graphical view ]
Pfami PF02684. LpxB. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00215. lpxB. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NCTC 11168.

Entry informationi

Entry nameiLPXB_CAMJE
AccessioniPrimary (citable) accession number: Q9PIK8
Secondary accession number(s): Q0PBL8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: October 1, 2000
Last modified: October 1, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3