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Protein

Pantothenate synthetase

Gene

panC

Organism
Campylobacter jejuni subsp. jejuni serotype O:2 (strain NCTC 11168)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.UniRule annotation

Catalytic activityi

ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei37 – 371Proton donorUniRule annotation
Binding sitei60 – 601Beta-alanineUniRule annotation
Binding sitei60 – 601PantoateUniRule annotation
Binding sitei152 – 1521PantoateUniRule annotation
Binding sitei175 – 1751ATP; via amide nitrogen and carbonyl oxygenUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi30 – 378ATPUniRule annotation
Nucleotide bindingi146 – 1494ATPUniRule annotation
Nucleotide bindingi183 – 1864ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Pantothenate biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCJEJ192222:GJTS-274-MONOMER.
UniPathwayiUPA00028; UER00005.

Names & Taxonomyi

Protein namesi
Recommended name:
Pantothenate synthetaseUniRule annotation (EC:6.3.2.1UniRule annotation)
Short name:
PSUniRule annotation
Alternative name(s):
Pantoate--beta-alanine ligaseUniRule annotation
Pantoate-activating enzymeUniRule annotation
Gene namesi
Name:panCUniRule annotation
Ordered Locus Names:Cj0297c
OrganismiCampylobacter jejuni subsp. jejuni serotype O:2 (strain NCTC 11168)
Taxonomic identifieri192222 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeCampylobacter
ProteomesiUP000000799 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 282282Pantothenate synthetasePRO_0000128216Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

IntActiQ9PIK2. 30 interactions.
STRINGi192222.Cj0297c.

Structurei

Secondary structure

1
282
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi2 – 43Combined sources
Helixi7 – 1913Combined sources
Beta strandi24 – 296Combined sources
Helixi35 – 4410Combined sources
Beta strandi47 – 548Combined sources
Helixi58 – 603Combined sources
Turni67 – 693Combined sources
Helixi74 – 8310Combined sources
Beta strandi87 – 904Combined sources
Helixi94 – 974Combined sources
Beta strandi109 – 1113Combined sources
Helixi115 – 1195Combined sources
Helixi123 – 13816Combined sources
Beta strandi141 – 1466Combined sources
Helixi147 – 1493Combined sources
Helixi150 – 16213Combined sources
Beta strandi166 – 1727Combined sources
Helixi185 – 1895Combined sources
Helixi192 – 21322Combined sources
Helixi219 – 23113Combined sources
Beta strandi236 – 2449Combined sources
Turni246 – 2483Combined sources
Beta strandi259 – 2679Combined sources
Beta strandi270 – 2789Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3MXTX-ray1.85A1-282[»]
3UY4X-ray1.85A1-282[»]
ProteinModelPortaliQ9PIK2.
SMRiQ9PIK2. Positions 1-278.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9PIK2.

Family & Domainsi

Sequence similaritiesi

Belongs to the pantothenate synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0414.
HOGENOMiHOG000175517.
KOiK01918.
OMAiENVDCIF.
OrthoDBiEOG6Z6FZ4.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00158. PanC.
InterProiIPR003721. Pantoate_ligase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERiPTHR21299:SF1. PTHR21299:SF1. 1 hit.
PfamiPF02569. Pantoate_ligase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00018. panC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9PIK2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQVITSVKEA KQIVKDWKSH QLSIGYVPTM GFLHDGHLSL VKHAKTQDKV
60 70 80 90 100
IVSIFVNPMQ FGPNEDFSSY PRDLERDIKM CQDNGVDMVF IPDATQMYLK
110 120 130 140 150
NFSTYVDMNT ITDKLCGAKR PGHFRGVCTV LTKFFNILNP DIVYMGQKDA
160 170 180 190 200
QQCVVVRHMV DDLNFDLKIQ ICPIIREEDG LAKSSRNVYL SKEERKASLA
210 220 230 240 250
ISQSIFLAEK LVREGEKNTS KIIQAMKDIL EKEKLIKIDY IELVDFNTME
260 270 280
NIENITDNVL GAVAAFVGKT RLIDNFLVQG LK
Length:282
Mass (Da):32,087
Last modified:December 1, 2000 - v1
Checksum:iC8946F933D7B6475
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL111168 Genomic DNA. Translation: CAL34448.1.
PIRiE81448.
RefSeqiWP_002778123.1. NC_002163.1.
YP_002343735.1. NC_002163.1.

Genome annotation databases

EnsemblBacteriaiCAL34448; CAL34448; Cj0297c.
GeneIDi904621.
KEGGicje:Cj0297c.
PATRICi20057511. VBICamJej33762_0289.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL111168 Genomic DNA. Translation: CAL34448.1.
PIRiE81448.
RefSeqiWP_002778123.1. NC_002163.1.
YP_002343735.1. NC_002163.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3MXTX-ray1.85A1-282[»]
3UY4X-ray1.85A1-282[»]
ProteinModelPortaliQ9PIK2.
SMRiQ9PIK2. Positions 1-278.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9PIK2. 30 interactions.
STRINGi192222.Cj0297c.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAL34448; CAL34448; Cj0297c.
GeneIDi904621.
KEGGicje:Cj0297c.
PATRICi20057511. VBICamJej33762_0289.

Phylogenomic databases

eggNOGiCOG0414.
HOGENOMiHOG000175517.
KOiK01918.
OMAiENVDCIF.
OrthoDBiEOG6Z6FZ4.

Enzyme and pathway databases

UniPathwayiUPA00028; UER00005.
BioCyciCJEJ192222:GJTS-274-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ9PIK2.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00158. PanC.
InterProiIPR003721. Pantoate_ligase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERiPTHR21299:SF1. PTHR21299:SF1. 1 hit.
PfamiPF02569. Pantoate_ligase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00018. panC. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NCTC 11168.

Entry informationi

Entry nameiPANC_CAMJE
AccessioniPrimary (citable) accession number: Q9PIK2
Secondary accession number(s): Q0PBL2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: May 27, 2015
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

The reaction proceeds by a bi uni uni bi ping pong mechanism.UniRule annotation

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.