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Protein

Pantothenate synthetase

Gene

panC

Organism
Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.UniRule annotation

Catalytic activityi

ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate.UniRule annotation

Pathwayi: (R)-pantothenate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes (R)-pantothenate from (R)-pantoate and beta-alanine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Pantothenate synthetase (panC)
This subpathway is part of the pathway (R)-pantothenate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (R)-pantothenate from (R)-pantoate and beta-alanine, the pathway (R)-pantothenate biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei37Proton donorUniRule annotation1
Binding sitei60Beta-alanineUniRule annotation1
Binding sitei60PantoateUniRule annotation1
Binding sitei152PantoateUniRule annotation1
Binding sitei175ATP; via amide nitrogen and carbonyl oxygenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi30 – 37ATPUniRule annotation8
Nucleotide bindingi146 – 149ATPUniRule annotation4
Nucleotide bindingi183 – 186ATPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Pantothenate biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCJEJ192222:GJTS-266-MONOMER.
UniPathwayiUPA00028; UER00005.

Names & Taxonomyi

Protein namesi
Recommended name:
Pantothenate synthetaseUniRule annotation (EC:6.3.2.1UniRule annotation)
Short name:
PSUniRule annotation
Alternative name(s):
Pantoate--beta-alanine ligaseUniRule annotation
Pantoate-activating enzymeUniRule annotation
Gene namesi
Name:panCUniRule annotation
Ordered Locus Names:Cj0297c
OrganismiCampylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168)
Taxonomic identifieri192222 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeCampylobacter
Proteomesi
  • UP000000799 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001282161 – 282Pantothenate synthetaseAdd BLAST282

Proteomic databases

PaxDbiQ9PIK2.
PRIDEiQ9PIK2.

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

IntActiQ9PIK2. 30 interactors.
STRINGi192222.Cj0297c.

Structurei

Secondary structure

1282
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi2 – 4Combined sources3
Helixi7 – 19Combined sources13
Beta strandi24 – 29Combined sources6
Helixi35 – 44Combined sources10
Beta strandi47 – 54Combined sources8
Helixi58 – 60Combined sources3
Turni67 – 69Combined sources3
Helixi74 – 83Combined sources10
Beta strandi87 – 90Combined sources4
Helixi94 – 97Combined sources4
Beta strandi109 – 111Combined sources3
Helixi115 – 119Combined sources5
Helixi123 – 138Combined sources16
Beta strandi141 – 146Combined sources6
Helixi147 – 149Combined sources3
Helixi150 – 162Combined sources13
Beta strandi166 – 172Combined sources7
Helixi185 – 189Combined sources5
Helixi192 – 213Combined sources22
Helixi219 – 231Combined sources13
Beta strandi236 – 244Combined sources9
Turni246 – 248Combined sources3
Beta strandi259 – 267Combined sources9
Beta strandi270 – 278Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3MXTX-ray1.85A1-282[»]
3UY4X-ray1.85A1-282[»]
ProteinModelPortaliQ9PIK2.
SMRiQ9PIK2.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9PIK2.

Family & Domainsi

Sequence similaritiesi

Belongs to the pantothenate synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107R03. Bacteria.
COG0414. LUCA.
HOGENOMiHOG000175517.
KOiK01918.
OMAiENVDCIF.

Family and domain databases

CDDicd00560. PanC. 1 hit.
Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00158. PanC. 1 hit.
InterProiIPR003721. Pantoate_ligase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERiPTHR21299:SF1. PTHR21299:SF1. 1 hit.
PfamiPF02569. Pantoate_ligase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00018. panC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9PIK2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQVITSVKEA KQIVKDWKSH QLSIGYVPTM GFLHDGHLSL VKHAKTQDKV
60 70 80 90 100
IVSIFVNPMQ FGPNEDFSSY PRDLERDIKM CQDNGVDMVF IPDATQMYLK
110 120 130 140 150
NFSTYVDMNT ITDKLCGAKR PGHFRGVCTV LTKFFNILNP DIVYMGQKDA
160 170 180 190 200
QQCVVVRHMV DDLNFDLKIQ ICPIIREEDG LAKSSRNVYL SKEERKASLA
210 220 230 240 250
ISQSIFLAEK LVREGEKNTS KIIQAMKDIL EKEKLIKIDY IELVDFNTME
260 270 280
NIENITDNVL GAVAAFVGKT RLIDNFLVQG LK
Length:282
Mass (Da):32,087
Last modified:December 1, 2000 - v1
Checksum:iC8946F933D7B6475
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL111168 Genomic DNA. Translation: CAL34448.1.
PIRiE81448.
RefSeqiWP_002778123.1. NC_002163.1.
YP_002343735.1. NC_002163.1.

Genome annotation databases

EnsemblBacteriaiCAL34448; CAL34448; Cj0297c.
GeneIDi904621.
KEGGicje:Cj0297c.
PATRICi20057511. VBICamJej33762_0289.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL111168 Genomic DNA. Translation: CAL34448.1.
PIRiE81448.
RefSeqiWP_002778123.1. NC_002163.1.
YP_002343735.1. NC_002163.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3MXTX-ray1.85A1-282[»]
3UY4X-ray1.85A1-282[»]
ProteinModelPortaliQ9PIK2.
SMRiQ9PIK2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9PIK2. 30 interactors.
STRINGi192222.Cj0297c.

Proteomic databases

PaxDbiQ9PIK2.
PRIDEiQ9PIK2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAL34448; CAL34448; Cj0297c.
GeneIDi904621.
KEGGicje:Cj0297c.
PATRICi20057511. VBICamJej33762_0289.

Phylogenomic databases

eggNOGiENOG4107R03. Bacteria.
COG0414. LUCA.
HOGENOMiHOG000175517.
KOiK01918.
OMAiENVDCIF.

Enzyme and pathway databases

UniPathwayiUPA00028; UER00005.
BioCyciCJEJ192222:GJTS-266-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ9PIK2.

Family and domain databases

CDDicd00560. PanC. 1 hit.
Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00158. PanC. 1 hit.
InterProiIPR003721. Pantoate_ligase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERiPTHR21299:SF1. PTHR21299:SF1. 1 hit.
PfamiPF02569. Pantoate_ligase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00018. panC. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPANC_CAMJE
AccessioniPrimary (citable) accession number: Q9PIK2
Secondary accession number(s): Q0PBL2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: November 2, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

The reaction proceeds by a bi uni uni bi ping pong mechanism.UniRule annotation

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.