SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9PIK2

- PANC_CAMJE

UniProt

Q9PIK2 - PANC_CAMJE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Pantothenate synthetase
Gene
panC, Cj0297c
Organism
Campylobacter jejuni subsp. jejuni serotype O:2 (strain NCTC 11168)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate By similarity.UniRule annotation

Catalytic activityi

ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei37 – 371Proton donor By similarity
Binding sitei60 – 601Beta-alanine By similarity
Binding sitei60 – 601Pantoate By similarity
Binding sitei152 – 1521Pantoate By similarity
Binding sitei175 – 1751ATP; via amide nitrogen and carbonyl oxygen By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi30 – 378ATP By similarity
Nucleotide bindingi146 – 1494ATP By similarity
Nucleotide bindingi183 – 1864ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. pantoate-beta-alanine ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. pantothenate biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Pantothenate biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCJEJ192222:GJTS-274-MONOMER.
UniPathwayiUPA00028; UER00005.

Names & Taxonomyi

Protein namesi
Recommended name:
Pantothenate synthetase (EC:6.3.2.1)
Short name:
PS
Alternative name(s):
Pantoate--beta-alanine ligase
Pantoate-activating enzyme
Gene namesi
Name:panC
Ordered Locus Names:Cj0297c
OrganismiCampylobacter jejuni subsp. jejuni serotype O:2 (strain NCTC 11168)
Taxonomic identifieri192222 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeCampylobacter
ProteomesiUP000000799: Chromosome

Subcellular locationi

Cytoplasm Reviewed prediction UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 282282Pantothenate synthetaseUniRule annotation
PRO_0000128216Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

IntActiQ9PIK2. 30 interactions.
STRINGi192222.Cj0297c.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi2 – 43
Helixi7 – 1913
Beta strandi24 – 296
Helixi35 – 4410
Beta strandi47 – 548
Helixi58 – 603
Turni67 – 693
Helixi74 – 8310
Beta strandi87 – 904
Helixi94 – 974
Beta strandi109 – 1113
Helixi115 – 1195
Helixi123 – 13816
Beta strandi141 – 1466
Helixi147 – 1493
Helixi150 – 16213
Beta strandi166 – 1727
Helixi185 – 1895
Helixi192 – 21322
Helixi219 – 23113
Beta strandi236 – 2449
Turni246 – 2483
Beta strandi259 – 2679
Beta strandi270 – 2789

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3MXTX-ray1.85A1-282[»]
3UY4X-ray1.85A1-282[»]
ProteinModelPortaliQ9PIK2.
SMRiQ9PIK2. Positions 1-278.

Miscellaneous databases

EvolutionaryTraceiQ9PIK2.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0414.
HOGENOMiHOG000175517.
KOiK01918.
OMAiECPIVRE.
OrthoDBiEOG6Z6FZ4.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00158. PanC.
InterProiIPR003721. Pantoate_ligase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERiPTHR21299:SF1. PTHR21299:SF1. 1 hit.
PfamiPF02569. Pantoate_ligase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00018. panC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9PIK2-1 [UniParc]FASTAAdd to Basket

« Hide

MQVITSVKEA KQIVKDWKSH QLSIGYVPTM GFLHDGHLSL VKHAKTQDKV    50
IVSIFVNPMQ FGPNEDFSSY PRDLERDIKM CQDNGVDMVF IPDATQMYLK 100
NFSTYVDMNT ITDKLCGAKR PGHFRGVCTV LTKFFNILNP DIVYMGQKDA 150
QQCVVVRHMV DDLNFDLKIQ ICPIIREEDG LAKSSRNVYL SKEERKASLA 200
ISQSIFLAEK LVREGEKNTS KIIQAMKDIL EKEKLIKIDY IELVDFNTME 250
NIENITDNVL GAVAAFVGKT RLIDNFLVQG LK 282
Length:282
Mass (Da):32,087
Last modified:December 1, 2000 - v1
Checksum:iC8946F933D7B6475
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL111168 Genomic DNA. Translation: CAL34448.1.
PIRiE81448.
RefSeqiYP_002343735.1. NC_002163.1.

Genome annotation databases

EnsemblBacteriaiCAL34448; CAL34448; Cj0297c.
GeneIDi904621.
KEGGicje:Cj0297c.
PATRICi20057511. VBICamJej33762_0289.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL111168 Genomic DNA. Translation: CAL34448.1 .
PIRi E81448.
RefSeqi YP_002343735.1. NC_002163.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3MXT X-ray 1.85 A 1-282 [» ]
3UY4 X-ray 1.85 A 1-282 [» ]
ProteinModelPortali Q9PIK2.
SMRi Q9PIK2. Positions 1-278.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q9PIK2. 30 interactions.
STRINGi 192222.Cj0297c.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAL34448 ; CAL34448 ; Cj0297c .
GeneIDi 904621.
KEGGi cje:Cj0297c.
PATRICi 20057511. VBICamJej33762_0289.

Phylogenomic databases

eggNOGi COG0414.
HOGENOMi HOG000175517.
KOi K01918.
OMAi ECPIVRE.
OrthoDBi EOG6Z6FZ4.

Enzyme and pathway databases

UniPathwayi UPA00028 ; UER00005 .
BioCyci CJEJ192222:GJTS-274-MONOMER.

Miscellaneous databases

EvolutionaryTracei Q9PIK2.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
HAMAPi MF_00158. PanC.
InterProi IPR003721. Pantoate_ligase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
PANTHERi PTHR21299:SF1. PTHR21299:SF1. 1 hit.
Pfami PF02569. Pantoate_ligase. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00018. panC. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NCTC 11168.

Entry informationi

Entry nameiPANC_CAMJE
AccessioniPrimary (citable) accession number: Q9PIK2
Secondary accession number(s): Q0PBL2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: May 14, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

The reaction proceeds by a bi uni uni bi ping pong mechanism By similarity.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi