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Protein

Histidinol-phosphate aminotransferase

Gene

hisC

Organism
Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi: L-histidine biosynthesis

This protein is involved in step 7 of the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation
Proteins known to be involved in the 9 steps of the subpathway in this organism are:
  1. ATP phosphoribosyltransferase (hisG)
  2. Histidine biosynthesis bifunctional protein HisIE (hisI)
  3. Histidine biosynthesis bifunctional protein HisIE (hisI)
  4. 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase (hisA)
  5. Imidazole glycerol phosphate synthase subunit hisF1 (hisF1), Imidazole glycerol phosphate synthase subunit HisH 2 (hisH2), Imidazole glycerol phosphate synthase subunit HisH 1 (hisH1), Putative imidazole glycerol phosphate synthase subunit hisF2 (hisF2)
  6. Histidine biosynthesis bifunctional protein HisB (hisB)
  7. Histidinol-phosphate aminotransferase (hisC)
  8. Histidine biosynthesis bifunctional protein HisB (hisB)
  9. Histidinol dehydrogenase (hisD)
This subpathway is part of the pathway L-histidine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate, the pathway L-histidine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminotransferase, Transferase
Biological processAmino-acid biosynthesis, Histidine biosynthesis
LigandPyridoxal phosphate

Enzyme and pathway databases

BioCyciCJEJ192222:G1G1F-291-MONOMER
UniPathwayiUPA00031; UER00012

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol-phosphate aminotransferaseUniRule annotation (EC:2.6.1.9UniRule annotation)
Alternative name(s):
Imidazole acetol-phosphate transaminaseUniRule annotation
Gene namesi
Name:hisCUniRule annotation
Ordered Locus Names:Cj0317
OrganismiCampylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168)
Taxonomic identifieri192222 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeCampylobacter
Proteomesi
  • UP000000799 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001533401 – 364Histidinol-phosphate aminotransferaseAdd BLAST364

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei226N6-(pyridoxal phosphate)lysineUniRule annotation1

Proteomic databases

PaxDbiQ9PII2

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi192222.Cj0317

Structurei

Secondary structure

1364
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi5 – 9Combined sources5
Helixi19 – 25Combined sources7
Helixi45 – 54Combined sources10
Helixi55 – 57Combined sources3
Helixi67 – 77Combined sources11
Helixi81 – 83Combined sources3
Beta strandi84 – 89Combined sources6
Helixi90 – 101Combined sources12
Beta strandi107 – 110Combined sources4
Helixi117 – 125Combined sources9
Beta strandi128 – 131Combined sources4
Beta strandi133 – 136Combined sources4
Helixi139 – 148Combined sources10
Turni149 – 152Combined sources4
Beta strandi153 – 161Combined sources9
Turni163 – 165Combined sources3
Helixi171 – 179Combined sources9
Beta strandi185 – 190Combined sources6
Helixi194 – 200Combined sources7
Helixi202 – 204Combined sources3
Helixi208 – 214Combined sources7
Beta strandi218 – 223Combined sources6
Turni231 – 233Combined sources3
Beta strandi236 – 240Combined sources5
Helixi242 – 251Combined sources10
Helixi259 – 269Combined sources11
Helixi272 – 295Combined sources24
Beta strandi304 – 311Combined sources8
Beta strandi313 – 315Combined sources3
Helixi317 – 325Combined sources9
Turni326 – 328Combined sources3
Helixi335 – 337Combined sources3
Beta strandi340 – 345Combined sources6
Helixi349 – 363Combined sources15

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3GETX-ray2.01A/B1-364[»]
ProteinModelPortaliQ9PII2
SMRiQ9PII2
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9PII2

Family & Domainsi

Sequence similaritiesi

Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CIH Bacteria
COG0079 LUCA
HOGENOMiHOG000288510
KOiK00817
OMAiHGFLVYR

Family and domain databases

Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
HAMAPiMF_01023 HisC_aminotrans_2, 1 hit
InterProiView protein in InterPro
IPR004839 Aminotransferase_I/II
IPR005861 HisP_aminotrans
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PfamiView protein in Pfam
PF00155 Aminotran_1_2, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
TIGRFAMsiTIGR01141 hisC, 1 hit

Sequencei

Sequence statusi: Complete.

Q9PII2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKFNEFLNNL SNYEPGKDIE VIAKEYGVKE VIKLASNENP FGTPPKAIEC
60 70 80 90 100
LRQNANKAHL YPDDSMIELK STLAQKYKVQ NENIIIGAGS DQVIEFAIHS
110 120 130 140 150
KLNSKNAFLQ AGVTFAMYEI YAKQCGAKCY KTQSITHNLD EFKKLYETHK
160 170 180 190 200
DEIKLIFLCL PNNPLGECLD ASEATEFIKG VNEDCLVVID AAYNEFASFK
210 220 230 240 250
DSKKHLEPCE LIKEFDNVLY LGTFSKLYGL GGLRIGYGIA NANIISAFYK
260 270 280 290 300
LRAPFNVSNL ALKAAVAAMD DDEFTEKTLE NNFSQMELYK EFAKKHNIKI
310 320 330 340 350
IDSYTNFITY FFDEKNSTDL SEKLLKKGII IRNLKSYGLN AIRITIGTSY
360
ENEKFFTEFD KILR
Length:364
Mass (Da):41,368
Last modified:October 1, 2000 - v1
Checksum:iE1CF525EB38804BC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL111168 Genomic DNA Translation: CAL34468.1
PIRiA81451
RefSeqiWP_002858650.1, NC_002163.1
YP_002343755.1, NC_002163.1

Genome annotation databases

EnsemblBacteriaiCAL34468; CAL34468; Cj0317
GeneIDi904641
KEGGicje:Cj0317
PATRICifig|192222.6.peg.309

Similar proteinsi

Entry informationi

Entry nameiHIS8_CAMJE
AccessioniPrimary (citable) accession number: Q9PII2
Secondary accession number(s): Q0PBJ2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2002
Last sequence update: October 1, 2000
Last modified: April 25, 2018
This is version 101 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health