Reviewed, UniProtKB/Swiss-Prot Q9PIH4 (EX7L_CAMJE)

Names and origin

Protein names

Recommended name:
    Exodeoxyribonuclease 7 large subunit
    EC=3.1.11.6
Alternative name(s):
    Exodeoxyribonuclease VII large subunit
      Short name=Exonuclease VII large subunit

Gene names

Name:	xseA
Ordered Locus Names:	Cj0325

Organism

Campylobacter jejuni [Complete proteome] [HAMAP]

Taxonomic identifier

197 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Campylobacteraceae › Campylobacter

Protein attributes

Sequence length	387 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides By similarity.
Catalytic activity	Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-direction to yield nucleoside 5'-phosphates. HAMAP MF_00378
Subunit structure	Heterooligomer composed of large and small subunits By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the xseA family.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Exonuclease Hydrolase Nuclease
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	DNA catabolic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell exodeoxyribonuclease VII complex Inferred from electronic annotation. Source: InterPro
Molecular function	exodeoxyribonuclease VII activity Inferred from electronic annotation. Source: HAMAP nucleic acid binding Inferred from electronic annotation. Source: InterPro protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
fliG	Q0PBJ0	1	EBI-1194027,EBI-1191336

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 387	387	Exodeoxyribonuclease 7 large subunit HAMAP MF_00378		PRO_0000197832

Sequences

	Sequence		Length	Mass (Da)
	Q9PIH4-1 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: 10E3FD7D55FE9FBB	FASTA	387	44,088
	10 20 30 40 50 60 MTPTELNLKA KALLETHFDD IVLSGEISKI TLHGSGHWYF DLKDERSSIA CAMFKGANLK 70 80 90 100 110 120 VGFKPAVGDF LELCGSVSLY PESGRYQFIA TSMKKAGFGD LEAQFLALKE RLQKEGLFDP 130 140 150 160 170 180 RFKKSLPKFP KKVGIITSKT SAALQDMLKL IHQKEYFLAK IYIFDALTQG NNAPFSLIQA 190 200 210 220 230 240 LKKADDMDLD VLIIARGGGS REDLFCFNDE NLAREIFKAK TPIISAIGHE IDYVISDFVA 250 260 270 280 290 300 DFRAPTPSAA IDTLFYSKLD IEQSLDLMEE KLMQLWNYKI QNYENLLLNL SKFFKFNSLP 310 320 330 340 350 360 KIIDEKIKQS HNIEKQLNHL LANQMRYNEL KLDKLQNAYL QHENFFNKSK KFICIRKNGK 370 380 IANLEDLKSD DIVILSSQTS QKEAKIL

References

[1]

"The genome sequence of the food-borne pathogen Campylobacter jejuni reveals hypervariable sequences." Parkhill J., Wren B.W., Mungall K.L., Ketley J.M., Churcher C.M., Basham D., Chillingworth T., Davies R.M., Feltwell T., Holroyd S., Jagels K., Karlyshev A.V., Moule S., Pallen M.J., Penn C.W., Quail M.A., Rajandream M.A., Rutherford K.M. , van Vliet A.H.M., Whitehead S., Barrell B.G. Nature 403:665-668(2000) [PubMed: 10688204] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: NCTC 11168 / Serotype O:2.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AL111168 Genomic DNA. Translation: CAL34476.1.
PIR	A81452.
RefSeq	YP_002343763.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9PIH4. 61 interactions.
Genome annotation databases
GeneID	904649.
GenomeReviews	Gene locus Cj0325 in contig AL111168_GR.
KEGG	cje:Cj0325.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	Q9PIH4. AYLQHEN.
Enzyme and pathway databases
BioCyc	CJEJ192222:CJ0325-MON.
BRENDA	3.1.11.6. 255835.
Family and domain databases
HAMAP	MF_00378. [Tree]
InterPro	IPR003753. Exonuc_VII_L. IPR004365. NA_bd_OB_tRNA-helicase. [Graphical view]
Pfam	PF02601. Exonuc_VII_L. 1 hit. PF01336. tRNA_anti. 1 hit. [Graphical view]
TIGRFAMs	TIGR00237. xseA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

EX7L_CAMJE

Accession

Primary (citable) accession number: Q9PIH4
Secondary accession number(s): Q0PBI4

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 2001
Last sequence update:	October 1, 2000
Last modified:	June 16, 2009
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)