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Protein

Exodeoxyribonuclease 7 large subunit

Gene

xseA

Organism
Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.UniRule annotation

Catalytic activityi

Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-direction to yield nucleoside 5'-phosphates.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionExonuclease, Hydrolase, Nuclease

Enzyme and pathway databases

BioCyciCJEJ192222:G1G1F-299-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Exodeoxyribonuclease 7 large subunitUniRule annotation (EC:3.1.11.6UniRule annotation)
Alternative name(s):
Exodeoxyribonuclease VII large subunitUniRule annotation
Short name:
Exonuclease VII large subunitUniRule annotation
Gene namesi
Name:xseAUniRule annotation
Ordered Locus Names:Cj0325
OrganismiCampylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168)
Taxonomic identifieri192222 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeCampylobacter
Proteomesi
  • UP000000799 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001978321 – 387Exodeoxyribonuclease 7 large subunitAdd BLAST387

Proteomic databases

PaxDbiQ9PIH4

Interactioni

Subunit structurei

Heterooligomer composed of large and small subunits.UniRule annotation

Protein-protein interaction databases

IntActiQ9PIH4, 60 interactors
STRINGi192222.Cj0325

Structurei

3D structure databases

SMRiQ9PIH4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the XseA family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DVS Bacteria
COG1570 LUCA
HOGENOMiHOG000229265
KOiK03601
OMAiFENKHHL

Family and domain databases

CDDicd04489 ExoVII_LU_OBF, 1 hit
HAMAPiMF_00378 Exonuc_7_L, 1 hit
InterProiView protein in InterPro
IPR003753 Exonuc_VII_L
IPR020579 Exonuc_VII_lsu_C
IPR025824 OB-fold_nuc-bd_dom
PANTHERiPTHR30008 PTHR30008, 1 hit
PfamiView protein in Pfam
PF02601 Exonuc_VII_L, 1 hit
PF13742 tRNA_anti_2, 1 hit
TIGRFAMsiTIGR00237 xseA, 1 hit

Sequencei

Sequence statusi: Complete.

Q9PIH4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTPTELNLKA KALLETHFDD IVLSGEISKI TLHGSGHWYF DLKDERSSIA
60 70 80 90 100
CAMFKGANLK VGFKPAVGDF LELCGSVSLY PESGRYQFIA TSMKKAGFGD
110 120 130 140 150
LEAQFLALKE RLQKEGLFDP RFKKSLPKFP KKVGIITSKT SAALQDMLKL
160 170 180 190 200
IHQKEYFLAK IYIFDALTQG NNAPFSLIQA LKKADDMDLD VLIIARGGGS
210 220 230 240 250
REDLFCFNDE NLAREIFKAK TPIISAIGHE IDYVISDFVA DFRAPTPSAA
260 270 280 290 300
IDTLFYSKLD IEQSLDLMEE KLMQLWNYKI QNYENLLLNL SKFFKFNSLP
310 320 330 340 350
KIIDEKIKQS HNIEKQLNHL LANQMRYNEL KLDKLQNAYL QHENFFNKSK
360 370 380
KFICIRKNGK IANLEDLKSD DIVILSSQTS QKEAKIL
Length:387
Mass (Da):44,088
Last modified:October 1, 2000 - v1
Checksum:i10E3FD7D55FE9FBB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL111168 Genomic DNA Translation: CAL34476.1
PIRiA81452
RefSeqiWP_002851089.1, NC_002163.1
YP_002343763.1, NC_002163.1

Genome annotation databases

EnsemblBacteriaiCAL34476; CAL34476; Cj0325
GeneIDi904649
KEGGicje:Cj0325
PATRICifig|192222.6.peg.317

Similar proteinsi

Entry informationi

Entry nameiEX7L_CAMJE
AccessioniPrimary (citable) accession number: Q9PIH4
Secondary accession number(s): Q0PBI4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: October 1, 2000
Last modified: March 28, 2018
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health