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Q9PIH3 (SERC_CAMJE) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Phosphoserine aminotransferase
EC=2.6.1.52
Alternative name(s):
Phosphohydroxythreonine aminotransferase
Short name=PSAT
Gene names
Name:serC
Ordered Locus Names:Cj0326
OrganismCampylobacter jejuni
Taxonomic identifier197 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Campylobacteraceae › Campylobacter

Protein attributes

Sequence length358 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine By similarity. HAMAP MF_00160

Catalytic activity

O-phospho-L-serine + 2-oxoglutarate = 3-phosphonooxypyruvate + L-glutamate. HAMAP MF_00160

4-phosphonooxy-L-threonine + 2-oxoglutarate = (3R)-3-hydroxy-2-oxo-4-phosphonooxybutanoate + L-glutamate. HAMAP MF_00160

Cofactor

Binds 1 pyridoxal phosphate per subunit By similarity. HAMAP MF_00160

Pathway

Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 2/3. HAMAP MF_00160

Cofactor biosynthesis; pyridoxine 5'-phosphate biosynthesis; pyridoxine 5'-phosphate from D-erythrose 4-phosphate: step 3/5. HAMAP MF_00160

Subunit structure

Homodimer By similarity. HAMAP MF_00160

Subcellular location

Cytoplasm By similarity HAMAP MF_00160.

Sequence similarities

Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 358358Phosphoserine aminotransferase HAMAP MF_00160
PRO_0000150161

Regions

Region75 – 762Pyridoxal phosphate binding By similarity
Region233 – 2342Pyridoxal phosphate binding By similarity

Sites

Binding site411L-glutamate By similarity
Binding site1001Pyridoxal phosphate By similarity
Binding site1481Pyridoxal phosphate By similarity
Binding site1671Pyridoxal phosphate By similarity
Binding site1901Pyridoxal phosphate By similarity

Amino acid modifications

Modified residue1911N6-(pyridoxal phosphate)lysine By similarity

Secondary structure

1 ........................................................ 358
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q9PIH3 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: F280E35A5ABB5445

FASTA35840,486
        10         20         30         40         50         60 
MRKINFSAGP STLPLEILEQ AQKELCDYQG RGYSIMEISH RTKVFEEVHF GAQEKAKKLY 

        70         80         90        100        110        120 
ELNDDYEVLF LQGGASLQFA MIPMNLALNG VCEYANTGVW TKKAIKEAQI LGVNVKTVAS 

       130        140        150        160        170        180 
SEESNFDHIP RVEFSDNADY AYICSNNTIY GTQYQNYPKT KTPLIVDASS DFFSRKVDFS 

       190        200        210        220        230        240 
NIALFYGGVQ KNAGISGLSC IFIRKDMLER SKNKQIPSML NYLTHAENQS LFNTPPTFAI 

       250        260        270        280        290        300 
YMFNLEMDWL LNQGGLDKVH EKNSQKATML YECIDLSNGF YKGHADKKDR SLMNVSFNIA 

       310        320        330        340        350 
KNKDLEPLFV KEAEEAGMIG LKGHRILGGI RASIYNALNL DQVKTLCEFM KEFQGKYA

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AL111168 Genomic DNA. Translation: CAL34477.1.
PIRB81452.
RefSeqYP_002343764.1. NC_002163.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3M5UX-ray2.15A/B1-358[»]
ProteinModelPortalQ9PIH3.
ModBaseSearch...

Protein-protein interaction databases

IntActQ9PIH3. 19 interactions.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID904650.
GenomeReviewsGene locus Cj0326 in contig AL111168_GR.
KEGGcje:Cj0326.
PATRIC20057569. VBICamJej33762_0318.

Phylogenomic databases

HOGENOMHBG289982.
OMAYEVLFLQ.
ProtClustDBPRK05355.

Enzyme and pathway databases

BioCycCJEJ192222:CJ0326-MONOMER.

Family and domain databases

HAMAPMF_00160. SerC_aminotrans_5.
[Tree]
InterProIPR000192. Aminotrans_V/Cys_dSase.
IPR022278. Pser_aminoTfrase.
IPR003248. Pser_aminoTfrase_subgr.
IPR015424. PyrdxlP-dep_Trfase_major_dom.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
Gene3DG3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit.
G3DSA:3.90.1150.10. PyrdxlP-dep_Trfase_major_sub2. 1 hit.
KOK00831.
PANTHERPTHR21152:SF1. PTHR21152:SF1. 1 hit.
PfamPF00266. Aminotran_5. 1 hit.
[Graphical view]
PIRSFPIRSF000525. SerC. 1 hit.
SUPFAMSSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
TIGRFAMsTIGR01364. SerC_1. 1 hit.
PROSITEPS00595. AA_TRANSFER_CLASS_5. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSERC_CAMJE
AccessionPrimary (citable) accession number: Q9PIH3
Secondary accession number(s): Q0PBI3
Entry history
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: October 1, 2000
Last modified: January 25, 2012
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

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