Q9PIF2 (TRPB_CAMJE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Tryptophan synthase beta chain
EC=4.2.1.20

Gene names

Name:	trpB
Ordered Locus Names:	Cj0348

Organism

Campylobacter jejuni

Taxonomic identifier

197 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Campylobacteraceae › Campylobacter

Protein attributes

Sequence length	392 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine. HAMAP MF_00133
Catalytic activity	L-serine + 1-C-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + glyceraldehyde 3-phosphate + H2O. HAMAP MF_00133
Cofactor	Pyridoxal phosphate By similarity. HAMAP MF_00133
Pathway	Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5. HAMAP MF_00133
Subunit structure	Tetramer of two alpha and two beta chains By similarity.
Sequence similarities	Belongs to the TrpB family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis Tryptophan biosynthesis
Ligand	Pyridoxal phosphate
Molecular function	Lyase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular function	pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro tryptophan synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 392	392	Tryptophan synthase beta chain HAMAP MF_00133		PRO_0000098934
Amino acid modifications
	Modified residue	84	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9PIF2 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: 3423FB3035C50732	FASTA	392	42,947
	10 20 30 40 50 60 MKKAYYGDFG GQFLPESAMF ALNELEGAFL KFSKDKLFKK ELNELLKTYV GRPTPLYFAR 70 80 90 100 110 120 NLSKKYQHEI YLKREDLNHT GAHKINNAIA QALLAKKMGK KKIIAETGAG QHGLATATAA 130 140 150 160 170 180 ALLGLECEIY MGATDVQRQA LNVYKMELLG AKIHAVQSGL KTLKEATTAA IQAWVGDIKN 190 200 210 220 230 240 IFYVVGSAVG PYPYPKMVMH FQSIIGKECK MQLQKLNKKV DYIIAAVGGG SNAAGIFYDF 250 260 270 280 290 300 IKDENVKLIG IEAGGLGIDT PYHAATLNKG KTGIIHGMKT KVLQDDLGNI LPVHSVSAGL 310 320 330 340 350 360 DYPGIGPLHA FLFESKRAQY HAISDEECMQ ALKLLCKEEG IIAAIESSHA LAFLEKLCPT 370 380 390 LKKKSVIVVN LSGRGDKDMQ MIRDYKKGVI YG

References

[1]

"The genome sequence of the food-borne pathogen Campylobacter jejuni reveals hypervariable sequences." Parkhill J., Wren B.W., Mungall K.L., Ketley J.M., Churcher C.M., Basham D., Chillingworth T., Davies R.M., Feltwell T., Holroyd S., Jagels K., Karlyshev A.V., Moule S., Pallen M.J., Penn C.W., Quail M.A., Rajandream M.A., Rutherford K.M. , van Vliet A.H.M., Whitehead S., Barrell B.G. Nature 403:665-668(2000) [PubMed: 10688204] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: NCTC 11168 / Serotype O:2.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL111168 Genomic DNA. Translation: CAL34499.1.
PIR	C81377.
RefSeq	YP_002343786.1. NC_002163.1.
3D structure databases
ProteinModelPortal	Q9PIF2.
SMR	Q9PIF2. Positions 4-385.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9PIF2. 54 interactions.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	904672.
GenomeReviews	Gene locus Cj0348 in contig AL111168_GR.
KEGG	cje:Cj0348.
PATRIC	20057613. VBICamJej33762_0340.
Phylogenomic databases
HOGENOM	HBG303148.
OMA	LKREDLC.
PhylomeDB	Q9PIF2.
ProtClustDB	PRK04346.
Enzyme and pathway databases
BioCyc	CJEJ192222:CJ0348-MONOMER.
Family and domain databases
HAMAP	MF_00133. Trp_synth_beta. [Tree]
InterPro	IPR001926. PyrdxlP-dep_enz_bsu. IPR006653. Trp_synth_b_CS. IPR006654. Trp_synth_beta. IPR023026. Trp_synth_beta/beta-like. [Graphical view]
KO	K01696.
PANTHER	PTHR10314:SF3. PTHR10314:SF3. 1 hit.
Pfam	PF00291. PALP. 1 hit. [Graphical view]
PIRSF	PIRSF001413. Trp_syn_beta. 1 hit.
SUPFAM	SSF53686. PyrdxlP-dep_enz_bsu. 1 hit.
TIGRFAMs	TIGR00263. TrpB. 1 hit.
PROSITE	PS00168. TRP_SYNTHASE_BETA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TRPB_CAMJE

Accession

Primary (citable) accession number: Q9PIF2
Secondary accession number(s): Q0PBG1

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 19, 2002
Last sequence update:	October 1, 2000
Last modified:	January 25, 2012
This is version 69 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program