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Q9PIF1 (TRPA_CAMJE) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Tryptophan synthase alpha chain
EC=4.2.1.20
Gene names
Name:trpA
Ordered Locus Names:Cj0349
OrganismCampylobacter jejuni
Taxonomic identifier197 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Campylobacteraceae › Campylobacter

Protein attributes

Sequence length249 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. HAMAP MF_00131

Catalytic activity

L-serine + 1-C-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + glyceraldehyde 3-phosphate + H2O. HAMAP MF_00131

Pathway

Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5. HAMAP MF_00131

Subunit structure

Tetramer of two alpha and two beta chains By similarity.

Sequence similarities

Belongs to the TrpA family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 249249Tryptophan synthase alpha chain HAMAP MF_00131
PRO_0000098762

Sites

Active site431Proton acceptor By similarity
Active site541Proton acceptor By similarity

Secondary structure

1 .............................................. 249
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q9PIF1 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: 79FF358CD7CAC987

FASTA24927,967
        10         20         30         40         50         60 
MVDFRKFYKE NANVAYTVLG YPNLQTSEAF LQRLDQSPID ILELGVAYSD PIADGEIIAD 

        70         80         90        100        110        120 
AAKIALDQGV DIHSVFELLA RIKTKKALVF MVYYNLIFSY GLEKFVKKAK SLGICALIVP 

       130        140        150        160        170        180 
ELSFEESDDL IKECERYNIA LITLVSVTTP KERVKKLVKH AKGFIYLLAS IGITGTKSVE 

       190        200        210        220        230        240 
EAILQDKVKE IRSFTNLPIF VGFGIQNNQD VKRMRKVADG VIVGTSIVKC FKQGNLDIIM 


KDIEEIFKK

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AL111168 Genomic DNA. Translation: CAL34500.1.
PIRD81377.
RefSeqYP_002343787.1. NC_002163.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3THAX-ray2.37A/B1-249[»]
ProteinModelPortalQ9PIF1.
ModBaseSearch...

Protein-protein interaction databases

IntActQ9PIF1. 2 interactions.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID904673.
GenomeReviewsGene locus Cj0349 in contig AL111168_GR.
KEGGcje:Cj0349.
PATRIC20057615. VBICamJej33762_0341.

Phylogenomic databases

HOGENOMHBG391690.
OMANPIYIYG.
PhylomeDBQ9PIF1.
ProtClustDBPRK13111.

Enzyme and pathway databases

BioCycCJEJ192222:CJ0349-MONOMER.

Family and domain databases

HAMAPMF_00131. Trp_synth_alpha.
[Tree]
InterProIPR013785. Aldolase_TIM.
IPR011060. RibuloseP-bd_barrel.
IPR018204. Trp_synthase_alpha_AS.
IPR002028. Trp_synthase_suA.
[Graphical view]
Gene3DG3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KOK01695.
PfamPF00290. Trp_syntA. 1 hit.
[Graphical view]
SUPFAMSSF51366. RibP_bind_barrel. 1 hit.
TIGRFAMsTIGR00262. TrpA. 1 hit.
PROSITEPS00167. TRP_SYNTHASE_ALPHA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTRPA_CAMJE
AccessionPrimary (citable) accession number: Q9PIF1
Secondary accession number(s): Q0PBG0
Entry history
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: October 1, 2000
Last modified: January 25, 2012
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

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