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Q9PIC1

- PYRF_CAMJE

UniProt

Q9PIC1 - PYRF_CAMJE

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Protein

Orotidine 5'-phosphate decarboxylase

Gene

pyrF

Organism
Campylobacter jejuni subsp. jejuni serotype O:2 (strain NCTC 11168)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).UniRule annotation

Catalytic activityi

Orotidine 5'-phosphate = UMP + CO2.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei8 – 81SubstrateUniRule annotation
Binding sitei30 – 301SubstrateUniRule annotation
Active sitei60 – 601Proton donorUniRule annotation
Binding sitei117 – 1171SubstrateUniRule annotation
Binding sitei177 – 1771SubstrateUniRule annotation
Binding sitei186 – 1861SubstrateUniRule annotation
Binding sitei206 – 2061Substrate; via amide nitrogenUniRule annotation
Binding sitei207 – 2071SubstrateUniRule annotation

GO - Molecular functioni

  1. orotidine-5'-phosphate decarboxylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
  2. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Pyrimidine biosynthesis

Enzyme and pathway databases

BioCyciCJEJ192222:GJTS-357-MONOMER.
UniPathwayiUPA00070; UER00120.

Names & Taxonomyi

Protein namesi
Recommended name:
Orotidine 5'-phosphate decarboxylaseUniRule annotation (EC:4.1.1.23UniRule annotation)
Alternative name(s):
OMP decarboxylaseUniRule annotation
Short name:
OMPDCaseUniRule annotation
Short name:
OMPdecaseUniRule annotation
Gene namesi
Name:pyrFUniRule annotation
Ordered Locus Names:Cj0381c
OrganismiCampylobacter jejuni subsp. jejuni serotype O:2 (strain NCTC 11168)
Taxonomic identifieri192222 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeCampylobacter
ProteomesiUP000000799: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 279279Orotidine 5'-phosphate decarboxylasePRO_0000134535Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

IntActiQ9PIC1. 23 interactions.
STRINGi192222.Cj0381c.

Structurei

Secondary structure

1
279
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi2 – 65Combined sources
Helixi12 – 2110Combined sources
Turni22 – 243Combined sources
Beta strandi28 – 314Combined sources
Helixi33 – 397Combined sources
Helixi41 – 5010Combined sources
Beta strandi54 – 618Combined sources
Helixi65 – 7612Combined sources
Turni77 – 793Combined sources
Beta strandi81 – 866Combined sources
Helixi87 – 893Combined sources
Helixi91 – 10111Combined sources
Beta strandi104 – 1063Combined sources
Beta strandi109 – 1135Combined sources
Helixi121 – 1288Combined sources
Helixi132 – 14514Combined sources
Beta strandi149 – 1524Combined sources
Turni155 – 1573Combined sources
Helixi158 – 1647Combined sources
Beta strandi169 – 1735Combined sources
Helixi192 – 1976Combined sources
Beta strandi201 – 2055Combined sources
Helixi207 – 2104Combined sources
Helixi215 – 22612Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3RU6X-ray1.80A/B/C/D1-279[»]
ProteinModelPortaliQ9PIC1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni58 – 6710Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the OMP decarboxylase family. Type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0284.
HOGENOMiHOG000226071.
KOiK01591.
OMAiRPITQSA.
OrthoDBiEOG6N6815.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_01200_B. OMPdecase_type1_B.
InterProiIPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTiSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
TIGRFAMsiTIGR01740. pyrF. 1 hit.
PROSITEiPS00156. OMPDECASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9PIC1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKLCVALDLS TKEECLQLAK ELKNLDIWLK VGLRAYLRDG FKFIEELKKV
60 70 80 90 100
DDFKIFLDLK FHDIPNTMAD ACEEVSKLGV DMINIHASAG KIAIQEVMTR
110 120 130 140 150
LSKFSKRPLV LAVSALTSFD EENFFSIYRQ KIEEAVINFS KISYENGLDG
160 170 180 190 200
MVCSVFESKK IKEHTSSNFL TLTPGIRPFG ETNDDQKRVA NLAMARENLS
210 220 230 240 250
DYIVVGRPIY KNENPRAVCE KILNKIHRKN ISENDIEQNY EVIQQKEWDM
260 270
CNHFEEWIKT RPDKEHALKE FYAKCGIKY
Length:279
Mass (Da):32,331
Last modified:October 1, 2000 - v1
Checksum:iC395A4569A7338A8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL111168 Genomic DNA. Translation: CAL34531.1.
PIRiC81381.
RefSeqiYP_002343818.1. NC_002163.1.

Genome annotation databases

EnsemblBacteriaiCAL34531; CAL34531; Cj0381c.
GeneIDi904704.
KEGGicje:Cj0381c.
PATRICi20057677. VBICamJej33762_0372.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL111168 Genomic DNA. Translation: CAL34531.1 .
PIRi C81381.
RefSeqi YP_002343818.1. NC_002163.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3RU6 X-ray 1.80 A/B/C/D 1-279 [» ]
ProteinModelPortali Q9PIC1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q9PIC1. 23 interactions.
STRINGi 192222.Cj0381c.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAL34531 ; CAL34531 ; Cj0381c .
GeneIDi 904704.
KEGGi cje:Cj0381c.
PATRICi 20057677. VBICamJej33762_0372.

Phylogenomic databases

eggNOGi COG0284.
HOGENOMi HOG000226071.
KOi K01591.
OMAi RPITQSA.
OrthoDBi EOG6N6815.

Enzyme and pathway databases

UniPathwayi UPA00070 ; UER00120 .
BioCyci CJEJ192222:GJTS-357-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_01200_B. OMPdecase_type1_B.
InterProi IPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view ]
Pfami PF00215. OMPdecase. 1 hit.
[Graphical view ]
SMARTi SM00934. OMPdecase. 1 hit.
[Graphical view ]
SUPFAMi SSF51366. SSF51366. 1 hit.
TIGRFAMsi TIGR01740. pyrF. 1 hit.
PROSITEi PS00156. OMPDECASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NCTC 11168.

Entry informationi

Entry nameiPYRF_CAMJE
AccessioniPrimary (citable) accession number: Q9PIC1
Secondary accession number(s): Q0PBC9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: October 1, 2000
Last modified: October 29, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3