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Q9PIC1

- PYRF_CAMJE

UniProt

Q9PIC1 - PYRF_CAMJE

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Protein
Orotidine 5'-phosphate decarboxylase
Gene
pyrF, Cj0381c
Organism
Campylobacter jejuni subsp. jejuni serotype O:2 (strain NCTC 11168)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP) By similarity.UniRule annotation

Catalytic activityi

Orotidine 5'-phosphate = UMP + CO2.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei8 – 81Substrate By similarity
Binding sitei30 – 301Substrate By similarity
Active sitei60 – 601Proton donor By similarity
Binding sitei117 – 1171Substrate By similarity
Binding sitei177 – 1771Substrate By similarity
Binding sitei186 – 1861Substrate By similarity
Binding sitei206 – 2061Substrate; via amide nitrogen By similarity
Binding sitei207 – 2071Substrate By similarity

GO - Molecular functioni

  1. orotidine-5'-phosphate decarboxylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway
  2. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Pyrimidine biosynthesis

Enzyme and pathway databases

BioCyciCJEJ192222:GJTS-357-MONOMER.
UniPathwayiUPA00070; UER00120.

Names & Taxonomyi

Protein namesi
Recommended name:
Orotidine 5'-phosphate decarboxylase (EC:4.1.1.23)
Alternative name(s):
OMP decarboxylase
Short name:
OMPDCase
Short name:
OMPdecase
Gene namesi
Name:pyrF
Ordered Locus Names:Cj0381c
OrganismiCampylobacter jejuni subsp. jejuni serotype O:2 (strain NCTC 11168)
Taxonomic identifieri192222 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeCampylobacter
ProteomesiUP000000799: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 279279Orotidine 5'-phosphate decarboxylaseUniRule annotation
PRO_0000134535Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

IntActiQ9PIC1. 23 interactions.
STRINGi192222.Cj0381c.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi2 – 65
Helixi12 – 2110
Turni22 – 243
Beta strandi28 – 314
Helixi33 – 397
Helixi41 – 5010
Beta strandi54 – 618
Helixi65 – 7612
Turni77 – 793
Beta strandi81 – 866
Helixi87 – 893
Helixi91 – 10111
Beta strandi104 – 1063
Beta strandi109 – 1135
Helixi121 – 1288
Helixi132 – 14514
Beta strandi149 – 1524
Turni155 – 1573
Helixi158 – 1647
Beta strandi169 – 1735
Helixi192 – 1976
Beta strandi201 – 2055
Helixi207 – 2104
Helixi215 – 22612

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3RU6X-ray1.80A/B/C/D1-279[»]
ProteinModelPortaliQ9PIC1.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni58 – 6710Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0284.
HOGENOMiHOG000226071.
KOiK01591.
OMAiRPITQSA.
OrthoDBiEOG6N6815.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_01200_B. OMPdecase_type1_B.
InterProiIPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTiSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
TIGRFAMsiTIGR01740. pyrF. 1 hit.
PROSITEiPS00156. OMPDECASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9PIC1-1 [UniParc]FASTAAdd to Basket

« Hide

MKLCVALDLS TKEECLQLAK ELKNLDIWLK VGLRAYLRDG FKFIEELKKV    50
DDFKIFLDLK FHDIPNTMAD ACEEVSKLGV DMINIHASAG KIAIQEVMTR 100
LSKFSKRPLV LAVSALTSFD EENFFSIYRQ KIEEAVINFS KISYENGLDG 150
MVCSVFESKK IKEHTSSNFL TLTPGIRPFG ETNDDQKRVA NLAMARENLS 200
DYIVVGRPIY KNENPRAVCE KILNKIHRKN ISENDIEQNY EVIQQKEWDM 250
CNHFEEWIKT RPDKEHALKE FYAKCGIKY 279
Length:279
Mass (Da):32,331
Last modified:October 1, 2000 - v1
Checksum:iC395A4569A7338A8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL111168 Genomic DNA. Translation: CAL34531.1.
PIRiC81381.
RefSeqiYP_002343818.1. NC_002163.1.

Genome annotation databases

EnsemblBacteriaiCAL34531; CAL34531; Cj0381c.
GeneIDi904704.
KEGGicje:Cj0381c.
PATRICi20057677. VBICamJej33762_0372.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL111168 Genomic DNA. Translation: CAL34531.1 .
PIRi C81381.
RefSeqi YP_002343818.1. NC_002163.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3RU6 X-ray 1.80 A/B/C/D 1-279 [» ]
ProteinModelPortali Q9PIC1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q9PIC1. 23 interactions.
STRINGi 192222.Cj0381c.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAL34531 ; CAL34531 ; Cj0381c .
GeneIDi 904704.
KEGGi cje:Cj0381c.
PATRICi 20057677. VBICamJej33762_0372.

Phylogenomic databases

eggNOGi COG0284.
HOGENOMi HOG000226071.
KOi K01591.
OMAi RPITQSA.
OrthoDBi EOG6N6815.

Enzyme and pathway databases

UniPathwayi UPA00070 ; UER00120 .
BioCyci CJEJ192222:GJTS-357-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_01200_B. OMPdecase_type1_B.
InterProi IPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view ]
Pfami PF00215. OMPdecase. 1 hit.
[Graphical view ]
SMARTi SM00934. OMPdecase. 1 hit.
[Graphical view ]
SUPFAMi SSF51366. SSF51366. 1 hit.
TIGRFAMsi TIGR01740. pyrF. 1 hit.
PROSITEi PS00156. OMPDECASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NCTC 11168.

Entry informationi

Entry nameiPYRF_CAMJE
AccessioniPrimary (citable) accession number: Q9PIC1
Secondary accession number(s): Q0PBC9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: October 1, 2000
Last modified: May 14, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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