Q9PIB8 (KDSA_CAMJE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
2-dehydro-3-deoxyphosphooctonate aldolase
EC=2.5.1.55

Alternative name(s):
3-deoxy-D-manno-octulosonic acid 8-phosphate synthase
KDO-8-phosphate synthase
Short name=KDO 8-P synthase
Short name=KDOPS
Phospho-2-dehydro-3-deoxyoctonate aldolase

Gene names

Name:	kdsA
Ordered Locus Names:	Cj0384c

Organism

Campylobacter jejuni

Taxonomic identifier

197 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Campylobacteraceae › Campylobacter

Protein attributes

Sequence length	271 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Phosphoenolpyruvate + D-arabinose 5-phosphate + H2O = 2-dehydro-3-deoxy-D-octonate 8-phosphate + phosphate. HAMAP MF_00056
Pathway	Carbohydrate biosynthesis; 3-deoxy-D-manno-octulosonate biosynthesis; 3-deoxy-D-manno-octulosonate from D-ribulose 5-phosphate: step 2/3. HAMAP MF_00056 Bacterial outer membrane biogenesis; lipopolysaccharide biosynthesis. HAMAP MF_00056
Subcellular location	Cytoplasm By similarity HAMAP MF_00056.
Sequence similarities	Belongs to the KdsA family.

Ontologies

Keywords
Biological process	Lipopolysaccharide biosynthesis
Cellular component	Cytoplasm
Molecular function	Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	lipopolysaccharide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	3-deoxy-8-phosphooctulonate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 271	271	2-dehydro-3-deoxyphosphooctonate aldolase HAMAP MF_00056		PRO_0000187112

Sequences

	Sequence		Length	Mass (Da)
	Q9PIB8 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: 4A2323A9C7BFCE28	FASTA	271	29,780
	10 20 30 40 50 60 MKKMILIAGP CVIESKDLIF KVAEQLKNFN ENPNIEFYFK SSFDKANRTS INSFRGPGLE 70 80 90 100 110 120 EGLKILQSVK DEFGMKILTD IHESNQANPV SEVADVLQIP AFLCRQTDLL VAAAKTKAKI 130 140 150 160 170 180 NIKKGQFLNP SDIKYSVKKV LQTRGIEDEG YEAAQRNGVF VAERGASFGY GNLVVDMRSL 190 200 210 220 230 240 VIMREFAPVI FDATHSVQMP GAAGGSSGGK SEFVEPLARA AAAVGIDGFF FETHINPCEA 250 260 270 LCDGPNMLNL TRLKNCVNTL LEIQNIIKEN K

References

[1]

"The genome sequence of the food-borne pathogen Campylobacter jejuni reveals hypervariable sequences." Parkhill J., Wren B.W., Mungall K.L., Ketley J.M., Churcher C.M., Basham D., Chillingworth T., Davies R.M., Feltwell T., Holroyd S., Jagels K., Karlyshev A.V., Moule S., Pallen M.J., Penn C.W., Quail M.A., Rajandream M.A., Rutherford K.M. , van Vliet A.H.M., Whitehead S., Barrell B.G. Nature 403:665-668(2000) [PubMed: 10688204] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: NCTC 11168 / Serotype O:2.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL111168 Genomic DNA. Translation: CAL34534.1.
PIR	F81381.
RefSeq	YP_002343821.1. NC_002163.1.
3D structure databases
ProteinModelPortal	Q9PIB8.
SMR	Q9PIB8. Positions 2-268.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9PIB8. 3 interactions.
PTM databases
PhosSite	Q9PIB8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	904707.
GenomeReviews	Gene locus Cj0384c in contig AL111168_GR.
KEGG	cje:Cj0384c.
PATRIC	20057683. VBICamJej33762_0375.
Phylogenomic databases
HOGENOM	HBG575990.
OMA	ESRDHAF.
PhylomeDB	Q9PIB8.
ProtClustDB	PRK05198.
Enzyme and pathway databases
BioCyc	CJEJ192222:CJ0384C-MONOMER.
Family and domain databases
HAMAP	MF_00056. KDO8P_synth. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR006218. DAHP1/KDSA. IPR006269. KDO8P_synthase. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K01627.
PANTHER	PTHR21057:SF2. KDO8P_synthase. 1 hit.
Pfam	PF00793. DAHP_synth_1. 1 hit. [Graphical view]
TIGRFAMs	TIGR01362. KDO8P_synth. 1 hit.
ProtoNet	Search...

Entry information

Entry name

KDSA_CAMJE

Accession

Primary (citable) accession number: Q9PIB8
Secondary accession number(s): Q0PBC6

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 10, 2002
Last sequence update:	October 1, 2000
Last modified:	January 25, 2012
This is version 66 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program