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Q9PIB4

- SYW_CAMJE

UniProt

Q9PIB4 - SYW_CAMJE

Protein

Tryptophan--tRNA ligase

Gene

trpS

Organism
Campylobacter jejuni subsp. jejuni serotype O:2 (strain NCTC 11168)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei192 – 1921ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. tryptophan-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. tryptophanyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciCJEJ192222:GJTS-364-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tryptophan--tRNA ligaseUniRule annotation (EC:6.1.1.2UniRule annotation)
    Alternative name(s):
    Tryptophanyl-tRNA synthetaseUniRule annotation
    Short name:
    TrpRSUniRule annotation
    Gene namesi
    Name:trpSUniRule annotation
    Ordered Locus Names:Cj0388
    OrganismiCampylobacter jejuni subsp. jejuni serotype O:2 (strain NCTC 11168)
    Taxonomic identifieri192222 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeCampylobacter
    ProteomesiUP000000799: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 319319Tryptophan--tRNA ligasePRO_0000136613Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    IntActiQ9PIB4. 3 interactions.
    STRINGi192222.Cj0388.

    Structurei

    Secondary structure

    1
    319
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi3 – 75
    Helixi15 – 206
    Helixi22 – 276
    Turni28 – 314
    Beta strandi35 – 384
    Helixi40 – 434
    Turni44 – 463
    Helixi50 – 6617
    Turni71 – 733
    Beta strandi74 – 785
    Helixi79 – 813
    Helixi84 – 929
    Helixi93 – 953
    Helixi98 – 1025
    Helixi105 – 1128
    Helixi119 – 13416
    Beta strandi138 – 1414
    Helixi144 – 1463
    Helixi147 – 16418
    Beta strandi172 – 1743
    Beta strandi187 – 1893
    Helixi192 – 1943
    Beta strandi199 – 2013
    Helixi204 – 2129
    Helixi227 – 2293
    Helixi231 – 2366
    Helixi237 – 2393
    Helixi242 – 25413
    Helixi259 – 27315
    Helixi275 – 28612
    Helixi288 – 31730

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3M5WX-ray2.32A/B1-319[»]
    3TZLX-ray2.15A/B1-319[»]
    ProteinModelPortaliQ9PIB4.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9PIB4.

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi9 – 179"HIGH" region
    Motifi189 – 1935"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0180.
    HOGENOMiHOG000059939.
    KOiK01867.
    OMAiLELYWIL.
    OrthoDBiEOG686NJQ.

    Family and domain databases

    Gene3Di3.40.50.620. 1 hit.
    HAMAPiMF_00140_B. Trp_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002305. aa-tRNA-synth_Ic.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR002306. Trp-tRNA-ligase.
    IPR024109. Trp-tRNA-ligase_bac-type.
    [Graphical view]
    PANTHERiPTHR10055. PTHR10055. 1 hit.
    PfamiPF00579. tRNA-synt_1b. 1 hit.
    [Graphical view]
    PRINTSiPR01039. TRNASYNTHTRP.
    TIGRFAMsiTIGR00233. trpS. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9PIB4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRVLTGLQPS GDLHIGNYFG AIKQMVDAQE KSQMFMFIAN YHAMTSSQDG    50
    EKLKQNSLKA AAAFLSLGID PQKSVFWLQS DVKEVMELYW ILSQFTPMGL 100
    LERAHSYKDK VAKGLSASHG LFSYPVLMAA DILLFDTRIV PVGKDQIQHV 150
    EIARDIALKV NNEWGEIFTL PEARVNEEVA VVVGTDGAKM SKSYQNTIDI 200
    FSSEKTLKKQ ISSIVTDSTA LEDPKDHENC NIFKIAKLFL DESGQKELQI 250
    RYEKGGEGYG HFKIYLNELV NAYFKEAREK YNELLEKPSH LKEILDFGAT 300
    KARKIAQEKM QKIYEKIGL 319
    Length:319
    Mass (Da):36,084
    Last modified:October 1, 2000 - v1
    Checksum:iCB620B2B67AA6666
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL111168 Genomic DNA. Translation: CAL34538.1.
    PIRiB81382.
    RefSeqiYP_002343825.1. NC_002163.1.

    Genome annotation databases

    EnsemblBacteriaiCAL34538; CAL34538; Cj0388.
    GeneIDi904711.
    KEGGicje:Cj0388.
    PATRICi20057691. VBICamJej33762_0379.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL111168 Genomic DNA. Translation: CAL34538.1 .
    PIRi B81382.
    RefSeqi YP_002343825.1. NC_002163.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3M5W X-ray 2.32 A/B 1-319 [» ]
    3TZL X-ray 2.15 A/B 1-319 [» ]
    ProteinModelPortali Q9PIB4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q9PIB4. 3 interactions.
    STRINGi 192222.Cj0388.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAL34538 ; CAL34538 ; Cj0388 .
    GeneIDi 904711.
    KEGGi cje:Cj0388.
    PATRICi 20057691. VBICamJej33762_0379.

    Phylogenomic databases

    eggNOGi COG0180.
    HOGENOMi HOG000059939.
    KOi K01867.
    OMAi LELYWIL.
    OrthoDBi EOG686NJQ.

    Enzyme and pathway databases

    BioCyci CJEJ192222:GJTS-364-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei Q9PIB4.

    Family and domain databases

    Gene3Di 3.40.50.620. 1 hit.
    HAMAPi MF_00140_B. Trp_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002305. aa-tRNA-synth_Ic.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR002306. Trp-tRNA-ligase.
    IPR024109. Trp-tRNA-ligase_bac-type.
    [Graphical view ]
    PANTHERi PTHR10055. PTHR10055. 1 hit.
    Pfami PF00579. tRNA-synt_1b. 1 hit.
    [Graphical view ]
    PRINTSi PR01039. TRNASYNTHTRP.
    TIGRFAMsi TIGR00233. trpS. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: NCTC 11168.

    Entry informationi

    Entry nameiSYW_CAMJE
    AccessioniPrimary (citable) accession number: Q9PIB4
    Secondary accession number(s): Q0PBC2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 8, 2002
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 80 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3