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Reviewed, UniProtKB/Swiss-Prot Q9PHZ9 (PUR7_CAMJE)

Last modified February 9, 2010. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Phosphoribosylaminoimidazole-succinocarboxamide synthase
    EC=6.3.2.6
Alternative name(s):
    SAICAR synthetase
Gene names
Name: purC
Ordered Locus Names: Cj0512
OrganismCampylobacter jejuni [Complete proteome] [HAMAP]
Taxonomic identifier197 [NCBI]
Taxonomic lineageBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeCampylobacter

Protein attributes

Sequence length236 AA.
Sequence statusComplete.
Protein existenceInferred from homology.

General annotation (Comments)

Catalytic activity

ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate = ADP + phosphate + (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate. HAMAP MF_00137

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2. HAMAP MF_00137

Sequence similarities

Belongs to the SAICAR synthetase family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 236236Phosphoribosylaminoimidazole-succinocarboxamide synthase HAMAP MF_00137
PRO_0000100811

Sequences

Sequence LengthMass (Da)Tools
Q9PHZ9-1 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: C3318EF36917F976

FASTA23626,938
        10         20         30         40         50         60 
MTKKEMLYEG KGKKLFKTDD ENLLISEFKD DLTAFNAEKR GNESGKGALN CKISTEIFHL 

        70         80         90        100        110        120 
LEKNGIKTHL VEIISDTEQV VKKCKIVPIE VIVRNVATGS LTKRLGIKDG TVLPFALVEF 

       130        140        150        160        170        180 
CLKDDALGDP FINDEHCLIL NLVQNEAQIS EIKNMARKIN SILTPFFDNK NLRLIDFKIE 

       190        200        210        220        230 
LGLTKDNELV LADEISPDSC RFWDKFSNEK LDKDRFRQDL GNVKMAYEEV LKRILN 

« Hide

References

[1]"The genome sequence of the food-borne pathogen Campylobacter jejuni reveals hypervariable sequences."
Parkhill J., Wren B.W., Mungall K.L., Ketley J.M., Churcher C.M., Basham D., Chillingworth T., Davies R.M., Feltwell T., Holroyd S., Jagels K., Karlyshev A.V., Moule S., Pallen M.J., Penn C.W., Quail M.A., Rajandream M.A., Rutherford K.M. expand/collapse author list , van Vliet A.H.M., Whitehead S., Barrell B.G.
Nature 403:665-668(2000) [PubMed: 10688204] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: NCTC 11168 / Serotype O:2.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL111168 Genomic DNA. Translation: CAL34659.1.
PIRA81397.
RefSeqYP_002343944.1.

3D structure databases

SMRQ9PHZ9. Positions 2-235.
ModBaseSearch...

Protein-protein interaction databases

IntActQ9PHZ9. 14 interactions.

Genome annotation databases

GeneID904841.
GenomeReviewsGene locus Cj0512 in contig AL111168_GR.
KEGGcje:Cj0512.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG306070.
OMATAFNAQK.

Enzyme and pathway databases

BioCycCJEJ192222:CJ0512-MONOMER.
BRENDA6.3.2.6. 255835.

Family and domain databases

HAMAPMF_00137. SAICAR_synth.
[Tree]
InterProIPR013816. ATP_grasp_subdomain_2.
IPR001636. SAICAR_synt.
IPR018236. SAICAR_synthetase_CS.
[Graphical view]
Gene3DG3DSA:3.30.470.20. ATP_grasp_subdomain_2. 1 hit.
PANTHERPTHR11609. SAICAR_synt. 1 hit.
PfamPF01259. SAICAR_synt. 1 hit.
[Graphical view]
TIGRFAMsTIGR00081. purC. 1 hit.
PROSITEPS01057. SAICAR_SYNTHETASE_1. 1 hit.
PS01058. SAICAR_SYNTHETASE_2. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePUR7_CAMJE
AccessionPrimary (citable) accession number: Q9PHZ9
Secondary accession number(s): Q0PB03
Entry history
Integrated into UniProtKB/Swiss-Prot: July 26, 2002
Last sequence update: October 1, 2000
Last modified: February 9, 2010
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents