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Protein

Probable malate dehydrogenase

Gene

mdh

Organism
Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate.By similarity

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei81SubstrateBy similarity1
Binding sitei87SubstrateBy similarity1
Binding sitei94NADBy similarity1
Binding sitei119SubstrateBy similarity1
Binding sitei150SubstrateBy similarity1
Active sitei174Proton acceptorBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi6 – 12NADBy similarity7
Nucleotide bindingi117 – 119NADBy similarity3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processTricarboxylic acid cycle
LigandNAD

Enzyme and pathway databases

BioCyciCJEJ192222:G1G1F-509-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Probable malate dehydrogenaseCurated (EC:1.1.1.37By similarity)
Gene namesi
Name:mdh
Ordered Locus Names:Cj0532
OrganismiCampylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168)
Taxonomic identifieri192222 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeCampylobacter
Proteomesi
  • UP000000799 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001134451 – 300Probable malate dehydrogenaseAdd BLAST300

Proteomic databases

PaxDbiQ9PHY2

Interactioni

Protein-protein interaction databases

IntActiQ9PHY2 1 interactor.
STRINGi192222.Cj0532

Structurei

3D structure databases

ProteinModelPortaliQ9PHY2
SMRiQ9PHY2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily.Curated

Phylogenomic databases

eggNOGiENOG4105C80 Bacteria
COG0039 LUCA
HOGENOMiHOG000213794
KOiK00024
OMAiQCTPKVE

Family and domain databases

Gene3Di3.90.110.101 hit
InterProiView protein in InterPro
IPR001557 L-lactate/malate_DH
IPR022383 Lactate/malate_DH_C
IPR001236 Lactate/malate_DH_N
IPR015955 Lactate_DH/Glyco_Ohase_4_C
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF02866 Ldh_1_C, 1 hit
PF00056 Ldh_1_N, 1 hit
PIRSFiPIRSF000102 Lac_mal_DH, 1 hit
PRINTSiPR00086 LLDHDRGNASE
SUPFAMiSSF51735 SSF51735, 1 hit
SSF56327 SSF56327, 1 hit

Sequencei

Sequence statusi: Complete.

Q9PHY2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKITVIGAGN VGSSVAYALI LREIANEIVL VDINEDLLYA KELELTQSIA
60 70 80 90 100
ALNLNIDLLC TKDYTHTKNS DIVLFSAGFA RKDGQSREEL LQLNTSIMLD
110 120 130 140 150
CAKKIKDFTE DPLFIILTNP VDFLLNTLYE SGIFSSKKII AMAGVLDNAR
160 170 180 190 200
FKYELAKKLN VKMSRVDTRL IGFHNDDMVL VKSYASVKNK NISEFLNEEE
210 220 230 240 250
FEDLENEVKT GGAKVIKHLK TSAYLAPASA CIRMLESIRS GEFLPMSVIL
260 270 280 290 300
HGEFGVQNKA LGVMARLGLE GVIEIMKMDL SLQEKDKLEK SLIKYQYKGE
Length:300
Mass (Da):33,513
Last modified:October 1, 2000 - v1
Checksum:i45DABA8AAA648A9A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL111168 Genomic DNA Translation: CAL34678.1
PIRiD81399
RefSeqiWP_002858544.1, NC_002163.1
YP_002343963.1, NC_002163.1

Genome annotation databases

EnsemblBacteriaiCAL34678; CAL34678; Cj0532
GeneIDi904860
KEGGicje:Cj0532
PATRICifig|192222.6.peg.524

Similar proteinsi

Entry informationi

Entry nameiMDH_CAMJE
AccessioniPrimary (citable) accession number: Q9PHY2
Secondary accession number(s): Q0PAY4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: October 1, 2000
Last modified: March 28, 2018
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome