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Q9PHY2

- MDH_CAMJE

UniProt

Q9PHY2 - MDH_CAMJE

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Protein

Probable malate dehydrogenase

Gene

mdh

Organism
Campylobacter jejuni subsp. jejuni serotype O:2 (strain NCTC 11168)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate.By similarity

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei32 – 321NADBy similarity
Binding sitei81 – 811SubstrateBy similarity
Binding sitei87 – 871SubstrateBy similarity
Binding sitei94 – 941NADBy similarity
Binding sitei119 – 1191SubstrateBy similarity
Binding sitei150 – 1501SubstrateBy similarity
Active sitei174 – 1741Proton acceptorBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi7 – 126NADBy similarity
Nucleotide bindingi117 – 1193NADBy similarity

GO - Molecular functioni

  1. L-malate dehydrogenase activity Source: UniProtKB-EC

GO - Biological processi

  1. cellular carbohydrate metabolic process Source: InterPro
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Tricarboxylic acid cycle

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciCJEJ192222:GJTS-516-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable malate dehydrogenase (EC:1.1.1.37)
Gene namesi
Name:mdh
Ordered Locus Names:Cj0532
OrganismiCampylobacter jejuni subsp. jejuni serotype O:2 (strain NCTC 11168)
Taxonomic identifieri192222 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeCampylobacter
ProteomesiUP000000799: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 300300Probable malate dehydrogenasePRO_0000113445Add
BLAST

Interactioni

Protein-protein interaction databases

IntActiQ9PHY2. 1 interaction.
STRINGi192222.Cj0532.

Structurei

3D structure databases

ProteinModelPortaliQ9PHY2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. MDH type 3 family.Curated

Phylogenomic databases

eggNOGiCOG0039.
HOGENOMiHOG000213794.
KOiK00024.
OMAiYGQNDIC.
OrthoDBiEOG6091FG.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
InterProiIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11540. PTHR11540. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSiPR00086. LLDHDRGNASE.
SUPFAMiSSF56327. SSF56327. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9PHY2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKITVIGAGN VGSSVAYALI LREIANEIVL VDINEDLLYA KELELTQSIA
60 70 80 90 100
ALNLNIDLLC TKDYTHTKNS DIVLFSAGFA RKDGQSREEL LQLNTSIMLD
110 120 130 140 150
CAKKIKDFTE DPLFIILTNP VDFLLNTLYE SGIFSSKKII AMAGVLDNAR
160 170 180 190 200
FKYELAKKLN VKMSRVDTRL IGFHNDDMVL VKSYASVKNK NISEFLNEEE
210 220 230 240 250
FEDLENEVKT GGAKVIKHLK TSAYLAPASA CIRMLESIRS GEFLPMSVIL
260 270 280 290 300
HGEFGVQNKA LGVMARLGLE GVIEIMKMDL SLQEKDKLEK SLIKYQYKGE
Length:300
Mass (Da):33,513
Last modified:October 1, 2000 - v1
Checksum:i45DABA8AAA648A9A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL111168 Genomic DNA. Translation: CAL34678.1.
PIRiD81399.
RefSeqiYP_002343963.1. NC_002163.1.

Genome annotation databases

EnsemblBacteriaiCAL34678; CAL34678; Cj0532.
GeneIDi904860.
KEGGicje:Cj0532.
PATRICi20058004. VBICamJej33762_0524.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL111168 Genomic DNA. Translation: CAL34678.1 .
PIRi D81399.
RefSeqi YP_002343963.1. NC_002163.1.

3D structure databases

ProteinModelPortali Q9PHY2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q9PHY2. 1 interaction.
STRINGi 192222.Cj0532.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAL34678 ; CAL34678 ; Cj0532 .
GeneIDi 904860.
KEGGi cje:Cj0532.
PATRICi 20058004. VBICamJej33762_0524.

Phylogenomic databases

eggNOGi COG0039.
HOGENOMi HOG000213794.
KOi K00024.
OMAi YGQNDIC.
OrthoDBi EOG6091FG.

Enzyme and pathway databases

BioCyci CJEJ192222:GJTS-516-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
InterProi IPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR11540. PTHR11540. 1 hit.
Pfami PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000102. Lac_mal_DH. 1 hit.
PRINTSi PR00086. LLDHDRGNASE.
SUPFAMi SSF56327. SSF56327. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NCTC 11168.

Entry informationi

Entry nameiMDH_CAMJE
AccessioniPrimary (citable) accession number: Q9PHY2
Secondary accession number(s): Q0PAY4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: October 1, 2000
Last modified: October 1, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3