Reviewed, UniProtKB/Swiss-Prot Q9PHT5 (RPPH_CAMJE)

Names and origin

Protein names

Recommended name:
    RNA pyrophosphohydrolase
    EC=3.6.1.-
Alternative name(s):
    (Di)nucleoside polyphosphate hydrolase

Gene names

Name:	rppH
Synonyms:	nudH
Ordered Locus Names:	Cj0581

Organism

Campylobacter jejuni [Complete proteome] [HAMAP]

Taxonomic identifier

197 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Campylobacteraceae › Campylobacter

Protein attributes

Sequence length	156 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage By similarity.
Cofactor	Divalent ions By similarity.
Sequence similarities	Belongs to the Nudix hydrolase family. RppH subfamily.

Ontologies

Keywords
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides Inferred from electronic annotation. Source: HAMAP protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
fliG	Q0PBJ0	1	EBI-1193504,EBI-1191336

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 156	156	RNA pyrophosphohydrolase HAMAP MF_00298		PRO_0000057000
Regions
	Motif	43 – 64	22	Nudix box HAMAP MF_00298

Sequences

	Sequence		Length	Mass (Da)
	Q9PHT5-1 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: F6E4896B53D8A638	FASTA	156	18,584
	10 20 30 40 50 60 MENEKNYRPN VAAIVLSSSY PFECKIFIAR RSDMDNIWQF PQGGIDKGES VKNALFRELK 70 80 90 100 110 120 EEIGTDEVEI IAEYPEWLSY DFPSKIVKKM YPYDGQIQKY FLVRLKHGAT ININTKHPEF 130 140 150 DDYQFVSVKQ IFEMINHFKK NIYVRVIKYF EEKGYI

References

[1]

"The genome sequence of the food-borne pathogen Campylobacter jejuni reveals hypervariable sequences." Parkhill J., Wren B.W., Mungall K.L., Ketley J.M., Churcher C.M., Basham D., Chillingworth T., Davies R.M., Feltwell T., Holroyd S., Jagels K., Karlyshev A.V., Moule S., Pallen M.J., Penn C.W., Quail M.A., Rajandream M.A., Rutherford K.M. , van Vliet A.H.M., Whitehead S., Barrell B.G. Nature 403:665-668(2000) [PubMed: 10688204] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: NCTC 11168 / Serotype O:2.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AL111168 Genomic DNA. Translation: CAL34727.1.
PIR	D81405.
RefSeq	YP_002344011.1.
3D structure databases
HSSP	HSSP built from PDB template 1F3Y based on UniProtKB O04841.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9PHT5. 6 interactions.
Genome annotation databases
GeneID	905255.
GenomeReviews	Gene locus Cj0581 in contig AL111168_GR.
KEGG	cje:Cj0581.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	Q9PHT5. WIAYDFP.
Enzyme and pathway databases
BioCyc	CJEJ192222:CJ0581-MON.
Family and domain databases
HAMAP	MF_00298. [Tree]
InterPro	IPR000086. NUDIX_hydrolase_core. [Graphical view]
Gene3D	G3DSA:3.90.79.10. NUDIX_hydrolase. 1 hit.
Pfam	PF00293. NUDIX. 1 hit. [Graphical view]
PROSITE	PS00893. NUDIX. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

RPPH_CAMJE

Accession

Primary (citable) accession number: Q9PHT5
Secondary accession number(s): Q0PAT6

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 11, 2001
Last sequence update:	October 1, 2000
Last modified:	June 16, 2009
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)