Reviewed,
UniProtKB/Swiss-Prot Q9PHN5 (ILVC_CAMJE)
Last modified
June 16, 2009.
Version 55.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Ketol-acid reductoisomerase EC=1.1.1.86 Alternative name(s): Acetohydroxy-acid isomeroreductase Alpha-keto-beta-hydroxylacil reductoisomerase | ||||
| Gene names |
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| Organism | Campylobacter jejuni [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 197 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Campylobacteraceae › Campylobacter |
Protein attributes
| Sequence length | 340 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Catalytic activity | (R)-2,3-dihydroxy-3-methylbutanoate + NADP+ = (S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH. HAMAP MF_00435 (2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP+ = (S)-2-hydroxy-2-ethyl-3-oxobutanoate + NADPH. HAMAP MF_00435 |
| Pathway | Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 2/4. HAMAP MF_00435 Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 2/4. HAMAP MF_00435 |
| Sequence similarities | Belongs to the ketol-acid reductoisomerase family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Amino-acid biosynthesis Branched-chain amino acid biosynthesis |
| Ligand | NADP |
| Molecular function | Oxidoreductase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | isoleucine biosynthetic process Inferred from electronic annotation. Source: HAMAP oxidation reductionInferred from electronic annotation. Source: UniProtKB-KW valine biosynthetic processInferred from electronic annotation. Source: HAMAP |
| Molecular function | ketol-acid reductoisomerase activity Inferred from electronic annotation. Source: HAMAP protein bindingInferred from physical interaction. Source: IntAct |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 340 | 340 | Ketol-acid reductoisomerase HAMAP MF_00435 | PRO_0000151297 | |||||
Sites | |||||||||
| Active site | 109 | 1 | Potential | ||||||
Sequences
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References
| [1] | "The genome sequence of the food-borne pathogen Campylobacter jejuni reveals hypervariable sequences." Parkhill J., Wren B.W., Mungall K.L., Ketley J.M., Churcher C.M., Basham D., Chillingworth T., Davies R.M., Feltwell T., Holroyd S., Jagels K., Karlyshev A.V., Moule S., Pallen M.J., Penn C.W., Quail M.A., Rajandream M.A., Rutherford K.M. Barrell B.G.Nature 403:665-668(2000) [PubMed: 10688204] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: NCTC 11168 / Serotype O:2. |
Cross-references
Sequence databases | |
|---|---|
| AL111168 Genomic DNA. Translation: CAL34777.1. | |
| PIR | G81411. |
| RefSeq | YP_002344061.1. |
3D structure databases | |
| HSSP | HSSP built from PDB template 1NP3 based on UniProtKB Q9HVA2. |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | Q9PHN5. 42 interactions. |
PTM databases | |
| PhosSite | Q9PHN5. |
Genome annotation databases | |
| GeneID | 904961. |
| GenomeReviews | Gene locus Cj0632 in contig AL111168_GR. |
| KEGG | cje:Cj0632. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| OMA | Q9PHN5. AHGFNIR. |
Enzyme and pathway databases | |
| BioCyc | CJEJ192222:CJ0632-MON. |
| BRENDA | 1.1.1.86. 255835. |
Family and domain databases | |
| HAMAP | MF_00435. [Tree] |
| InterPro | IPR013023. AcH_isomrdctse. IPR000506. AcH_isomrdctse_C. IPR013116. IlvN. IPR016040. NAD(P)-bd_dom. [Graphical view] |
| Gene3D | G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. |
| PANTHER | PTHR21371. AcH_isomrdctse. 1 hit. |
| Pfam | PF01450. IlvC. 1 hit. PF07991. IlvN. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR00465. ilvC. 1 hit. |
| ProtoNet | Search... |
Entry information
| Entry name | ILVC_CAMJE | ||||||||
| Accession | Primary (citable) accession number: Q9PHN5 Secondary accession number(s): Q0PAN6 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


