Q9PHN0 (MSRA_CAMJE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Peptide methionine sulfoxide reductase MsrA
Short name=Protein-methionine-S-oxide reductase
EC=1.8.4.11

Alternative name(s):
Peptide-methionine (S)-S-oxide reductase
Short name=Peptide Met(O) reductase

Gene names

Name:	mrsA
Ordered Locus Names:	Cj0637c

Organism

Campylobacter jejuni

Taxonomic identifier

197 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Campylobacteraceae › Campylobacter

Protein attributes

Sequence length	165 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine By similarity. HAMAP MF_01401
Catalytic activity	Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin. HAMAP MF_01401 L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin. HAMAP MF_01401
Sequence similarities	Belongs to the MsrA Met sulfoxide reductase family.

Ontologies

Keywords
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	protein metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	peptide-methionine-(S)-S-oxide reductase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
flgK	Q0P8E9	1	EBI-1191927,EBI-1191246

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 165	165	Peptide methionine sulfoxide reductase MsrA HAMAP MF_01401		PRO_0000138534
Sites
	Active site	10	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9PHN0 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: 8DF4366859BF4F13	FASTA	165	18,896
	10 20 30 40 50 60 MKNIVLGGGC FWCVEAVFER LKGVINTEVG YSGGKPNPSY ESVCNGDGNI EVVKINYDEK 70 80 90 100 110 120 QISLLEILTL FFKIHDPTSI DKQGGDIGIQ YRSIIFYENE EDKILAQNFI EEQQKIFSKK 130 140 150 160 IVTKISRLQT YYKAENYHQH YFINNPDQGY CQAVIAPKLQ KIQSD

References

[1]

"The genome sequence of the food-borne pathogen Campylobacter jejuni reveals hypervariable sequences." Parkhill J., Wren B.W., Mungall K.L., Ketley J.M., Churcher C.M., Basham D., Chillingworth T., Davies R.M., Feltwell T., Holroyd S., Jagels K., Karlyshev A.V., Moule S., Pallen M.J., Penn C.W., Quail M.A., Rajandream M.A., Rutherford K.M. , van Vliet A.H.M., Whitehead S., Barrell B.G. Nature 403:665-668(2000) [PubMed: 10688204] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: NCTC 11168 / Serotype O:2.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL111168 Genomic DNA. Translation: CAL34782.1.
PIR	D81412.
RefSeq	YP_002344066.1. NC_002163.1.
3D structure databases
ProteinModelPortal	Q9PHN0.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9PHN0. 84 interactions.
MINT	MINT-6484438.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	904967.
GenomeReviews	Gene locus Cj0637c in contig AL111168_GR.
KEGG	cje:Cj0637c.
PATRIC	20058219. VBICamJej33762_0629.
Phylogenomic databases
HOGENOM	HBG748152.
OMA	IDTEVGY.
ProtClustDB	PRK14054.
Enzyme and pathway databases
BioCyc	CJEJ192222:CJ0637C-MONOMER.
Family and domain databases
HAMAP	MF_01401. MsrA. [Tree]
InterPro	IPR002569. Peptide_Met_Sox_Rdtase_MsrA. [Graphical view]
Gene3D	G3DSA:3.30.1060.10. MsrA. 1 hit.
KO	K07304.
Pfam	PF01625. PMSR. 1 hit. [Graphical view]
SUPFAM	SSF55068. MsrA. 1 hit.
TIGRFAMs	TIGR00401. MsrA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MSRA_CAMJE

Accession

Primary (citable) accession number: Q9PHN0
Secondary accession number(s): Q0PAN1

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 2, 2002
Last sequence update:	October 1, 2000
Last modified:	January 25, 2012
This is version 63 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program