Q9PHM9 (IPYR_CAMJE) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 59.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Inorganic pyrophosphatase EC=3.6.1.1 Alternative name(s): Pyrophosphate phospho-hydrolase Short name=PPase | ||||
| Gene names |
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| Organism | Campylobacter jejuni | ||||
| Taxonomic identifier | 197 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Campylobacteraceae › Campylobacter |
Protein attributes
| Sequence length | 172 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Catalytic activity | Diphosphate + H2O = 2 phosphate. HAMAP MF_00209 |
| Cofactor | Binds 4 magnesium ions per subunit. Other metal ions can support activity, but at a lower rate. Two magnesium ions are required for the activation of the enzyme and are present before substrate binds, two additional magnesium ions form complexes with substrate and product By similarity. |
| Subcellular location | Cytoplasm By similarity HAMAP MF_00209. |
| Sequence similarities | Belongs to the PPase family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Cytoplasm |
| Ligand | Magnesium Metal-binding |
| Molecular function | Hydrolase |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological process | phosphate-containing compound metabolic process Inferred from electronic annotation. Source: InterPro |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | inorganic diphosphatase activity Inferred from electronic annotation. Source: EC magnesium ion bindingInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 172 | 172 | Inorganic pyrophosphatase HAMAP MF_00209 | PRO_0000137487 | |||||
Sites | |||||||||
| Metal binding | 64 | 1 | Magnesium 1 By similarity | ||||||
| Metal binding | 69 | 1 | Magnesium 1 By similarity | ||||||
| Metal binding | 69 | 1 | Magnesium 2 By similarity | ||||||
| Metal binding | 101 | 1 | Magnesium 1 By similarity | ||||||
Sequences
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References
| [1] | "The genome sequence of the food-borne pathogen Campylobacter jejuni reveals hypervariable sequences." Parkhill J., Wren B.W., Mungall K.L., Ketley J.M., Churcher C.M., Basham D., Chillingworth T., Davies R.M., Feltwell T., Holroyd S., Jagels K., Karlyshev A.V., Moule S., Pallen M.J., Penn C.W., Quail M.A., Rajandream M.A., Rutherford K.M. Barrell B.G.Nature 403:665-668(2000) [PubMed: 10688204] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: NCTC 11168 / Serotype O:2. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AL111168 Genomic DNA. Translation: CAL34783.1. |
| PIR | E81412. |
| RefSeq | YP_002344067.1. NC_002163.1. |
3D structure databases | |
| ProteinModelPortal | Q9PHM9. |
| SMR | Q9PHM9. Positions 18-172. |
| ModBase | Search... |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| GeneID | 904968. |
| GenomeReviews | Gene locus Cj0638c in contig AL111168_GR. |
| KEGG | cje:Cj0638c. |
| PATRIC | 20058221. VBICamJej33762_0630. |
Phylogenomic databases | |
| HOGENOM | HBG529150. |
| OMA | PNDFNVI. |
| ProtClustDB | CLSK872397. |
Enzyme and pathway databases | |
| BioCyc | CJEJ192222:CJ0638C-MONOMER. |
Family and domain databases | |
| HAMAP | MF_00209. Inorganic_PPase. [Tree] |
| InterPro | IPR008162. Pyrophosphatase. [Graphical view] |
| Gene3D | G3DSA:3.90.80.10. Pyrophosphatase. 1 hit. |
| KO | K01507. |
| PANTHER | PTHR10286. Pyrophosphatase. 1 hit. |
| Pfam | PF00719. Pyrophosphatase. 1 hit. [Graphical view] |
| SUPFAM | SSF50324. Pyrophosphatase. 1 hit. |
| PROSITE | PS00387. PPASE. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | IPYR_CAMJE | ||||||||
| Accession | Primary (citable) accession number: Q9PHM9 Secondary accession number(s): Q0PAN0 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| SIMILARITY comments Index of protein domains and families |

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