Reviewed,
UniProtKB/Swiss-Prot Q9PHM9 (IPYR_CAMJE)
Last modified
January 19, 2010.
Version 51.
History...
Clusters with 100%,
90%,
50% identity |
Documents (1) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Inorganic pyrophosphatase EC=3.6.1.1 Alternative name(s): Pyrophosphate phospho-hydrolase Short name=PPase | ||||
| Gene names |
| ||||
| Organism | Campylobacter jejuni [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 197 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Campylobacteraceae › Campylobacter |
Protein attributes
| Sequence length | 172 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Catalytic activity | Diphosphate + H2O = 2 phosphate. HAMAP MF_00209 |
| Cofactor | Binds 4 magnesium ions per subunit. Other metal ions can support activity, but at a lower rate. Two magnesium ions are required for the activation of the enzyme and are present before substrate binds, two additional magnesium ions form complexes with substrate and product By similarity. HAMAP MF_00209 |
| Subcellular location | Cytoplasm By similarity HAMAP MF_00209. |
| Sequence similarities | Belongs to the PPase family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Cytoplasm |
| Ligand | Magnesium Metal-binding |
| Molecular function | Hydrolase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | phosphate metabolic process Inferred from electronic annotation. Source: InterPro |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | inorganic diphosphatase activity Inferred from electronic annotation. Source: HAMAP magnesium ion bindingInferred from electronic annotation. Source: HAMAP |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 172 | 172 | Inorganic pyrophosphatase HAMAP MF_00209 | PRO_0000137487 | |||||
Sites | |||||||||
| Metal binding | 64 | 1 | Magnesium 1 By similarity | ||||||
| Metal binding | 69 | 1 | Magnesium 1 By similarity | ||||||
| Metal binding | 69 | 1 | Magnesium 2 By similarity | ||||||
| Metal binding | 101 | 1 | Magnesium 1 By similarity | ||||||
Sequences
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References
| [1] | "The genome sequence of the food-borne pathogen Campylobacter jejuni reveals hypervariable sequences." Parkhill J., Wren B.W., Mungall K.L., Ketley J.M., Churcher C.M., Basham D., Chillingworth T., Davies R.M., Feltwell T., Holroyd S., Jagels K., Karlyshev A.V., Moule S., Pallen M.J., Penn C.W., Quail M.A., Rajandream M.A., Rutherford K.M. Barrell B.G.Nature 403:665-668(2000) [PubMed: 10688204] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: NCTC 11168 / Serotype O:2. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AL111168 Genomic DNA. Translation: CAL34783.1. |
| PIR | E81412. |
| RefSeq | YP_002344067.1. |
3D structure databases | |
| SMR | Q9PHM9. Positions 18-172. |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 904968. |
| GenomeReviews | Gene locus Cj0638c in contig AL111168_GR. |
| KEGG | cje:Cj0638c. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | HBG529150. |
| OMA | EHFFEHY. |
Enzyme and pathway databases | |
| BioCyc | CJEJ192222:CJ0638C-MONOMER. |
| BRENDA | 3.6.1.1. 255835. |
Family and domain databases | |
| HAMAP | MF_00209. Inorganic_PPase. [Tree] |
| InterPro | IPR008162. Pyrophosphatase. [Graphical view] |
| Gene3D | G3DSA:3.90.80.10. Pyrophosphatase. 1 hit. |
| PANTHER | PTHR10286. Pyrophosphatase. 1 hit. |
| Pfam | PF00719. Pyrophosphatase. 1 hit. [Graphical view] |
| PROSITE | PS00387. PPASE. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | IPYR_CAMJE | ||||||||
| Accession | Primary (citable) accession number: Q9PHM9 Secondary accession number(s): Q0PAN0 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||

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