Q9PHM9 (IPYR_CAMJE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Inorganic pyrophosphatase
EC=3.6.1.1

Alternative name(s):
Pyrophosphate phospho-hydrolase
Short name=PPase

Gene names

Name:	ppa
Ordered Locus Names:	Cj0638c

Organism

Campylobacter jejuni

Taxonomic identifier

197 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Campylobacteraceae › Campylobacter

Protein attributes

Sequence length	172 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Diphosphate + H2O = 2 phosphate. HAMAP MF_00209
Cofactor	Binds 4 magnesium ions per subunit. Other metal ions can support activity, but at a lower rate. Two magnesium ions are required for the activation of the enzyme and are present before substrate binds, two additional magnesium ions form complexes with substrate and product By similarity.
Subcellular location	Cytoplasm By similarity HAMAP MF_00209.
Sequence similarities	Belongs to the PPase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	Magnesium Metal-binding
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	phosphate-containing compound metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	inorganic diphosphatase activity Inferred from electronic annotation. Source: EC magnesium ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 172	172	Inorganic pyrophosphatase HAMAP MF_00209		PRO_0000137487
Sites
	Metal binding	64	1	Magnesium 1 By similarity
	Metal binding	69	1	Magnesium 1 By similarity
	Metal binding	69	1	Magnesium 2 By similarity
	Metal binding	101	1	Magnesium 1 By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9PHM9 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: B6055B6D44D1B017	FASTA	172	19,334
	10 20 30 40 50 60 MNLSKIKIGD IPNKINAVIE IPYGSNIKYE IDKDSGAIMV DRVMASAIFY PANYGFIANT 70 80 90 100 110 120 LADDGDPVDI LVLNEYPIQA GAVIPCRLIG VLIMEDESGM DEKLLAVPNS KIDARYDNIK 130 140 150 160 170 TYTDLPQATL NKIKNFFETY KILEPNKWVK VQDFKDEKAA IEILEKAIKN YK

References

[1]

"The genome sequence of the food-borne pathogen Campylobacter jejuni reveals hypervariable sequences." Parkhill J., Wren B.W., Mungall K.L., Ketley J.M., Churcher C.M., Basham D., Chillingworth T., Davies R.M., Feltwell T., Holroyd S., Jagels K., Karlyshev A.V., Moule S., Pallen M.J., Penn C.W., Quail M.A., Rajandream M.A., Rutherford K.M. , van Vliet A.H.M., Whitehead S., Barrell B.G. Nature 403:665-668(2000) [PubMed: 10688204] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: NCTC 11168 / Serotype O:2.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL111168 Genomic DNA. Translation: CAL34783.1.
PIR	E81412.
RefSeq	YP_002344067.1. NC_002163.1.
3D structure databases
ProteinModelPortal	Q9PHM9.
SMR	Q9PHM9. Positions 18-172.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	904968.
GenomeReviews	Gene locus Cj0638c in contig AL111168_GR.
KEGG	cje:Cj0638c.
PATRIC	20058221. VBICamJej33762_0630.
Phylogenomic databases
HOGENOM	HBG529150.
OMA	PNDFNVI.
ProtClustDB	CLSK872397.
Enzyme and pathway databases
BioCyc	CJEJ192222:CJ0638C-MONOMER.
Family and domain databases
HAMAP	MF_00209. Inorganic_PPase. [Tree]
InterPro	IPR008162. Pyrophosphatase. [Graphical view]
Gene3D	G3DSA:3.90.80.10. Pyrophosphatase. 1 hit.
KO	K01507.
PANTHER	PTHR10286. Pyrophosphatase. 1 hit.
Pfam	PF00719. Pyrophosphatase. 1 hit. [Graphical view]
SUPFAM	SSF50324. Pyrophosphatase. 1 hit.
PROSITE	PS00387. PPASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

IPYR_CAMJE

Accession

Primary (citable) accession number: Q9PHM9
Secondary accession number(s): Q0PAN0

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 20, 2002
Last sequence update:	October 1, 2000
Last modified:	January 25, 2012
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program