Q9PHM6 (PPNK_CAMJE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable inorganic polyphosphate/ATP-NAD kinase
Short name=Poly(P)/ATP NAD kinase
EC=2.7.1.23

Gene names

Name:	ppnK
Ordered Locus Names:	Cj0641

Organism

Campylobacter jejuni subsp. jejuni serotype O:2 (strain NCTC 11168) [Reference proteome] [HAMAP]

Taxonomic identifier

192222 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › delta/epsilon subdivisions › Epsilonproteobacteria › Campylobacterales › Campylobacteraceae › Campylobacter › Campylobacter jejuni › Campylobacter jejuni subsp. jejuni

Protein attributes

Sequence length	286 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus By similarity. HAMAP-Rule MF_00361
Catalytic activity	ATP + NAD+ = ADP + NADP+. HAMAP-Rule MF_00361
Cofactor	Divalent metal ions By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the NAD kinase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding NAD NADP Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	NAD metabolic process Inferred from electronic annotation. Source: InterPro NADP biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW NAD+ kinase activity Inferred from electronic annotation. Source: HAMAP metal ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 286	286	Probable inorganic polyphosphate/ATP-NAD kinase HAMAP-Rule MF_00361		PRO_0000120608

Sequences

	Sequence		Length	Mass (Da)
	Q9PHM6 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: E89F4DEAF039B32D	FASTA	286	32,382
	10 20 30 40 50 60 MQNKIDYKNI KKIGLVTRPN VSLDKEILKL QSILSIYKVE LVLLKESSEI LDLPKYGLDD 70 80 90 100 110 120 LFKISDFVIS LGGDGTLISL CRKACEYDKA VLGIHAGHLG FLTDFKVDEA ENFFQAFFQG 130 140 150 160 170 180 EFRIEKPYLL SIFLEDRQGK ILEKLAFNDV VISKNNQASM AHIEVFRKEK KFNEYFGDGL 190 200 210 220 230 240 IVATPAGSTA YNLSANGPIV YTLAQAFILT PVCSHSLTQR PIVLPKGFEI EIMAKDCMLC 250 260 270 280 IDGQENYKMN DFKSIKVGLS DKNVALIHPK NRDYFQILKE KLHWGN

References

[1]

"The genome sequence of the food-borne pathogen Campylobacter jejuni reveals hypervariable sequences." Parkhill J., Wren B.W., Mungall K.L., Ketley J.M., Churcher C.M., Basham D., Chillingworth T., Davies R.M., Feltwell T., Holroyd S., Jagels K., Karlyshev A.V., Moule S., Pallen M.J., Penn C.W., Quail M.A., Rajandream M.A., Rutherford K.M. , van Vliet A.H.M., Whitehead S., Barrell B.G. Nature 403:665-668(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: NCTC 11168.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL111168 Genomic DNA. Translation: CAL34786.1.
PIR	H81412.
RefSeq	YP_002344070.1. NC_002163.1.
3D structure databases
ProteinModelPortal	Q9PHM6.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9PHM6. 3 interactions.
STRING	192222.Cj0641.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAL34786; CAL34786; Cj0641.
GeneID	905135.
KEGG	cje:Cj0641.
PATRIC	20058227. VBICamJej33762_0633.
Phylogenomic databases
eggNOG	COG0061.
HOGENOM	HOG000227222.
KO	K00858.
OMA	IQMSEIA.
ProtClustDB	PRK14077.
Enzyme and pathway databases
BioCyc	CJEJ192222:GJTS-627-MONOMER.
Family and domain databases
Gene3D	2.60.200.30. 1 hit. 3.40.50.10330. 1 hit.
HAMAP	MF_00361. NAD_kinase.
InterPro	IPR017438. ATP-NAD_kinase_dom_1. IPR016064. ATP-NAD_kinase_PpnK-typ. IPR017437. ATP-NAD_kinase_PpnK-typ_all-b. IPR002504. PolyP/ATP_NADK_prd. [Graphical view]
PANTHER	PTHR20275. PTHR20275. 1 hit.
Pfam	PF01513. NAD_kinase. 1 hit. [Graphical view]
SUPFAM	SSF111331. ATP-NAD_kinase_PpnK-typ. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PPNK_CAMJE

Accession

Primary (citable) accession number: Q9PHM6
Secondary accession number(s): Q0PAM7

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 4, 2001
Last sequence update:	October 1, 2000
Last modified:	May 1, 2013
This is version 77 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program