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Q9PHM6

- NADK_CAMJE

UniProt

Q9PHM6 - NADK_CAMJE

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Protein

NAD kinase

Gene

nadK

Organism
Campylobacter jejuni subsp. jejuni serotype O:2 (strain NCTC 11168)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

Divalent metal ions.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei74 – 741Proton acceptorUniRule annotation
Binding sitei178 – 1781NADUniRule annotation
Binding sitei186 – 1861NAD; via carbonyl oxygenUniRule annotation
Binding sitei244 – 2441NADUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi74 – 752NADUniRule annotation
Nucleotide bindingi148 – 1492NADUniRule annotation
Nucleotide bindingi189 – 1946NADUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-HAMAP
  3. NAD+ kinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. NAD metabolic process Source: InterPro
  2. NADP biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, NAD, NADP, Nucleotide-binding

Enzyme and pathway databases

BioCyciCJEJ192222:GJTS-627-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
Alternative name(s):
ATP-dependent NAD kinaseUniRule annotation
Gene namesi
Name:nadKUniRule annotation
Ordered Locus Names:Cj0641
OrganismiCampylobacter jejuni subsp. jejuni serotype O:2 (strain NCTC 11168)
Taxonomic identifieri192222 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeCampylobacter
ProteomesiUP000000799: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 286286NAD kinasePRO_0000120608Add
BLAST

Interactioni

Protein-protein interaction databases

IntActiQ9PHM6. 3 interactions.
STRINGi192222.Cj0641.

Structurei

3D structure databases

ProteinModelPortaliQ9PHM6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0061.
HOGENOMiHOG000227222.
KOiK00858.
OMAiTHEMLYH.
OrthoDBiEOG6PZXDR.

Family and domain databases

Gene3Di2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPiMF_00361. NAD_kinase.
InterProiIPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view]
PANTHERiPTHR20275. PTHR20275. 1 hit.
PfamiPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9PHM6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQNKIDYKNI KKIGLVTRPN VSLDKEILKL QSILSIYKVE LVLLKESSEI
60 70 80 90 100
LDLPKYGLDD LFKISDFVIS LGGDGTLISL CRKACEYDKA VLGIHAGHLG
110 120 130 140 150
FLTDFKVDEA ENFFQAFFQG EFRIEKPYLL SIFLEDRQGK ILEKLAFNDV
160 170 180 190 200
VISKNNQASM AHIEVFRKEK KFNEYFGDGL IVATPAGSTA YNLSANGPIV
210 220 230 240 250
YTLAQAFILT PVCSHSLTQR PIVLPKGFEI EIMAKDCMLC IDGQENYKMN
260 270 280
DFKSIKVGLS DKNVALIHPK NRDYFQILKE KLHWGN
Length:286
Mass (Da):32,382
Last modified:October 1, 2000 - v1
Checksum:iE89F4DEAF039B32D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL111168 Genomic DNA. Translation: CAL34786.1.
PIRiH81412.
RefSeqiYP_002344070.1. NC_002163.1.

Genome annotation databases

EnsemblBacteriaiCAL34786; CAL34786; Cj0641.
GeneIDi905135.
KEGGicje:Cj0641.
PATRICi20058227. VBICamJej33762_0633.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL111168 Genomic DNA. Translation: CAL34786.1 .
PIRi H81412.
RefSeqi YP_002344070.1. NC_002163.1.

3D structure databases

ProteinModelPortali Q9PHM6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q9PHM6. 3 interactions.
STRINGi 192222.Cj0641.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAL34786 ; CAL34786 ; Cj0641 .
GeneIDi 905135.
KEGGi cje:Cj0641.
PATRICi 20058227. VBICamJej33762_0633.

Phylogenomic databases

eggNOGi COG0061.
HOGENOMi HOG000227222.
KOi K00858.
OMAi THEMLYH.
OrthoDBi EOG6PZXDR.

Enzyme and pathway databases

BioCyci CJEJ192222:GJTS-627-MONOMER.

Family and domain databases

Gene3Di 2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPi MF_00361. NAD_kinase.
InterProi IPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view ]
PANTHERi PTHR20275. PTHR20275. 1 hit.
Pfami PF01513. NAD_kinase. 1 hit.
[Graphical view ]
SUPFAMi SSF111331. SSF111331. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NCTC 11168.

Entry informationi

Entry nameiNADK_CAMJE
AccessioniPrimary (citable) accession number: Q9PHM6
Secondary accession number(s): Q0PAM7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 4, 2001
Last sequence update: October 1, 2000
Last modified: October 29, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3