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Q9PHK7

- ASSY_CAMJE

UniProt

Q9PHK7 - ASSY_CAMJE

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Protein

Argininosuccinate synthase

Gene

argG

Organism
Campylobacter jejuni subsp. jejuni serotype O:2 (strain NCTC 11168)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei38 – 381ATP; via amide nitrogen and carbonyl oxygenUniRule annotation
Binding sitei91 – 911CitrullineUniRule annotation
Binding sitei96 – 961CitrullineUniRule annotation
Binding sitei121 – 1211ATP; via amide nitrogenUniRule annotation
Binding sitei123 – 1231AspartateUniRule annotation
Binding sitei127 – 1271AspartateUniRule annotation
Binding sitei127 – 1271CitrullineUniRule annotation
Binding sitei128 – 1281AspartateUniRule annotation
Binding sitei131 – 1311CitrullineUniRule annotation
Binding sitei181 – 1811CitrullineUniRule annotation
Binding sitei190 – 1901CitrullineUniRule annotation
Binding sitei266 – 2661CitrullineUniRule annotation
Binding sitei278 – 2781CitrullineUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi11 – 199ATPUniRule annotation

GO - Molecular functioni

  1. argininosuccinate synthase activity Source: UniProtKB-HAMAP
  2. ATP binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. arginine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Amino-acid biosynthesis, Arginine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCJEJ192222:GJTS-647-MONOMER.
UniPathwayiUPA00068; UER00113.

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate synthaseUniRule annotation (EC:6.3.4.5UniRule annotation)
Alternative name(s):
Citrulline--aspartate ligaseUniRule annotation
Gene namesi
Name:argGUniRule annotation
Ordered Locus Names:Cj0665c
OrganismiCampylobacter jejuni subsp. jejuni serotype O:2 (strain NCTC 11168)
Taxonomic identifieri192222 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeCampylobacter
ProteomesiUP000000799: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 406406Argininosuccinate synthasePRO_0000148580Add
BLAST

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

IntActiQ9PHK7. 42 interactions.
STRINGi192222.Cj0665c.

Structurei

Secondary structure

1
406
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi7 – 115Combined sources
Helixi16 – 2813Combined sources
Beta strandi32 – 4110Combined sources
Helixi47 – 559Combined sources
Helixi60 – 623Combined sources
Beta strandi63 – 675Combined sources
Helixi69 – 757Combined sources
Helixi77 – 815Combined sources
Turni82 – 843Combined sources
Turni88 – 903Combined sources
Helixi94 – 11320Combined sources
Beta strandi116 – 1194Combined sources
Helixi128 – 13912Combined sources
Beta strandi144 – 1463Combined sources
Helixi148 – 1514Combined sources
Helixi158 – 1669Combined sources
Beta strandi179 – 1846Combined sources
Beta strandi189 – 1935Combined sources
Helixi194 – 1974Combined sources
Helixi205 – 2073Combined sources
Turni214 – 2163Combined sources
Beta strandi222 – 2298Combined sources
Beta strandi232 – 2365Combined sources
Helixi243 – 25614Combined sources
Beta strandi261 – 2677Combined sources
Beta strandi269 – 27911Combined sources
Helixi281 – 29717Combined sources
Helixi300 – 31920Combined sources
Beta strandi322 – 3243Combined sources
Helixi325 – 33612Combined sources
Turni337 – 3404Combined sources
Beta strandi343 – 3508Combined sources
Beta strandi353 – 3608Combined sources
Helixi382 – 40120Combined sources

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4NZPX-ray2.31A1-406[»]
ProteinModelPortaliQ9PHK7.
SMRiQ9PHK7. Positions 7-401.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the argininosuccinate synthase family. Type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0137.
HOGENOMiHOG000230093.
KOiK01940.
OMAiAPPEEAY.
OrthoDBiEOG6K9QCV.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPiMF_00005. Arg_succ_synth_type1.
InterProiIPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF00764. Arginosuc_synth. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00032. argG. 1 hit.
PROSITEiPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9PHK7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKNEVKKVVL AYSGGLDTSI ILKWLQDEYN CEVVTFTADI GQGEELEPAR
60 70 80 90 100
KKALSLGIKE ENIFIKDLRD EFVKDYVFPM FRANAIYEGE YLLGTSIARP
110 120 130 140 150
LIAKTQAQIA LQTGADAVSH GATGKGNDQV RFELGYLAFS PDLKIIAPWR
160 170 180 190 200
EWDLNSREKL LAYAQKHGID ISKKKGKSPY SMDANLLHIS YEGLVLEDPA
210 220 230 240 250
HAPEEDMWRW SKSPKDAPNE SEIIELDFQK GDLVAINGEK LSPAGLLTKL
260 270 280 290 300
NELGCKHGIG RLDIVENRYV GMKSRGCYET PGGTILLKAH RALESITLDR
310 320 330 340 350
EAAHLKDELM PKYASLIYNG YWFSPERMML QALIDESQIH ANGRVKLELY
360 370 380 390 400
KGNVMVIGRE SANDSLFNAA YCTFEEDEVY NQKDAAGFIK LNALRFIIAG

KNGRKF
Length:406
Mass (Da):45,578
Last modified:October 1, 2000 - v1
Checksum:i8A1E137AF30EC77F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL111168 Genomic DNA. Translation: CAL34806.1.
PIRiC81415.
RefSeqiYP_002344089.1. NC_002163.1.

Genome annotation databases

EnsemblBacteriaiCAL34806; CAL34806; Cj0665c.
GeneIDi904988.
KEGGicje:Cj0665c.
PATRICi20058275. VBICamJej33762_0657.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL111168 Genomic DNA. Translation: CAL34806.1 .
PIRi C81415.
RefSeqi YP_002344089.1. NC_002163.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4NZP X-ray 2.31 A 1-406 [» ]
ProteinModelPortali Q9PHK7.
SMRi Q9PHK7. Positions 7-401.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q9PHK7. 42 interactions.
STRINGi 192222.Cj0665c.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAL34806 ; CAL34806 ; Cj0665c .
GeneIDi 904988.
KEGGi cje:Cj0665c.
PATRICi 20058275. VBICamJej33762_0657.

Phylogenomic databases

eggNOGi COG0137.
HOGENOMi HOG000230093.
KOi K01940.
OMAi APPEEAY.
OrthoDBi EOG6K9QCV.

Enzyme and pathway databases

UniPathwayi UPA00068 ; UER00113 .
BioCyci CJEJ192222:GJTS-647-MONOMER.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPi MF_00005. Arg_succ_synth_type1.
InterProi IPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
Pfami PF00764. Arginosuc_synth. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00032. argG. 1 hit.
PROSITEi PS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NCTC 11168.

Entry informationi

Entry nameiASSY_CAMJE
AccessioniPrimary (citable) accession number: Q9PHK7
Secondary accession number(s): Q0PAK8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 23, 2003
Last sequence update: October 1, 2000
Last modified: October 29, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3