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Q9PH08

- AMPA_XYLFA

UniProt

Q9PH08 - AMPA_XYLFA

Protein

Probable cytosol aminopeptidase

Gene

pepA

Organism
Xylella fastidiosa (strain 9a5c)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    • Comment

    Functioni

    Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.UniRule annotation

    Catalytic activityi

    Release of an N-terminal amino acid, Xaa-|-Yaa-, in which Xaa is preferably Leu, but may be other amino acids including Pro although not Arg or Lys, and Yaa may be Pro. Amino acid amides and methyl esters are also readily hydrolyzed, but rates on arylamides are exceedingly low.UniRule annotation
    Release of an N-terminal amino acid, preferentially leucine, but not glutamic or aspartic acids.UniRule annotation

    Cofactori

    Binds 2 manganese ions per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi264 – 2641Manganese 2UniRule annotation
    Metal bindingi269 – 2691Manganese 1UniRule annotation
    Metal bindingi269 – 2691Manganese 2UniRule annotation
    Active sitei276 – 2761UniRule annotation
    Metal bindingi287 – 2871Manganese 2UniRule annotation
    Metal bindingi346 – 3461Manganese 1UniRule annotation
    Metal bindingi348 – 3481Manganese 1UniRule annotation
    Metal bindingi348 – 3481Manganese 2UniRule annotation
    Active sitei350 – 3501UniRule annotation

    GO - Molecular functioni

    1. aminopeptidase activity Source: UniProtKB-HAMAP
    2. manganese ion binding Source: UniProtKB-HAMAP
    3. metalloexopeptidase activity Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminopeptidase, Hydrolase, Protease

    Keywords - Ligandi

    Manganese, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable cytosol aminopeptidaseUniRule annotation (EC:3.4.11.1UniRule annotation)
    Alternative name(s):
    Leucine aminopeptidaseUniRule annotation (EC:3.4.11.10UniRule annotation)
    Short name:
    LAPUniRule annotation
    Leucyl aminopeptidaseUniRule annotation
    Gene namesi
    Name:pepAUniRule annotation
    Ordered Locus Names:XF_0138
    OrganismiXylella fastidiosa (strain 9a5c)
    Taxonomic identifieri160492 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXylella
    ProteomesiUP000000812: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 491491Probable cytosol aminopeptidasePRO_0000165818Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi160492.XF0138.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9PH08.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase M17 family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0260.
    KOiK01255.
    OMAiFAKAYNW.
    OrthoDBiEOG6FV8B3.

    Family and domain databases

    HAMAPiMF_00181. Cytosol_peptidase_M17.
    InterProiIPR011356. Leucine_aapep/pepB.
    IPR000819. Peptidase_M17_C.
    IPR023042. Peptidase_M17_leu_NH2_pept.
    IPR008283. Peptidase_M17_N.
    [Graphical view]
    PfamiPF00883. Peptidase_M17. 1 hit.
    PF02789. Peptidase_M17_N. 1 hit.
    [Graphical view]
    PRINTSiPR00481. LAMNOPPTDASE.
    PROSITEiPS00631. CYTOSOL_AP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9PH08-1 [UniParc]FASTAAdd to Basket

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    MALQFQLNQT TPQTVTTDCV IVGIYADKTL SPTAKTLDAA SGGRITALTA    50
    RGDLTGKSGT SALLHDLNGV TAPRVLVVGL GEADKFGPGQ YIKAVGDAVR 100
    ALKDAPVTHA LLTLSELPVK DRNAAWNIHQ AVIAADHAAY RYTATLGTSR 150
    KKAAESGLIT LAIHGQESSG LTLGQAIAEG VEYARALGNL PPNICTPVYL 200
    AETTAHFAAT HPGATCEILD ESKMEALGMG ALLAVARGSA NRPRLIVLKW 250
    NGGGDARPYV LVGKGITFDT GGVNLKTQGG IEEMKYDMCG GAAVIGTFVA 300
    AVKVRLPLNL IVIVPAVENA IDGNAYRPSD VITSMSGKTI EVGNTDAEGR 350
    LILCDALTYA ERFKPEALID VATLTGACMI ALGRAATGLM THHDDLANEL 400
    LTAGEHVHDR AWRLPLWDEY QNLLDSTFAD VYNIGGRWGG AITAGCFLSR 450
    FTEGQRWAHL DIAGSASNEG KRGMATGRPV GLLTQWLVDR C 491
    Length:491
    Mass (Da):51,723
    Last modified:October 1, 2000 - v1
    Checksum:i3D0576F8A7CAF3EE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE003849 Genomic DNA. Translation: AAF82951.1.
    PIRiF82843.
    RefSeqiNP_297431.1. NC_002488.3.
    WP_010892683.1. NC_002488.3.

    Genome annotation databases

    EnsemblBacteriaiAAF82951; AAF82951; XF_0138.
    GeneIDi1125656.
    KEGGixfa:XF0138.
    PATRICi24130178. VBIXylFas578_0145.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE003849 Genomic DNA. Translation: AAF82951.1 .
    PIRi F82843.
    RefSeqi NP_297431.1. NC_002488.3.
    WP_010892683.1. NC_002488.3.

    3D structure databases

    ProteinModelPortali Q9PH08.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 160492.XF0138.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAF82951 ; AAF82951 ; XF_0138 .
    GeneIDi 1125656.
    KEGGi xfa:XF0138.
    PATRICi 24130178. VBIXylFas578_0145.

    Phylogenomic databases

    eggNOGi COG0260.
    KOi K01255.
    OMAi FAKAYNW.
    OrthoDBi EOG6FV8B3.

    Family and domain databases

    HAMAPi MF_00181. Cytosol_peptidase_M17.
    InterProi IPR011356. Leucine_aapep/pepB.
    IPR000819. Peptidase_M17_C.
    IPR023042. Peptidase_M17_leu_NH2_pept.
    IPR008283. Peptidase_M17_N.
    [Graphical view ]
    Pfami PF00883. Peptidase_M17. 1 hit.
    PF02789. Peptidase_M17_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00481. LAMNOPPTDASE.
    PROSITEi PS00631. CYTOSOL_AP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of the plant pathogen Xylella fastidiosa."
      Simpson A.J.G., Reinach F.C., Arruda P., Abreu F.A., Acencio M., Alvarenga R., Alves L.M.C., Araya J.E., Baia G.S., Baptista C.S., Barros M.H., Bonaccorsi E.D., Bordin S., Bove J.M., Briones M.R.S., Bueno M.R.P., Camargo A.A., Camargo L.E.A.
      , Carraro D.M., Carrer H., Colauto N.B., Colombo C., Costa F.F., Costa M.C.R., Costa-Neto C.M., Coutinho L.L., Cristofani M., Dias-Neto E., Docena C., El-Dorry H., Facincani A.P., Ferreira A.J.S., Ferreira V.C.A., Ferro J.A., Fraga J.S., Franca S.C., Franco M.C., Frohme M., Furlan L.R., Garnier M., Goldman G.H., Goldman M.H.S., Gomes S.L., Gruber A., Ho P.L., Hoheisel J.D., Junqueira M.L., Kemper E.L., Kitajima J.P., Krieger J.E., Kuramae E.E., Laigret F., Lambais M.R., Leite L.C.C., Lemos E.G.M., Lemos M.V.F., Lopes S.A., Lopes C.R., Machado J.A., Machado M.A., Madeira A.M.B.N., Madeira H.M.F., Marino C.L., Marques M.V., Martins E.A.L., Martins E.M.F., Matsukuma A.Y., Menck C.F.M., Miracca E.C., Miyaki C.Y., Monteiro-Vitorello C.B., Moon D.H., Nagai M.A., Nascimento A.L.T.O., Netto L.E.S., Nhani A. Jr., Nobrega F.G., Nunes L.R., Oliveira M.A., de Oliveira M.C., de Oliveira R.C., Palmieri D.A., Paris A., Peixoto B.R., Pereira G.A.G., Pereira H.A. Jr., Pesquero J.B., Quaggio R.B., Roberto P.G., Rodrigues V., de Rosa A.J.M., de Rosa V.E. Jr., de Sa R.G., Santelli R.V., Sawasaki H.E., da Silva A.C.R., da Silva A.M., da Silva F.R., Silva W.A. Jr., da Silveira J.F., Silvestri M.L.Z., Siqueira W.J., de Souza A.A., de Souza A.P., Terenzi M.F., Truffi D., Tsai S.M., Tsuhako M.H., Vallada H., Van Sluys M.A., Verjovski-Almeida S., Vettore A.L., Zago M.A., Zatz M., Meidanis J., Setubal J.C.
      Nature 406:151-159(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 9a5c.

    Entry informationi

    Entry nameiAMPA_XYLFA
    AccessioniPrimary (citable) accession number: Q9PH08
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 8, 2002
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 84 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3