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Q9PH08

- AMPA_XYLFA

UniProt

Q9PH08 - AMPA_XYLFA

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Protein

Probable cytosol aminopeptidase

Gene

pepA

Organism
Xylella fastidiosa (strain 9a5c)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.UniRule annotation

Catalytic activityi

Release of an N-terminal amino acid, Xaa-|-Yaa-, in which Xaa is preferably Leu, but may be other amino acids including Pro although not Arg or Lys, and Yaa may be Pro. Amino acid amides and methyl esters are also readily hydrolyzed, but rates on arylamides are exceedingly low.UniRule annotation
Release of an N-terminal amino acid, preferentially leucine, but not glutamic or aspartic acids.UniRule annotation

Cofactori

Mn2+UniRule annotationNote: Binds 2 manganese ions per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi264 – 2641Manganese 2UniRule annotation
Metal bindingi269 – 2691Manganese 1UniRule annotation
Metal bindingi269 – 2691Manganese 2UniRule annotation
Active sitei276 – 2761UniRule annotation
Metal bindingi287 – 2871Manganese 2UniRule annotation
Metal bindingi346 – 3461Manganese 1UniRule annotation
Metal bindingi348 – 3481Manganese 1UniRule annotation
Metal bindingi348 – 3481Manganese 2UniRule annotation
Active sitei350 – 3501UniRule annotation

GO - Molecular functioni

  1. aminopeptidase activity Source: UniProtKB-HAMAP
  2. manganese ion binding Source: UniProtKB-HAMAP
  3. metalloexopeptidase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminopeptidase, Hydrolase, Protease

Keywords - Ligandi

Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable cytosol aminopeptidaseUniRule annotation (EC:3.4.11.1UniRule annotation)
Alternative name(s):
Leucine aminopeptidaseUniRule annotation (EC:3.4.11.10UniRule annotation)
Short name:
LAPUniRule annotation
Leucyl aminopeptidaseUniRule annotation
Gene namesi
Name:pepAUniRule annotation
Ordered Locus Names:XF_0138
OrganismiXylella fastidiosa (strain 9a5c)
Taxonomic identifieri160492 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXylella
ProteomesiUP000000812: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 491491Probable cytosol aminopeptidasePRO_0000165818Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi160492.XF0138.

Structurei

3D structure databases

ProteinModelPortaliQ9PH08.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M17 family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0260.
KOiK01255.
OMAiFAKAYNW.
OrthoDBiEOG6FV8B3.

Family and domain databases

HAMAPiMF_00181. Cytosol_peptidase_M17.
InterProiIPR011356. Leucine_aapep/pepB.
IPR000819. Peptidase_M17_C.
IPR023042. Peptidase_M17_leu_NH2_pept.
IPR008283. Peptidase_M17_N.
[Graphical view]
PfamiPF00883. Peptidase_M17. 1 hit.
PF02789. Peptidase_M17_N. 1 hit.
[Graphical view]
PRINTSiPR00481. LAMNOPPTDASE.
PROSITEiPS00631. CYTOSOL_AP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9PH08-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MALQFQLNQT TPQTVTTDCV IVGIYADKTL SPTAKTLDAA SGGRITALTA
60 70 80 90 100
RGDLTGKSGT SALLHDLNGV TAPRVLVVGL GEADKFGPGQ YIKAVGDAVR
110 120 130 140 150
ALKDAPVTHA LLTLSELPVK DRNAAWNIHQ AVIAADHAAY RYTATLGTSR
160 170 180 190 200
KKAAESGLIT LAIHGQESSG LTLGQAIAEG VEYARALGNL PPNICTPVYL
210 220 230 240 250
AETTAHFAAT HPGATCEILD ESKMEALGMG ALLAVARGSA NRPRLIVLKW
260 270 280 290 300
NGGGDARPYV LVGKGITFDT GGVNLKTQGG IEEMKYDMCG GAAVIGTFVA
310 320 330 340 350
AVKVRLPLNL IVIVPAVENA IDGNAYRPSD VITSMSGKTI EVGNTDAEGR
360 370 380 390 400
LILCDALTYA ERFKPEALID VATLTGACMI ALGRAATGLM THHDDLANEL
410 420 430 440 450
LTAGEHVHDR AWRLPLWDEY QNLLDSTFAD VYNIGGRWGG AITAGCFLSR
460 470 480 490
FTEGQRWAHL DIAGSASNEG KRGMATGRPV GLLTQWLVDR C
Length:491
Mass (Da):51,723
Last modified:October 1, 2000 - v1
Checksum:i3D0576F8A7CAF3EE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE003849 Genomic DNA. Translation: AAF82951.1.
PIRiF82843.
RefSeqiNP_297431.1. NC_002488.3.

Genome annotation databases

EnsemblBacteriaiAAF82951; AAF82951; XF_0138.
GeneIDi1125656.
KEGGixfa:XF0138.
PATRICi24130178. VBIXylFas578_0145.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE003849 Genomic DNA. Translation: AAF82951.1 .
PIRi F82843.
RefSeqi NP_297431.1. NC_002488.3.

3D structure databases

ProteinModelPortali Q9PH08.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 160492.XF0138.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAF82951 ; AAF82951 ; XF_0138 .
GeneIDi 1125656.
KEGGi xfa:XF0138.
PATRICi 24130178. VBIXylFas578_0145.

Phylogenomic databases

eggNOGi COG0260.
KOi K01255.
OMAi FAKAYNW.
OrthoDBi EOG6FV8B3.

Family and domain databases

HAMAPi MF_00181. Cytosol_peptidase_M17.
InterProi IPR011356. Leucine_aapep/pepB.
IPR000819. Peptidase_M17_C.
IPR023042. Peptidase_M17_leu_NH2_pept.
IPR008283. Peptidase_M17_N.
[Graphical view ]
Pfami PF00883. Peptidase_M17. 1 hit.
PF02789. Peptidase_M17_N. 1 hit.
[Graphical view ]
PRINTSi PR00481. LAMNOPPTDASE.
PROSITEi PS00631. CYTOSOL_AP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of the plant pathogen Xylella fastidiosa."
    Simpson A.J.G., Reinach F.C., Arruda P., Abreu F.A., Acencio M., Alvarenga R., Alves L.M.C., Araya J.E., Baia G.S., Baptista C.S., Barros M.H., Bonaccorsi E.D., Bordin S., Bove J.M., Briones M.R.S., Bueno M.R.P., Camargo A.A., Camargo L.E.A.
    , Carraro D.M., Carrer H., Colauto N.B., Colombo C., Costa F.F., Costa M.C.R., Costa-Neto C.M., Coutinho L.L., Cristofani M., Dias-Neto E., Docena C., El-Dorry H., Facincani A.P., Ferreira A.J.S., Ferreira V.C.A., Ferro J.A., Fraga J.S., Franca S.C., Franco M.C., Frohme M., Furlan L.R., Garnier M., Goldman G.H., Goldman M.H.S., Gomes S.L., Gruber A., Ho P.L., Hoheisel J.D., Junqueira M.L., Kemper E.L., Kitajima J.P., Krieger J.E., Kuramae E.E., Laigret F., Lambais M.R., Leite L.C.C., Lemos E.G.M., Lemos M.V.F., Lopes S.A., Lopes C.R., Machado J.A., Machado M.A., Madeira A.M.B.N., Madeira H.M.F., Marino C.L., Marques M.V., Martins E.A.L., Martins E.M.F., Matsukuma A.Y., Menck C.F.M., Miracca E.C., Miyaki C.Y., Monteiro-Vitorello C.B., Moon D.H., Nagai M.A., Nascimento A.L.T.O., Netto L.E.S., Nhani A. Jr., Nobrega F.G., Nunes L.R., Oliveira M.A., de Oliveira M.C., de Oliveira R.C., Palmieri D.A., Paris A., Peixoto B.R., Pereira G.A.G., Pereira H.A. Jr., Pesquero J.B., Quaggio R.B., Roberto P.G., Rodrigues V., de Rosa A.J.M., de Rosa V.E. Jr., de Sa R.G., Santelli R.V., Sawasaki H.E., da Silva A.C.R., da Silva A.M., da Silva F.R., Silva W.A. Jr., da Silveira J.F., Silvestri M.L.Z., Siqueira W.J., de Souza A.A., de Souza A.P., Terenzi M.F., Truffi D., Tsai S.M., Tsuhako M.H., Vallada H., Van Sluys M.A., Verjovski-Almeida S., Vettore A.L., Zago M.A., Zatz M., Meidanis J., Setubal J.C.
    Nature 406:151-159(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 9a5c.

Entry informationi

Entry nameiAMPA_XYLFA
AccessioniPrimary (citable) accession number: Q9PH08
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: October 1, 2000
Last modified: November 26, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3