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Q9PH08

- AMPA_XYLFA

UniProt

Q9PH08 - AMPA_XYLFA

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Protein
Probable cytosol aminopeptidase
Gene
pepA, XF_0138
Organism
Xylella fastidiosa (strain 9a5c)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides By similarity.UniRule annotation

Catalytic activityi

Release of an N-terminal amino acid, Xaa-|-Yaa-, in which Xaa is preferably Leu, but may be other amino acids including Pro although not Arg or Lys, and Yaa may be Pro. Amino acid amides and methyl esters are also readily hydrolyzed, but rates on arylamides are exceedingly low.UniRule annotation
Release of an N-terminal amino acid, preferentially leucine, but not glutamic or aspartic acids.

Cofactori

Binds 2 manganese ions per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi264 – 2641Manganese 2 By similarity
Metal bindingi269 – 2691Manganese 1 By similarity
Metal bindingi269 – 2691Manganese 2 By similarity
Active sitei276 – 2761 Reviewed prediction
Metal bindingi287 – 2871Manganese 2 By similarity
Metal bindingi346 – 3461Manganese 1 By similarity
Metal bindingi348 – 3481Manganese 1 By similarity
Metal bindingi348 – 3481Manganese 2 By similarity
Active sitei350 – 3501 Reviewed prediction

GO - Molecular functioni

  1. aminopeptidase activity Source: UniProtKB-HAMAP
  2. manganese ion binding Source: UniProtKB-HAMAP
  3. metalloexopeptidase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminopeptidase, Hydrolase, Protease

Keywords - Ligandi

Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable cytosol aminopeptidase (EC:3.4.11.1)
Alternative name(s):
Leucine aminopeptidase (EC:3.4.11.10)
Short name:
LAP
Leucyl aminopeptidase
Gene namesi
Name:pepA
Ordered Locus Names:XF_0138
OrganismiXylella fastidiosa (strain 9a5c)
Taxonomic identifieri160492 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXylella
ProteomesiUP000000812: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 491491Probable cytosol aminopeptidaseUniRule annotation
PRO_0000165818Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi160492.XF0138.

Structurei

3D structure databases

ProteinModelPortaliQ9PH08.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M17 family.

Phylogenomic databases

eggNOGiCOG0260.
KOiK01255.
OMAiFAKAYNW.
OrthoDBiEOG6FV8B3.

Family and domain databases

HAMAPiMF_00181. Cytosol_peptidase_M17.
InterProiIPR011356. Leucine_aapep/pepB.
IPR000819. Peptidase_M17_C.
IPR023042. Peptidase_M17_leu_NH2_pept.
IPR008283. Peptidase_M17_N.
[Graphical view]
PfamiPF00883. Peptidase_M17. 1 hit.
PF02789. Peptidase_M17_N. 1 hit.
[Graphical view]
PRINTSiPR00481. LAMNOPPTDASE.
PROSITEiPS00631. CYTOSOL_AP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9PH08-1 [UniParc]FASTAAdd to Basket

« Hide

MALQFQLNQT TPQTVTTDCV IVGIYADKTL SPTAKTLDAA SGGRITALTA    50
RGDLTGKSGT SALLHDLNGV TAPRVLVVGL GEADKFGPGQ YIKAVGDAVR 100
ALKDAPVTHA LLTLSELPVK DRNAAWNIHQ AVIAADHAAY RYTATLGTSR 150
KKAAESGLIT LAIHGQESSG LTLGQAIAEG VEYARALGNL PPNICTPVYL 200
AETTAHFAAT HPGATCEILD ESKMEALGMG ALLAVARGSA NRPRLIVLKW 250
NGGGDARPYV LVGKGITFDT GGVNLKTQGG IEEMKYDMCG GAAVIGTFVA 300
AVKVRLPLNL IVIVPAVENA IDGNAYRPSD VITSMSGKTI EVGNTDAEGR 350
LILCDALTYA ERFKPEALID VATLTGACMI ALGRAATGLM THHDDLANEL 400
LTAGEHVHDR AWRLPLWDEY QNLLDSTFAD VYNIGGRWGG AITAGCFLSR 450
FTEGQRWAHL DIAGSASNEG KRGMATGRPV GLLTQWLVDR C 491
Length:491
Mass (Da):51,723
Last modified:October 1, 2000 - v1
Checksum:i3D0576F8A7CAF3EE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE003849 Genomic DNA. Translation: AAF82951.1.
PIRiF82843.
RefSeqiNP_297431.1. NC_002488.3.
WP_010892683.1. NC_002488.3.

Genome annotation databases

EnsemblBacteriaiAAF82951; AAF82951; XF_0138.
GeneIDi1125656.
KEGGixfa:XF0138.
PATRICi24130178. VBIXylFas578_0145.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE003849 Genomic DNA. Translation: AAF82951.1 .
PIRi F82843.
RefSeqi NP_297431.1. NC_002488.3.
WP_010892683.1. NC_002488.3.

3D structure databases

ProteinModelPortali Q9PH08.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 160492.XF0138.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAF82951 ; AAF82951 ; XF_0138 .
GeneIDi 1125656.
KEGGi xfa:XF0138.
PATRICi 24130178. VBIXylFas578_0145.

Phylogenomic databases

eggNOGi COG0260.
KOi K01255.
OMAi FAKAYNW.
OrthoDBi EOG6FV8B3.

Family and domain databases

HAMAPi MF_00181. Cytosol_peptidase_M17.
InterProi IPR011356. Leucine_aapep/pepB.
IPR000819. Peptidase_M17_C.
IPR023042. Peptidase_M17_leu_NH2_pept.
IPR008283. Peptidase_M17_N.
[Graphical view ]
Pfami PF00883. Peptidase_M17. 1 hit.
PF02789. Peptidase_M17_N. 1 hit.
[Graphical view ]
PRINTSi PR00481. LAMNOPPTDASE.
PROSITEi PS00631. CYTOSOL_AP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of the plant pathogen Xylella fastidiosa."
    Simpson A.J.G., Reinach F.C., Arruda P., Abreu F.A., Acencio M., Alvarenga R., Alves L.M.C., Araya J.E., Baia G.S., Baptista C.S., Barros M.H., Bonaccorsi E.D., Bordin S., Bove J.M., Briones M.R.S., Bueno M.R.P., Camargo A.A., Camargo L.E.A.
    , Carraro D.M., Carrer H., Colauto N.B., Colombo C., Costa F.F., Costa M.C.R., Costa-Neto C.M., Coutinho L.L., Cristofani M., Dias-Neto E., Docena C., El-Dorry H., Facincani A.P., Ferreira A.J.S., Ferreira V.C.A., Ferro J.A., Fraga J.S., Franca S.C., Franco M.C., Frohme M., Furlan L.R., Garnier M., Goldman G.H., Goldman M.H.S., Gomes S.L., Gruber A., Ho P.L., Hoheisel J.D., Junqueira M.L., Kemper E.L., Kitajima J.P., Krieger J.E., Kuramae E.E., Laigret F., Lambais M.R., Leite L.C.C., Lemos E.G.M., Lemos M.V.F., Lopes S.A., Lopes C.R., Machado J.A., Machado M.A., Madeira A.M.B.N., Madeira H.M.F., Marino C.L., Marques M.V., Martins E.A.L., Martins E.M.F., Matsukuma A.Y., Menck C.F.M., Miracca E.C., Miyaki C.Y., Monteiro-Vitorello C.B., Moon D.H., Nagai M.A., Nascimento A.L.T.O., Netto L.E.S., Nhani A. Jr., Nobrega F.G., Nunes L.R., Oliveira M.A., de Oliveira M.C., de Oliveira R.C., Palmieri D.A., Paris A., Peixoto B.R., Pereira G.A.G., Pereira H.A. Jr., Pesquero J.B., Quaggio R.B., Roberto P.G., Rodrigues V., de Rosa A.J.M., de Rosa V.E. Jr., de Sa R.G., Santelli R.V., Sawasaki H.E., da Silva A.C.R., da Silva A.M., da Silva F.R., Silva W.A. Jr., da Silveira J.F., Silvestri M.L.Z., Siqueira W.J., de Souza A.A., de Souza A.P., Terenzi M.F., Truffi D., Tsai S.M., Tsuhako M.H., Vallada H., Van Sluys M.A., Verjovski-Almeida S., Vettore A.L., Zago M.A., Zatz M., Meidanis J., Setubal J.C.
    Nature 406:151-159(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 9a5c.

Entry informationi

Entry nameiAMPA_XYLFA
AccessioniPrimary (citable) accession number: Q9PH08
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: October 1, 2000
Last modified: September 3, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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