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Protein

Phosphoribosylformylglycinamidine cyclo-ligase

Gene

purM

Organism
Xylella fastidiosa (strain 9a5c)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotation

Pathwayi: IMP biosynthesis via de novo pathway

This protein is involved in step 2 of the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Phosphoribosylformylglycinamidine synthase (purL)
  2. Phosphoribosylformylglycinamidine cyclo-ligase (purM)
This subpathway is part of the pathway IMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide, the pathway IMP biosynthesis via de novo pathway and in Purine metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processPurine biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciXFAS160492:G1FZ5-529-MONOMER.
UniPathwayiUPA00074; UER00129.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosylformylglycinamidine cyclo-ligaseUniRule annotation (EC:6.3.3.1UniRule annotation)
Alternative name(s):
AIR synthaseUniRule annotation
AIRSUniRule annotation
Phosphoribosyl-aminoimidazole synthetaseUniRule annotation
Gene namesi
Name:purMUniRule annotation
Ordered Locus Names:XF_0587
OrganismiXylella fastidiosa (strain 9a5c)
Taxonomic identifieri160492 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXylella
Proteomesi
  • UP000000812 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001482761 – 351Phosphoribosylformylglycinamidine cyclo-ligaseAdd BLAST351

Interactioni

Protein-protein interaction databases

STRINGi160492.XF0587.

Structurei

3D structure databases

ProteinModelPortaliQ9PFS0.
SMRiQ9PFS0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AIR synthase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CXB. Bacteria.
COG0150. LUCA.
KOiK01933.
OMAiNHCVNDI.
OrthoDBiPOG091H0128.

Family and domain databases

CDDicd02196. PurM. 1 hit.
Gene3Di3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPiMF_00741. AIRS. 1 hit.
InterProiView protein in InterPro
IPR010918. PurM-like_C_dom.
IPR036676. PurM-like_C_sf.
IPR016188. PurM-like_N.
IPR036921. PurM-like_N_sf.
IPR004733. PurM_cligase.
PANTHERiPTHR10520. PTHR10520. 1 hit.
PfamiView protein in Pfam
PF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
SUPFAMiSSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsiTIGR00878. purM. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9PFS0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTLTSPSTT PLTYRDAGVD IDAGNTLVER IKPLVKRSFR PEVMSGLGGF
60 70 80 90 100
GALFNLAGKY KEPVLVSGTD GVGTKLKLAQ QLNRHNTIGI DLVAMCVNDV
110 120 130 140 150
LVQGAEPLFF LDYFATGKLD IDTATAVISG IALGCEQSGC ALIGGETAEM
160 170 180 190 200
PDMYPPGEYD LAGFCVAAVE KSQLLDGSQV REGDVLIGIA SSGPHSNGYS
210 220 230 240 250
LIRRIYERAG SPADLDIHGT RLIDTLMAPT TLYVKPILKL LHTHSDAIHA
260 270 280 290 300
MAHITGGGLT ENIIRVIPPN LGLRIDANAW TQPPVFQWLQ SEGALADTEM
310 320 330 340 350
WRTFNCGIGF VLVATPNQVA PLGQALDNQG LAHWQIGRVF TPVGNERVHI

G
Length:351
Mass (Da):37,499
Last modified:October 1, 2000 - v1
Checksum:iC6E945CF2F545652
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE003849 Genomic DNA. Translation: AAF83397.1.
PIRiE82789.
RefSeqiWP_010893113.1. NC_002488.3.

Genome annotation databases

EnsemblBacteriaiAAF83397; AAF83397; XF_0587.
GeneIDi1126118.
KEGGixfa:XF_0587.
PATRICifig|160492.11.peg.627.

Similar proteinsi

Entry informationi

Entry nameiPUR5_XYLFA
AccessioniPrimary (citable) accession number: Q9PFS0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: October 1, 2000
Last modified: February 28, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome