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Protein

dCTP deaminase

Gene

dcd

Organism
Xylella fastidiosa (strain 9a5c)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the deamination of dCTP to dUTP.UniRule annotation

Catalytic activityi

dCTP + H2O = dUTP + NH3.UniRule annotation

Pathwayi: dUMP biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes dUMP from dCTP (dUTP route).UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. dCTP deaminase (dcd)
  2. Deoxyuridine 5'-triphosphate nucleotidohydrolase (dut)
This subpathway is part of the pathway dUMP biosynthesis, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes dUMP from dCTP (dUTP route), the pathway dUMP biosynthesis and in Pyrimidine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei138Proton donor/acceptorUniRule annotation1
Binding sitei157dCTPUniRule annotation1
Binding sitei173dCTPUniRule annotation1
Binding sitei183dCTPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi112 – 117dCTP bindingUniRule annotation6
Nucleotide bindingi136 – 138dCTP bindingUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processNucleotide metabolism
LigandNucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00610; UER00665

Names & Taxonomyi

Protein namesi
Recommended name:
dCTP deaminaseUniRule annotation (EC:3.5.4.13UniRule annotation)
Alternative name(s):
Deoxycytidine triphosphate deaminaseUniRule annotation
Gene namesi
Name:dcdUniRule annotation
Ordered Locus Names:XF_0762
OrganismiXylella fastidiosa (strain 9a5c)
Taxonomic identifieri160492 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXylella
Proteomesi
  • UP000000812 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001560221 – 191dCTP deaminaseAdd BLAST191

Proteomic databases

PRIDEiQ9PFB6

Interactioni

Subunit structurei

Homotrimer.UniRule annotation

Protein-protein interaction databases

STRINGi160492.XF0762

Structurei

3D structure databases

ProteinModelPortaliQ9PFB6
SMRiQ9PFB6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the dCTP deaminase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DHP Bacteria
COG0717 LUCA
KOiK01494
OMAiGQLCLFR
OrthoDBiPOG091H02A6

Family and domain databases

CDDicd07557 trimeric_dUTPase, 1 hit
Gene3Di2.70.40.10, 1 hit
HAMAPiMF_00146 dCTP_deaminase, 1 hit
InterProiView protein in InterPro
IPR011962 dCTP_deaminase
IPR029054 dUTPase-like
IPR036157 dUTPase-like_sf
IPR033704 dUTPase_trimeric
PfamiView protein in Pfam
PF00692 dUTPase, 1 hit
SUPFAMiSSF51283 SSF51283, 1 hit
TIGRFAMsiTIGR02274 dCTP_deam, 1 hit

Sequencei

Sequence statusi: Complete.

Q9PFB6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSIKSDRWIR HMAQQHGMIA PFEPGQIKQN ATGQRIVSYG TSSYGYDVRC
60 70 80 90 100
SREFKIFTNI NSTIVDPKQF DNGSFIDVES DVCIIPPNSF ALARTIEYFR
110 120 130 140 150
IPRNVLVICL GKSTYARCGI IVNVTPLEPE WEGHVTLEFS NTTPLPARIY
160 170 180 190
ANEGVAQMLF LQADPDDVCQ TSYRDRNGKY QGQTGVTLPR T
Length:191
Mass (Da):21,531
Last modified:October 1, 2000 - v1
Checksum:iD7B23653F94B3649
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE003849 Genomic DNA Translation: AAF83572.1
PIRiG82765
RefSeqiWP_010893285.1, NC_002488.3

Genome annotation databases

EnsemblBacteriaiAAF83572; AAF83572; XF_0762
GeneIDi33198007
KEGGixfa:XF_0762

Similar proteinsi

Entry informationi

Entry nameiDCD_XYLFA
AccessioniPrimary (citable) accession number: Q9PFB6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: October 1, 2000
Last modified: May 23, 2018
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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