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Protein

Adenosylhomocysteinase

Gene

ahcY

Organism
Xylella fastidiosa (strain 9a5c)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.UniRule annotation

Catalytic activityi

S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine.UniRule annotation

Cofactori

NAD+UniRule annotationNote: Binds 1 NAD+ per subunit.UniRule annotation

Pathwayi: L-homocysteine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-homocysteine from S-adenosyl-L-homocysteine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Adenosylhomocysteinase (ahcY)
This subpathway is part of the pathway L-homocysteine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-homocysteine from S-adenosyl-L-homocysteine, the pathway L-homocysteine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei63SubstrateUniRule annotation1
Binding sitei142SubstrateUniRule annotation1
Binding sitei203SubstrateUniRule annotation1
Binding sitei233SubstrateUniRule annotation1
Binding sitei237SubstrateUniRule annotation1
Binding sitei238NADUniRule annotation1
Binding sitei290NADUniRule annotation1
Binding sitei325NADUniRule annotation1
Binding sitei394NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi204 – 206NADUniRule annotation3
Nucleotide bindingi267 – 272NADUniRule annotation6
Nucleotide bindingi346 – 348NADUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processOne-carbon metabolism
LigandNAD

Enzyme and pathway databases

UniPathwayiUPA00314; UER00076.

Names & Taxonomyi

Protein namesi
Recommended name:
AdenosylhomocysteinaseUniRule annotation (EC:3.3.1.1UniRule annotation)
Alternative name(s):
S-adenosyl-L-homocysteine hydrolaseUniRule annotation
Short name:
AdoHcyaseUniRule annotation
Gene namesi
Name:ahcYUniRule annotation
Ordered Locus Names:XF_1037
OrganismiXylella fastidiosa (strain 9a5c)
Taxonomic identifieri160492 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXylella
Proteomesi
  • UP000000812 Componenti: Chromosome

Subcellular locationi

Q9PEJ1:
  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001169981 – 480AdenosylhomocysteinaseAdd BLAST480

Proteomic databases

PRIDEiQ9PEJ1.

Interactioni

Protein-protein interaction databases

STRINGi160492.XF1037.

Structurei

3D structure databases

ProteinModelPortaliQ9PEJ1.
SMRiQ9PEJ1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the adenosylhomocysteinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C3E. Bacteria.
COG0499. LUCA.
KOiK01251.
OMAiTGNRDII.
OrthoDBiPOG091H00W2.

Family and domain databases

CDDicd00401. SAHH. 1 hit.
HAMAPiMF_00563. AdoHcyase. 1 hit.
InterProiView protein in InterPro
IPR034373. Adenosylhomocysteinase.
IPR000043. Adenosylhomocysteinase-like.
IPR015878. Ado_hCys_hydrolase_NAD-bd.
IPR036291. NAD(P)-bd_dom_sf.
IPR020082. S-Ado-L-homoCys_hydrolase_CS.
PANTHERiPTHR23420. PTHR23420. 1 hit.
PfamiView protein in Pfam
PF05221. AdoHcyase. 1 hit.
PF00670. AdoHcyase_NAD. 1 hit.
PIRSFiPIRSF001109. Ad_hcy_hydrolase. 1 hit.
SMARTiView protein in SMART
SM00996. AdoHcyase. 1 hit.
SM00997. AdoHcyase_NAD. 1 hit.
SUPFAMiSSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR00936. ahcY. 1 hit.
PROSITEiView protein in PROSITE
PS00738. ADOHCYASE_1. 1 hit.
PS00739. ADOHCYASE_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9PEJ1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNTHPQTSPN THYKIADISL TDWGRKEIDI AEHEMPGLMS IRRKYASKQP
60 70 80 90 100
LKGVRVTGSL HMTIQTAVLI ETLKDIGADV RWASCNIFST QDHAAAAIAT
110 120 130 140 150
SGTPVFAWKG ETLEEYWDCT LQALTFTLSD GTLTGPELIV DDGGDATLLI
160 170 180 190 200
HKGYELENGS TWVDEPSDSL EEQVIKRLLK RIAIERPGYW TRVVNDWKGV
210 220 230 240 250
SEETTTGVHR LYQIAATGRL LVPAINVNDS VTKSKFDNLY GCRESLADGL
260 270 280 290 300
KRAMDVMLAG KLAVVCGYGD VGKGSAHSLR AYGARVIVTE IDPICALQAA
310 320 330 340 350
MEGFEVTTVE DTLGQADIYV TTTGNKDVIR IEHMTAMKDQ VIVCNIGHFD
360 370 380 390 400
NEIQVDALNA LAGVQKINIK PQVDKFILPN GNTLFLLAEG RLVNLGCATG
410 420 430 440 450
HPSFVMSNSF ANQTLAQIDL WQNKDVYEKN VYRLPKKLDE EVARLHLEKI
460 470 480
GVKLTTLTAN QAAYLGISVE GPFKPEHYRY
Length:480
Mass (Da):52,936
Last modified:June 6, 2002 - v2
Checksum:i272CDFBFBB997CA7
GO

Sequence cautioni

Q9PEJ1: The sequence AAF83847 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE003849 Genomic DNA. Translation: AAF83847.1. Different initiation.
PIRiD82730.
RefSeqiWP_010893556.1. NC_002488.3.

Genome annotation databases

EnsemblBacteriaiAAF83847; AAF83847; XF_1037.
GeneIDi1126574.
KEGGixfa:XF_1037.

Similar proteinsi

Entry informationi

Entry nameiSAHH_XYLFA
AccessioniPrimary (citable) accession number: Q9PEJ1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 6, 2002
Last sequence update: June 6, 2002
Last modified: October 25, 2017
This is version 104 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families