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Protein

Lipid A export ATP-binding/permease protein MsbA

Gene

msbA

Organism
Xylella fastidiosa (strain 9a5c)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi380 – 387ATPUniRule annotation8

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase
Biological processLipid transport, Transport
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid A export ATP-binding/permease protein MsbAUniRule annotation (EC:3.6.3.-UniRule annotation)
Gene namesi
Name:msbAUniRule annotation
Ordered Locus Names:XF_1081
OrganismiXylella fastidiosa (strain 9a5c)
Taxonomic identifieri160492 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXylella
Proteomesi
  • UP000000812 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei29 – 49HelicalUniRule annotationAdd BLAST21
Transmembranei68 – 88HelicalUniRule annotationAdd BLAST21
Transmembranei157 – 177HelicalUniRule annotationAdd BLAST21
Transmembranei254 – 274HelicalUniRule annotationAdd BLAST21
Transmembranei283 – 303HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000926081 – 589Lipid A export ATP-binding/permease protein MsbAAdd BLAST589

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi160492.XF1081.

Structurei

3D structure databases

ProteinModelPortaliQ9PEE7.
SMRiQ9PEE7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 314ABC transmembrane type-1UniRule annotationAdd BLAST284
Domaini346 – 582ABC transporterUniRule annotationAdd BLAST237

Domaini

In MsbA the ATP-binding domain (NBD) and the transmembrane domain (TMD) are fused.

Sequence similaritiesi

Belongs to the ABC transporter superfamily. Lipid exporter (TC 3.A.1.106) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105BZ1. Bacteria.
COG1132. LUCA.
KOiK11085.
OMAiHERVQGM.
OrthoDBiPOG091H00DB.

Family and domain databases

Gene3Di1.20.1560.10. 1 hit.
InterProiView protein in InterPro
IPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR036640. ABC1_TM_sf.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR011917. ABC_transpr_lipidA.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF00664. ABC_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
SMARTiView protein in SMART
SM00382. AAA. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF90123. SSF90123. 1 hit.
TIGRFAMsiTIGR02203. MsbA_lipidA. 1 hit.
PROSITEiView protein in PROSITE
PS50929. ABC_TM1F. 1 hit.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
PS51239. MSBA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9PEE7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNVLSGAMRY ATPWRTYRRL LSYAREYRWL LVVAACGALL EAVAGSTFLA
60 70 80 90 100
LMKPITNETF IERNREVALW LPLGIVGLFL LRGIAGYITD MAMGRAARSI
110 120 130 140 150
ARDFRVCVLT KYFRLPGSRF DGEPVASMLV RLGSDSEQVA HAVIDAMKVM
160 170 180 190 200
VQQTLQVIGA LVVMLWYSWT VTLAILLVAP LLAWVMQRVA KRYRRISHHI
210 220 230 240 250
QESNAQLMQA ADQALSNYQD VKVYAAQESE LERYARLANI NLGLAIKVES
260 270 280 290 300
TRSLSSAAVQ LLGAVGLAML LLIAGHEALA GRLSPGDFVS LMTSMIAVIP
310 320 330 340 350
ALKQLTNVQN MLQSGIASAQ RLFSVLDSPD ELDTGRRPLG RARGFIEFRG
360 370 380 390 400
ITARYPGRSA PVLDSVSFVA APGTVTAIVG RSGSGKSSLI KLIPRFYEPE
410 420 430 440 450
SGQILLDGHP LQDYLLADLR RQIALVGQQV MLFDGSIAEN IAYGEMRQVV
460 470 480 490 500
SEEIERVVVD ANAQDFVNQL PEGLQFQVGV KGGRLSGGQR QRLAIARAML
510 520 530 540 550
KDAPILILDE ATAALDNESE RLVQDALQRL MPERTTLVIA HRLSTIKHAD
560 570 580
QVLVMDQGRI IESGTHVDLL ARDGLYAYLY SMQFRERPT
Length:589
Mass (Da):64,919
Last modified:October 1, 2000 - v1
Checksum:i78FB21CD324C864E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE003849 Genomic DNA. Translation: AAF83891.1.
PIRiF82726.

Genome annotation databases

EnsemblBacteriaiAAF83891; AAF83891; XF_1081.
KEGGixfa:XF_1081.

Similar proteinsi

Entry informationi

Entry nameiMSBA_XYLFA
AccessioniPrimary (citable) accession number: Q9PEE7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: October 1, 2000
Last modified: October 25, 2017
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families