Reviewed, UniProtKB/Swiss-Prot Q9PD69 (PIP_XYLFA)

Names and origin

Protein names

Recommended name:
    Proline iminopeptidase
      Short name=PIP
    EC=3.4.11.5
Alternative name(s):
    Prolyl aminopeptidase
      Short name=PAP

Gene names

Name:	pip
Ordered Locus Names:	XF_1510

Organism

Xylella fastidiosa [Complete proteome] [HAMAP]

Taxonomic identifier

2371 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Xanthomonadales › Xanthomonadaceae › Xylella

Protein attributes

Sequence length	313 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Specifically catalyzes the removal of N-terminal proline residues from peptides By similarity.
Catalytic activity	Release of N-terminal proline from a peptide.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the peptidase S33 family.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Aminopeptidase Hydrolase Protease
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	proteolysis Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	aminopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 313	313	Proline iminopeptidase		PRO_0000080848
Sites
	Active site	110	1	Nucleophile By similarity
	Active site	266	1	By similarity
	Active site	294	1	Proton donor By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9PD69-1 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: 7A351C54DEF11636	FASTA	313	35,592
	10 20 30 40 50 60 MRTLYPEVTP FEHGILCVDD NHRLYYEQCG NPHGKPVVIL HGGPGSGCND KMRRFHDPDK 70 80 90 100 110 120 YRIVLFDQRG AGRSTPHANL TNNTTWDLVA DIEKLRVALG ITRWQVFGGS WGSTLALAYA 130 140 150 160 170 180 QTHPEQTTEL VLRGIFMLRR WELEWFYQEG ASHLFPDAWD RYIAVIPPVE RHDLISAFHR 190 200 210 220 230 240 RLTSEDEATR LAAAQAWSLW EGATSCLYMD QDFIASHENP HFALAFARIE NHYFVNGGFF 250 260 270 280 290 300 EVENQLLRDA QRIANIPGVI VHGRYDVVCP LQNAWDLHKV WPKASLKITP GAGHSAFEPQ 310 NIDALVCATD SFV

References

[1]

"The genome sequence of the plant pathogen Xylella fastidiosa." Simpson A.J.G., Reinach F.C., Arruda P., Abreu F.A., Acencio M., Alvarenga R., Alves L.M.C., Araya J.E., Baia G.S., Baptista C.S., Barros M.H., Bonaccorsi E.D., Bordin S., Bove J.M., Briones M.R.S., Bueno M.R.P., Camargo A.A., Camargo L.E.A. , Carraro D.M., Carrer H., Colauto N.B., Colombo C., Costa F.F., Costa M.C.R., Costa-Neto C.M., Coutinho L.L., Cristofani M., Dias-Neto E., Docena C., El-Dorry H., Facincani A.P., Ferreira A.J.S., Ferreira V.C.A., Ferro J.A., Fraga J.S., Franca S.C., Franco M.C., Frohme M., Furlan L.R., Garnier M., Goldman G.H., Goldman M.H.S., Gomes S.L., Gruber A., Ho P.L., Hoheisel J.D., Junqueira M.L., Kemper E.L., Kitajima J.P., Krieger J.E., Kuramae E.E., Laigret F., Lambais M.R., Leite L.C.C., Lemos E.G.M., Lemos M.V.F., Lopes S.A., Lopes C.R., Machado J.A., Machado M.A., Madeira A.M.B.N., Madeira H.M.F., Marino C.L., Marques M.V., Martins E.A.L., Martins E.M.F., Matsukuma A.Y., Menck C.F.M., Miracca E.C., Miyaki C.Y., Monteiro-Vitorello C.B., Moon D.H., Nagai M.A., Nascimento A.L.T.O., Netto L.E.S., Nhani A. Jr., Nobrega F.G., Nunes L.R., Oliveira M.A., de Oliveira M.C., de Oliveira R.C., Palmieri D.A., Paris A., Peixoto B.R., Pereira G.A.G., Pereira H.A. Jr., Pesquero J.B., Quaggio R.B., Roberto P.G., Rodrigues V., de Rosa A.J.M., de Rosa V.E. Jr., de Sa R.G., Santelli R.V., Sawasaki H.E., da Silva A.C.R., da Silva A.M., da Silva F.R., Silva W.A. Jr., da Silveira J.F., Silvestri M.L.Z., Siqueira W.J., de Souza A.A., de Souza A.P., Terenzi M.F., Truffi D., Tsai S.M., Tsuhako M.H., Vallada H., Van Sluys M.A., Verjovski-Almeida S., Vettore A.L., Zago M.A., Zatz M., Meidanis J., Setubal J.C. Nature 406:151-159(2000) [PubMed: 10910347] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 9a5c.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE003849 Genomic DNA. Translation: AAF84319.1.
PIR	E82671.
RefSeq	NP_298799.1.
3D structure databases
SMR	Q9PD69. Positions 1-312.
ModBase	Search...
Genome annotation databases
GeneID	1127056.
GenomeReviews	Gene locus XF_1510 in contig AE003849_GR.
KEGG	xfa:XF1510.
NMPDR	fig|160492.1.peg.1506.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG677789.
OMA	ANTTWHL.
Enzyme and pathway databases
BioCyc	XFAS160492:XF1510-MONOMER.
BRENDA	3.4.11.5. 278708.
Family and domain databases
InterPro	IPR000073. AB_hydrolase_1. IPR005944. Pept_S33. IPR002410. Peptidase_S33. [Graphical view]
Pfam	PF00561. Abhydrolase_1. 1 hit. [Graphical view]
PIRSF	PIRSF006431. Pept_S33. 1 hit.
PRINTS	PR00793. PROAMNOPTASE.
TIGRFAMs	TIGR01249. pro_imino_pep_1. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PIP_XYLFA

Accession

Primary (citable) accession number: Q9PD69

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 11, 2001
Last sequence update:	October 1, 2000
Last modified:	February 9, 2010
This is version 66 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)