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Q9P9M3

- PYRF_HALSA

UniProt

Q9P9M3 - PYRF_HALSA

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Protein

Orotidine 5'-phosphate decarboxylase

Gene

pyrF

Organism
Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Orotidine 5'-phosphate = UMP + CO2.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei93 – 931Proton donorBy similarity

GO - Molecular functioni

  1. orotidine-5'-phosphate decarboxylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
  2. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Pyrimidine biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00070; UER00120.

Names & Taxonomyi

Protein namesi
Recommended name:
Orotidine 5'-phosphate decarboxylase (EC:4.1.1.23)
Alternative name(s):
OMP decarboxylase
Short name:
OMPDCase
Short name:
OMPdecase
Gene namesi
Name:pyrF
Synonyms:ura3
Ordered Locus Names:VNG_1673G
OrganismiHalobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium)
Taxonomic identifieri64091 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHalobacterium
ProteomesiUP000000554: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 267267Orotidine 5'-phosphate decarboxylasePRO_0000134637Add
BLAST

Proteomic databases

PaxDbiQ9P9M3.

Interactioni

Protein-protein interaction databases

STRINGi64091.VNG1673G.

Structurei

3D structure databases

ProteinModelPortaliQ9P9M3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0284.
InParanoidiQ9P9M3.
KOiK01591.
OMAiYAHGKNV.
PhylomeDBiQ9P9M3.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_01215. OMPdecase_type2.
InterProiIPR013785. Aldolase_TIM.
IPR018089. OMPdecase_AS.
IPR011995. OMPdecase_type-2.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTiSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
TIGRFAMsiTIGR02127. pyrF_sub2. 1 hit.
PROSITEiPS00156. OMPDECASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9P9M3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSFVEELGAR IEAADSVVSV GLDPDMERLP EDVQDAELPR WAFNRRIIDA
60 70 80 90 100
THEHAAVFKP NAAFYEDSDG WRALRETVAY AHGKGVPVLL DAKRADIGNT
110 120 130 140 150
ARQYAEILAH VDAITVNPYL GEDALQPFLT QDEAGVFVLC RTSNEGGMDF
160 170 180 190 200
QHLELAAYDR RLYEHVAERA AEWNAQYGDV GLVVGATAPD ELQAIRERVP
210 220 230 240 250
ELPFLVPGVG AQGGDAEAAV EYGLNDDGVG LVNSTRGVIF AGEHGSAWAA
260
AAGDAARTLR ERLNRHR
Length:267
Mass (Da):29,048
Last modified:June 24, 2002 - v3
Checksum:iB478E72A42572111
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF187997 Genomic DNA. Translation: AAF36353.1.
AE004437 Genomic DNA. Translation: AAG19923.1.
PIRiG84319.
RefSeqiNP_280443.1. NC_002607.1.
WP_010903220.1. NC_002607.1.

Genome annotation databases

EnsemblBacteriaiAAG19923; AAG19923; VNG_1673G.
GeneIDi1448223.
KEGGihal:VNG1673G.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF187997 Genomic DNA. Translation: AAF36353.1 .
AE004437 Genomic DNA. Translation: AAG19923.1 .
PIRi G84319.
RefSeqi NP_280443.1. NC_002607.1.
WP_010903220.1. NC_002607.1.

3D structure databases

ProteinModelPortali Q9P9M3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 64091.VNG1673G.

Proteomic databases

PaxDbi Q9P9M3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAG19923 ; AAG19923 ; VNG_1673G .
GeneIDi 1448223.
KEGGi hal:VNG1673G.

Phylogenomic databases

eggNOGi COG0284.
InParanoidi Q9P9M3.
KOi K01591.
OMAi YAHGKNV.
PhylomeDBi Q9P9M3.

Enzyme and pathway databases

UniPathwayi UPA00070 ; UER00120 .

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_01215. OMPdecase_type2.
InterProi IPR013785. Aldolase_TIM.
IPR018089. OMPdecase_AS.
IPR011995. OMPdecase_type-2.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view ]
Pfami PF00215. OMPdecase. 1 hit.
[Graphical view ]
SMARTi SM00934. OMPdecase. 1 hit.
[Graphical view ]
SUPFAMi SSF51366. SSF51366. 1 hit.
TIGRFAMsi TIGR02127. pyrF_sub2. 1 hit.
PROSITEi PS00156. OMPDECASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Homologous gene knockout in the archaeon Halobacterium salinarum with ura3 as a counterselectable marker."
    Peck R.F., DasSarma S., Krebs M.P.
    Mol. Microbiol. 35:667-676(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: MPK1.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700922 / JCM 11081 / NRC-1.

Entry informationi

Entry nameiPYRF_HALSA
AccessioniPrimary (citable) accession number: Q9P9M3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: June 24, 2002
Last modified: October 29, 2014
This is version 84 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3