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Protein

Orotidine 5'-phosphate decarboxylase

Gene

pyrF

Organism
Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Orotidine 5'-phosphate = UMP + CO2.

Pathwayi: UMP biosynthesis via de novo pathway

This protein is involved in step 2 of the subpathway that synthesizes UMP from orotate.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Orotate phosphoribosyltransferase (pyrE)
  2. Orotidine 5'-phosphate decarboxylase (pyrF)
This subpathway is part of the pathway UMP biosynthesis via de novo pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes UMP from orotate, the pathway UMP biosynthesis via de novo pathway and in Pyrimidine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei93Proton donorBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDecarboxylase, Lyase
Biological processPyrimidine biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00070; UER00120

Names & Taxonomyi

Protein namesi
Recommended name:
Orotidine 5'-phosphate decarboxylase (EC:4.1.1.23)
Alternative name(s):
OMP decarboxylase
Short name:
OMPDCase
Short name:
OMPdecase
Gene namesi
Name:pyrF
Synonyms:ura3
Ordered Locus Names:VNG_1673G
OrganismiHalobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium)
Taxonomic identifieri64091 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHalobacterium
Proteomesi
  • UP000000554 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001346371 – 267Orotidine 5'-phosphate decarboxylaseAdd BLAST267

Proteomic databases

PaxDbiQ9P9M3

Interactioni

Protein-protein interaction databases

STRINGi64091.VNG1673G

Structurei

3D structure databases

ProteinModelPortaliQ9P9M3
SMRiQ9P9M3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiarCOG00081 Archaea
COG0284 LUCA
InParanoidiQ9P9M3
KOiK01591
OMAiQSAFFER
OrthoDBiPOG093Z0B4G
PhylomeDBiQ9P9M3

Family and domain databases

Gene3Di3.20.20.70, 1 hit
HAMAPiMF_01215 OMPdecase_type2, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR018089 OMPdecase_AS
IPR011995 OMPdecase_type-2
IPR001754 OMPdeCOase_dom
IPR011060 RibuloseP-bd_barrel
PANTHERiPTHR43375 PTHR43375, 1 hit
PfamiView protein in Pfam
PF00215 OMPdecase, 1 hit
SMARTiView protein in SMART
SM00934 OMPdecase, 1 hit
SUPFAMiSSF51366 SSF51366, 1 hit
TIGRFAMsiTIGR02127 pyrF_sub2, 1 hit
PROSITEiView protein in PROSITE
PS00156 OMPDECASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q9P9M3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFVEELGAR IEAADSVVSV GLDPDMERLP EDVQDAELPR WAFNRRIIDA
60 70 80 90 100
THEHAAVFKP NAAFYEDSDG WRALRETVAY AHGKGVPVLL DAKRADIGNT
110 120 130 140 150
ARQYAEILAH VDAITVNPYL GEDALQPFLT QDEAGVFVLC RTSNEGGMDF
160 170 180 190 200
QHLELAAYDR RLYEHVAERA AEWNAQYGDV GLVVGATAPD ELQAIRERVP
210 220 230 240 250
ELPFLVPGVG AQGGDAEAAV EYGLNDDGVG LVNSTRGVIF AGEHGSAWAA
260
AAGDAARTLR ERLNRHR
Length:267
Mass (Da):29,048
Last modified:June 24, 2002 - v3
Checksum:iB478E72A42572111
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF187997 Genomic DNA Translation: AAF36353.1
AE004437 Genomic DNA Translation: AAG19923.1
PIRiG84319
RefSeqiWP_010903220.1, NC_002607.1

Genome annotation databases

EnsemblBacteriaiAAG19923; AAG19923; VNG_1673G
GeneIDi5953071
KEGGihal:VNG_1673G
PATRICifig|64091.14.peg.1274

Similar proteinsi

Entry informationi

Entry nameiPYRF_HALSA
AccessioniPrimary (citable) accession number: Q9P9M3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: June 24, 2002
Last modified: May 23, 2018
This is version 95 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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