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Q9P9L2

- MDH_HALVD

UniProt

Q9P9L2 - MDH_HALVD

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Protein

Malate dehydrogenase

Gene
mdh, HVO_3007
Organism
Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2) (Halobacterium volcanii)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate By similarity.UniRule annotation

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei34 – 341NAD By similarity
Binding sitei83 – 831Substrate By similarity
Binding sitei89 – 891Substrate By similarity
Binding sitei96 – 961NAD By similarity
Binding sitei121 – 1211Substrate By similarity
Binding sitei152 – 1521Substrate By similarity
Active sitei176 – 1761Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi8 – 147NAD By similarity
Nucleotide bindingi119 – 1213NAD By similarity

GO - Molecular functioni

  1. L-malate dehydrogenase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. cellular carbohydrate metabolic process Source: InterPro
  2. malate metabolic process Source: InterPro
  3. tricarboxylic acid cycle Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Tricarboxylic acid cycle

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciHVOL309800:GCOK-3013-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenase (EC:1.1.1.37)
Gene namesi
Name:mdh
Ordered Locus Names:HVO_3007
OrganismiHaloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2) (Halobacterium volcanii)
Taxonomic identifieri309800 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHaloferax
ProteomesiUP000008243: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 304304Malate dehydrogenaseUniRule annotationPRO_0000113483Add
BLAST

Structurei

Secondary structure

1
304
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi3 – 86
Helixi12 – 2413
Beta strandi28 – 336
Helixi36 – 383
Helixi39 – 5315
Turni54 – 563
Beta strandi60 – 634
Helixi66 – 694
Beta strandi73 – 775
Helixi89 – 10820
Beta strandi115 – 1184
Helixi123 – 13210
Beta strandi134 – 1363
Helixi138 – 1403
Beta strandi141 – 1433
Helixi146 – 16116
Helixi165 – 1673
Beta strandi172 – 1743
Beta strandi180 – 1823
Helixi184 – 1863
Helixi198 – 21619
Turni217 – 2193
Helixi224 – 23815
Beta strandi244 – 25310
Helixi254 – 2563
Beta strandi258 – 26912
Beta strandi272 – 2765
Helixi283 – 30321

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4BGUX-ray1.49A/B/C/D2-304[»]
ProteinModelPortaliQ9P9L2.
SMRiQ9P9L2. Positions 2-304.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000213793.
KOiK00024.
OMAiLMSAGMP.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPiMF_00487. Malate_dehydrog_3.
InterProiIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR011275. Malate_DH_type3.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11540. PTHR11540. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSiPR00086. LLDHDRGNASE.
SUPFAMiSSF56327. SSF56327. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9P9L2-1 [UniParc]FASTAAdd to Basket

« Hide

MTKVSVIGAA GTVGAAAGYN LALRDVCDEL VFVDIPKMED KTVGQAADTN    50
HGIAYDSNTV VTQGGYEDTA GSDVVVITAG IPRQPGQTRI DLAGDNAPIM 100
DDIGSSLAEY NDDFVSITTS NPVDLLNRHL YETGDRDRHK VIGFGGRLDS 150
ARFRYVLSQR FDVPVKNVDA TILGEHGDAQ VPVFSKVRVD GNDPAFSADE 200
KEEILGDLQE SAMDVIERKG ATQWGPATGV AHMVEAVLHD TGEVLPGSLV 250
LDGEFGYEDT AFGVPVKLGS NGIEEVVEWD LDDYEADLMD DAAEKLRDQY 300
DEIA 304
Length:304
Mass (Da):32,654
Last modified:September 21, 2011 - v2
Checksum:i7AD72EDC9C137268
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti17 – 171A → G in AAF43044. 1 Publication
Sequence conflicti285 – 2851Missing in AAF43044. 1 Publication
Sequence conflicti290 – 2901D → N in AAF43044. 1 Publication
Sequence conflicti297 – 2971R → L in AAF43044. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF236112 Genomic DNA. Translation: AAF43044.1.
DQ851095 Genomic DNA. Translation: ABH10498.1.
CP001956 Genomic DNA. Translation: ADE04975.1.
RefSeqiYP_003537012.1. NC_013967.1.

Genome annotation databases

EnsemblBacteriaiADE04975; ADE04975; HVO_3007.
GeneIDi8925993.
KEGGihvo:HVO_3007.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF236112 Genomic DNA. Translation: AAF43044.1 .
DQ851095 Genomic DNA. Translation: ABH10498.1 .
CP001956 Genomic DNA. Translation: ADE04975.1 .
RefSeqi YP_003537012.1. NC_013967.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4BGU X-ray 1.49 A/B/C/D 2-304 [» ]
ProteinModelPortali Q9P9L2.
SMRi Q9P9L2. Positions 2-304.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADE04975 ; ADE04975 ; HVO_3007 .
GeneIDi 8925993.
KEGGi hvo:HVO_3007.

Phylogenomic databases

HOGENOMi HOG000213793.
KOi K00024.
OMAi LMSAGMP.

Enzyme and pathway databases

BioCyci HVOL309800:GCOK-3013-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPi MF_00487. Malate_dehydrog_3.
InterProi IPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR011275. Malate_DH_type3.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR11540. PTHR11540. 1 hit.
Pfami PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000102. Lac_mal_DH. 1 hit.
PRINTSi PR00086. LLDHDRGNASE.
SUPFAMi SSF56327. SSF56327. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The gene coding for Haloferax volcanii malate dehydrogenase."
    Mevarech M.
    Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Expression of halophilic malate dehydrogenase of Haloferax volcanii."
    Tetsch L., Galinski E.A.
    Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2.

Entry informationi

Entry nameiMDH_HALVD
AccessioniPrimary (citable) accession number: Q9P9L2
Secondary accession number(s): D4GYB6, Q0MSE3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: September 21, 2011
Last modified: July 9, 2014
This is version 75 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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