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Q9P9L2

- MDH_HALVD

UniProt

Q9P9L2 - MDH_HALVD

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Protein

Malate dehydrogenase

Gene

mdh

Organism
Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2) (Halobacterium volcanii)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate.UniRule annotation

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei34 – 341NADUniRule annotation
Binding sitei83 – 831SubstrateUniRule annotation
Binding sitei89 – 891SubstrateUniRule annotation
Binding sitei96 – 961NADUniRule annotation
Binding sitei121 – 1211SubstrateUniRule annotation
Binding sitei152 – 1521SubstrateUniRule annotation
Active sitei176 – 1761Proton acceptorUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi8 – 147NADUniRule annotation
Nucleotide bindingi119 – 1213NADUniRule annotation

GO - Molecular functioni

  1. L-malate dehydrogenase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. cellular carbohydrate metabolic process Source: InterPro
  2. malate metabolic process Source: InterPro
  3. tricarboxylic acid cycle Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Tricarboxylic acid cycle

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciHVOL309800:GCOK-3013-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenaseUniRule annotation (EC:1.1.1.37UniRule annotation)
Gene namesi
Name:mdhUniRule annotation
Ordered Locus Names:HVO_3007
OrganismiHaloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2) (Halobacterium volcanii)
Taxonomic identifieri309800 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHaloferax
ProteomesiUP000008243: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 304304Malate dehydrogenasePRO_0000113483Add
BLAST

Structurei

Secondary structure

1
304
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi3 – 86Combined sources
Helixi12 – 2413Combined sources
Beta strandi28 – 336Combined sources
Helixi36 – 383Combined sources
Helixi39 – 5315Combined sources
Turni54 – 563Combined sources
Beta strandi60 – 634Combined sources
Helixi66 – 694Combined sources
Beta strandi73 – 775Combined sources
Helixi89 – 10820Combined sources
Beta strandi115 – 1184Combined sources
Helixi123 – 13210Combined sources
Beta strandi134 – 1363Combined sources
Helixi138 – 1403Combined sources
Beta strandi141 – 1433Combined sources
Helixi146 – 16116Combined sources
Helixi165 – 1673Combined sources
Beta strandi172 – 1743Combined sources
Beta strandi180 – 1823Combined sources
Helixi184 – 1863Combined sources
Helixi198 – 21619Combined sources
Turni217 – 2193Combined sources
Helixi224 – 23815Combined sources
Beta strandi244 – 25310Combined sources
Helixi254 – 2563Combined sources
Beta strandi258 – 26912Combined sources
Beta strandi272 – 2765Combined sources
Helixi283 – 30321Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4BGUX-ray1.49A/B/C/D2-304[»]
ProteinModelPortaliQ9P9L2.
SMRiQ9P9L2. Positions 2-304.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. MDH type 3 family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000213793.
KOiK00024.
OMAiLMSAGMP.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPiMF_00487. Malate_dehydrog_3.
InterProiIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR011275. Malate_DH_type3.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11540. PTHR11540. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSiPR00086. LLDHDRGNASE.
SUPFAMiSSF56327. SSF56327. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9P9L2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTKVSVIGAA GTVGAAAGYN LALRDVCDEL VFVDIPKMED KTVGQAADTN
60 70 80 90 100
HGIAYDSNTV VTQGGYEDTA GSDVVVITAG IPRQPGQTRI DLAGDNAPIM
110 120 130 140 150
DDIGSSLAEY NDDFVSITTS NPVDLLNRHL YETGDRDRHK VIGFGGRLDS
160 170 180 190 200
ARFRYVLSQR FDVPVKNVDA TILGEHGDAQ VPVFSKVRVD GNDPAFSADE
210 220 230 240 250
KEEILGDLQE SAMDVIERKG ATQWGPATGV AHMVEAVLHD TGEVLPGSLV
260 270 280 290 300
LDGEFGYEDT AFGVPVKLGS NGIEEVVEWD LDDYEADLMD DAAEKLRDQY

DEIA
Length:304
Mass (Da):32,654
Last modified:September 21, 2011 - v2
Checksum:i7AD72EDC9C137268
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti17 – 171A → G in AAF43044. 1 PublicationCurated
Sequence conflicti285 – 2851Missing in AAF43044. 1 PublicationCurated
Sequence conflicti290 – 2901D → N in AAF43044. 1 PublicationCurated
Sequence conflicti297 – 2971R → L in AAF43044. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF236112 Genomic DNA. Translation: AAF43044.1.
DQ851095 Genomic DNA. Translation: ABH10498.1.
CP001956 Genomic DNA. Translation: ADE04975.1.
RefSeqiYP_003537012.1. NC_013967.1.

Genome annotation databases

EnsemblBacteriaiADE04975; ADE04975; HVO_3007.
GeneIDi8925993.
KEGGihvo:HVO_3007.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF236112 Genomic DNA. Translation: AAF43044.1 .
DQ851095 Genomic DNA. Translation: ABH10498.1 .
CP001956 Genomic DNA. Translation: ADE04975.1 .
RefSeqi YP_003537012.1. NC_013967.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4BGU X-ray 1.49 A/B/C/D 2-304 [» ]
ProteinModelPortali Q9P9L2.
SMRi Q9P9L2. Positions 2-304.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADE04975 ; ADE04975 ; HVO_3007 .
GeneIDi 8925993.
KEGGi hvo:HVO_3007.

Phylogenomic databases

HOGENOMi HOG000213793.
KOi K00024.
OMAi LMSAGMP.

Enzyme and pathway databases

BioCyci HVOL309800:GCOK-3013-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPi MF_00487. Malate_dehydrog_3.
InterProi IPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR011275. Malate_DH_type3.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR11540. PTHR11540. 1 hit.
Pfami PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000102. Lac_mal_DH. 1 hit.
PRINTSi PR00086. LLDHDRGNASE.
SUPFAMi SSF56327. SSF56327. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The gene coding for Haloferax volcanii malate dehydrogenase."
    Mevarech M.
    Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Expression of halophilic malate dehydrogenase of Haloferax volcanii."
    Tetsch L., Galinski E.A.
    Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2.

Entry informationi

Entry nameiMDH_HALVD
AccessioniPrimary (citable) accession number: Q9P9L2
Secondary accession number(s): D4GYB6, Q0MSE3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: September 21, 2011
Last modified: October 29, 2014
This is version 77 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3